排序方式: 共有7条查询结果,搜索用时 15 毫秒
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Kumari Maddineni Aruna Rao Chunduri Venkata Triloknadh Settypalli Harikrishna Nallapaneni Venkataramaiah Chintha Rajendra Wudayagiri Trinath Daggupati Suneetha Yeguvapalli 《Research on Chemical Intermediates》2018,44(3):1989-2008
Research on Chemical Intermediates - In an attempt to find potential neuroprotective agents, a series of novel 3-(1-((1-(substituted phenyl)-1H-1,2,3-triazol-4-yl) methoxyimino)... 相似文献
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Shaik Mahaboob Basha Mavallur Varalakshmi Shaik Thaslim Basha Chintha Venkataramaiah Suban Syed Shafi Chamarthi Naga Raju Wudayagiri Rajendra 《中国化学会会志》2019,66(12):1700-1707
A series of new imidazole‐substituted pyridine‐2‐amine and benzo‐substituted imidazol‐2‐amine 3 – 12 were synthesized by treating various amines 1(a – d) with alkyl/aryl isothiocyanate 2(a‐c) at 60–90°C in isopropyl alcohol without using any catalyst with high yields. The structures of all the newly synthesized compounds were characterized using IR, NMR (1H, 13C), mass, and elemental analyses. All the newly synthesized compounds were screened for their in vitro antioxidant and antimicrobial activities to understand their biological potency. All the title compounds exhibited good antioxidant and antimicrobial activities in vitro when compared to the standard drugs. 相似文献
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Rajendra Wudayagiri Bora Inceoglu Rafael Herrmann Maher Derbel Prabhakara V Choudary Bruce D Hammock 《BMC biochemistry》2001,2(1):16-8
Background
Scorpion venom contains insect and mammal selective toxins. We investigated the venom of the South Indian red scorpion, Mesobuthus tamulus for the purpose of identifying potent insecticidal peptide toxins.Results
A lepidopteran-selective toxin (Buthus tamulus insect toxin; ButaIT) has been isolated from this venom. The primary structure analysis reveals that it is a single polypeptide composed of 37 amino acids cross-linked by four disulfide bridges with high sequence homology to other short toxins such as Peptide I, neurotoxin P2, Lqh-8/6, chlorotoxin, insectotoxin I5A, insect toxin 15 and insectotoxin I1. Three dimensional modeling using Swiss automated protein modeling server reveals that this toxin contains a short α-helix and three antiparallel β-strands, similar to other short scorpion toxins. This toxin is selectively active on Heliothis virescens causing flaccid paralysis but was non-toxic to blowfly larvae and mice.Conclusion
This is the first report of a Heliothine selective peptide toxin. Identification of diverse insect selective toxins offer advantages in employing these peptides selectively for pest control. 相似文献5.
Bogiri Sujatha Venkataramaiah Chintha Rajendra Wudayagiri 《Phosphorus, sulfur, and silicon and the related elements》2020,195(7):586-591
AbstractA sequence of substituted phosphonates containing the thiazolidinedione moiety was synthesized with good yields. The structures of all the synthesized compounds were confirmed by NMR (31P, 1H and 13C) and IR spectroscopy, mass spectrometry and C, H, N elemental analyses. In silico molecular docking study was also carried out to evaluate their interaction and binding modes on ligands against human PPAR γ protein for their anti-diabetic activity. From the docking results, it was determined that the compounds (Z)-dimethyl 5-(3-nitrobenzylidene)?2,4-dioxothiazolidin-3-ylphosphonate (7a), (Z)-dimethyl 5-(3-chloro-4-fluorobenzylidene)?2,4-dioxothiazolidin-3-ylphosphonate (7f), (Z)-dimethyl 5-(2,4-dichlorobenzylidene)?2,4-dioxothiazolidin-3-ylphosphonate (7e) and (Z)-dimethyl 5-((5-methoxypyridin-2-yl)methylene)?2,4-dioxothiazolidin-3-ylphosphonate (7j) have shown better binding energies (?7.8, ?7.6, ?7.5 and ?7.6 Kcal/mol) with the target gene, PPAR γ than the reference drug, Rosiglitazone (?7.4 Kcal/mol). In vitro anti-diabetic activity of the title compounds was also screened by standard α-amylase inhibition assay. Some of the tested compounds proved to possess promising activity when compared with the reference drug. 相似文献
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Chandrasekhar Mandala Prasad Gandavaram Syam Venkataramaiah Chintha Naga Raju Chamarthi Seshaiah Kalluru Rajendra Wudayagiri 《Molecular diversity》2019,23(3):723-738
Molecular Diversity - A series of new urea/thiourea derivatives 3a–j were synthesized by simple addition reaction of functionalized phenyl isocyanates/isothiocyanates 2a–j with... 相似文献
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Vijay Kumar Reddy Avula Venkata Ramaiah Chintha Swetha Vallela Jaya Shree Anireddy Naga Raju Chamarthi Rajendra Wudayagiri 《Journal of heterocyclic chemistry》2019,56(1):209-217
An efficient method has been developed for the synthesis of N‐alkylated 2′‐oxo‐3‐phenylspiro[cyclopropane‐1,3′‐indoline]‐2,2‐dicarbonitrile from 3‐chloroindolin‐2‐one and 2‐benzylidenemalononitrile by using triethylamine as a base at room temperature and obtained the products in moderate to good yields. In extension, the scope of the reaction has been investigated by stepwise and one‐pot methods. Furthermore, in silico antibacterial activity was carried out in order to understand possible binding modes of novel derivatives with the active site of DNA gyrase A enzyme, and the results were well complemented. Additionally, absorption, distribution, metabolism, and excretion properties of compounds have shown drug likeness with good oral absorption and moderate blood–brain barrier permeability. 相似文献
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