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排序方式: 共有139条查询结果,搜索用时 31 毫秒
1.
Udo Feldkamp Ron Wacker Hendrik Schroeder Wolfgang Banzhaf Christof M Niemeyer 《Chemphyschem》2004,5(3):367-372
We report on the microarray-based in vitro evaluation of two libraries of DNA oligonucleotide sequences, designed in silico for applications in supramolecular self-assembly, such as DNA computing and DNA-based nanosciences. In this first study which is devoted to the comparison of sequence motif properties theoretically predicted with their performance in real-life, the DNA-directed immobilization (DDI) of proteins was used as an example of DNA-based self-assembly. Since DDI technologies, DNA computing, and DNA nanoconstruction essentially depend on similar prereguisites, in particular, large and uniform hybridization efficiencies combined with low nonspecific cross-reactivity between individual sequences, we anticipate that the microarray approach demonstrated here will enable rapid evaluation of other DNA sequence libraries. 相似文献
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Vickers microhardness measurements were performed on single crystals of compounds Tl3BX4 (B = V, Nb, Ta; X = S, Se). The anisotropy of the hardness on the (111)-plane was beyond the standard deviation. Besides the load-dependent Vickers hardness HV, the corrected, load-independent hardness HVc was determined. Tl3VS4 showed the highest value of hardness (HV = 66 kp/mm2 at 15 p load), the othe compounds differ only slightly in hardness. 相似文献
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Atom interferometry is a rapidly advancing field and this Letter proposes an experiment based on existing technology that can search for new short distance forces. With current technology it is possible to improve the sensitivity by up to a factor of 102 and near-future advances may be able to rewrite the limits for forces with ranges from 1 mm to 100 m. 相似文献
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G. Alexander L. Criegee H.C. Dehne K. Derikum R. Devenish G. Flügge G. Franke Ch. Gerke E. Hackmack P. Harms G. Horlitz Th. Kahl G. Knies E. Lehmann R. Schmitz U. Timm P. Waloschek K. Wacker 《Physics letters. [Part B]》1978,78(1):162-166
The decay of the heavy lepton τ into πv has been established using the magnetic detector PLUTO. The branching ratio is determined to be BR(τ→πv)=(9.0 ± 2.9)% with an additional systematic uncertainty of 2.5%. This value is in good agreement with the theoretical prediction. 相似文献
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W. Frick W. Krämer A. Mehlmann Hj. Wacker 《Mathematical Methods of Operations Research》1986,30(4):B121-B123
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Wacker SA Kashyap S Li X Kapoor TM 《Journal of the American Chemical Society》2011,133(32):12386-12389
It is difficult to determine a chemical inhibitor's binding site in multiprotein mixtures, particularly when high-resolution structural studies are not straightforward. Building upon previous research involving photo-cross-linking and the use of mixtures of stable isotopes, we report a method, Stable Isotope Labeled Inhibitors for Cross-linking (SILIC), for mapping a small molecule inhibitor's binding site in its target protein. In SILIC, structure-activity relationship data is used to design inhibitor analogues that incorporate a photo-cross-linking group along with either natural or 'heavy' stable isotopes. An equimolar mixture of these inhibitor analogues is cross-linked to the target protein to yield a robust signature for identifying inhibitor-modified peptide fragments in complex mass spectrometry data. As a proof of concept, we applied this approach to an ATP-competitive inhibitor of kinesin-5, a widely conserved motor protein required for cell division and an anticancer drug target. This analysis, along with mutagenesis studies, suggests that the inhibitor binds at an allosteric site in the motor protein. 相似文献