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1.
The enantioselective synthesis of the potent, selective, cytotoxic, annonaceous acetogenin, (+)-gigantecin, has been completed. An asymmetric glycolate aldol serves to establish the stereocenters at C13,14 and at C21,22. A Carreira asymmetric acetylide addition is used to establish the C17 stereocenter. 相似文献
2.
The first total synthesis of marine bioactive cyclic heptapeptide Leucamide A has been accomplished, including a simple method for construction of the 4,2-bisheterocycle tandem pair substructure that employs a DAST-mediated cyclization of beta-hydroxy amide and final HBTU-promoted ring closing. 相似文献
3.
Weiguo Wang Minkang Feng Xiaomeng Li Feiyu Chen Zhihao Zhang Wenlong Yang Chen Shao Liming Tao Yang Zhang 《Molecules (Basel, Switzerland)》2022,27(15)
Actinomycetes play a vital role as one of the most important natural resources for both pharmaceutical and agricultural applications. The actinomycete strain SPRI-371, isolated from soil collected in Jiangsu province, China, was classified as Streptomyces aureus based on its morphological, physiological, biochemical and molecular biological characteristics. Its bacterial activity metabolites were identified as aureonuclemycin (ANM), belonging to adenosine derivatives with the molecular formula C16H19N5O9 for ANM A and C10H13N5O3 for ANM B. Simultaneously, the industrial fermentation process of a mutated S. aureus strain SPRI-371 was optimized in a 20 m3 fermentation tank, featuring a rotation speed of 170 rpm, a pressure of 0.05 MPa, an inoculum age of 36–40 h and a dissolved oxygen level maintained at 1–30% within 40–80 h and at >60% in the later period, resulting in an ANM yield of >3700 mg/L. In the industrial separation of fermentation broth, the sulfuric acid solution was selected to adjust pH and 4# resin was used for adsorption. Then, it was resolved with 20% ethanol solution and concentrated in a vacuum (60–65 °C), with excellent results. Antibacterial experiments showed that ANM was less active or inactive against Xanthomonas oryzae pv. oryzae, Xanthomonas citri subsp. citri and Xanthomonas oryzae pv. oryzicola and most bacteria, yeast and fungi in vitro. However, in vivo experiments showed that ANM exhibited extremely significant protective and therapeutic activity against diseases caused by X. oryzae pv. oryzae and X. oryzae pv. oryzicola in rice and X. citri in oranges and lemons. In field trials, ANM A 150 gai/ha + ANM B 75 gai/ha exhibited excellent therapeutic activity against rice bacterial leaf blight, citrus canker and rice bacterial leaf streak. Furthermore, as the dosage and production cost of ANM are lower than those of commercial drugs, it has good application prospects. 相似文献
4.
5.
The internal modes of incoherent vector solitons (IVSs) in
photovoltaic photorefractive materials are investigated in the
framework of coupled nonlinear Schr\"{o}dinger equations. It is found
that there is a pair of internal modes corresponding to a
bright--bright IVS. The propagation dynamics of the bright-bright IVS
perturbed by the internal modes is simulated by numerical method. 相似文献
6.
A method for improving the quality of all-optical switching is presented. Pumping poly(methyl methacrylate) (PMMA) films doped with azobenzene chromophore Disperse Red 1 (DR1) with two beams (a linearly and a circularly polarized), all-optical switching effects with very low background and high stability are demonstrated. High frequency switching, which is hard to be realized under pump of a single beam, is obtained. The circularly polarized pump beam can erase the photoinduced birefringence and quicken the relaxation process, thus lowering the background and improving the stability and the extinction ratio of the switching signal. PACS 42.70.Jk; 42.25.Lc; 82.30.Qt; 78.20.Fm; 77.80.Fm 相似文献
7.
Shou Xian She 《Optical and Quantum Electronics》1991,23(8):1045-1054
We present a simple and accurate method for characteristic analysis of metal-clad dielectric waveguides and absorptive waveguides. The real partN of the complex modal indexN=N + iN is obtained by solving the corresponding real eigenvalue equation, and the imaginary partN is given by (n/), where= + i is the complex dielectric constant of the absorptive layer, and N/ is obtained by numerical differentiation. The method is straightforward, and the cumbersome solution of complex transcendental equations is completely eliminated. Results for simple structures are in good agreement with those obtained by exact analysis. 相似文献
8.
本文提出了用准直孔结合调节束流导引磁场获得较好品质强流电子束的方法,运用该方法在1.5MeV直线感应加速器(LIA)进行了试验,结果准直束流前后沿明显减小,束亮度提高几倍;同时,用此方法测出了束密度及束亮度的径向分布. 相似文献
9.
Rolling bearings act as key parts in many items of mechanical equipment and any abnormality will affect the normal operation of the entire apparatus. To diagnose the faults of rolling bearings effectively, a novel fault identification method is proposed by merging variational mode decomposition (VMD), average refined composite multiscale dispersion entropy (ARCMDE) and support vector machine (SVM) optimized by multistrategy enhanced swarm optimization in this paper. Firstly, the vibration signals are decomposed into different series of intrinsic mode functions (IMFs) based on VMD with the center frequency observation method. Subsequently, the proposed ARCMDE, fusing the superiorities of DE and average refined composite multiscale procedure, is employed to enhance the ability of the multiscale fault-feature extraction from the IMFs. Afterwards, grey wolf optimization (GWO), enhanced by multistrategy including levy flight, cosine factor and polynomial mutation strategies (LCPGWO), is proposed to optimize the penalty factor C and kernel parameter g of SVM. Then, the optimized SVM model is trained to identify the fault type of samples based on features extracted by ARCMDE. Finally, the application experiment and contrastive analysis verify the effectiveness of the proposed VMD-ARCMDE-LCPGWO-SVM method. 相似文献
10.
We demonstrate a harmonically pumped femtosecond optical parametric oscillator(OPO)laser using a frequency-doubled mode-locked Yb:KGW laser at a repetition rate of 75.5 MHz as the pump laser.Based on a bismuth borate nonlinear crystal,repetition rates up to 1.13 GHz are realized,which is 15 times that of the pump laser.The signal wavelength is tunable from 700 nm to 887 nm.The maximum power of the signal is 207 m W at the central wavelength of 750 nm and the shortest pulse duration is 117 fs at 780 nm.The beam quality(M^2 factor)in the horizontal and vertical directions of the output beam are 1.077 and 1.141,respectively. 相似文献