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Machado Poliana A. L. Cavalcanti Marcello H. S. Silva Fábio A. B. de Almeida Eduardo T. Cardoso Marcus V. C. Mesquita Anderson F. Lemes Nelson H. T. Virtuoso Luciano S. 《Journal of solution chemistry》2022,51(3):320-344
Journal of Solution Chemistry - Liquid–liquid equilibrium (LLE) data and phase diagrams for new aqueous two-phase systems (ATPSs) containing 1-butyl-3-methylimidazolium chloride... 相似文献
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Paulo Emilio Feuser Amanda Virtuoso Jacques Juan Marcelo Carpio Arévalo Maria Eliane Merlin Rocha Maria Claudia dos Santos-Silva Claudia Sayer Pedro H. Hermes de Araújo 《Journal of nanoparticle research》2016,18(4):104
The encapsulation of superparamagnetic nanoparticles (MNPs) in polymeric nanoparticles (NPs) with modified surfaces can improve targeted delivery and induce cell death by hyperthermia. The goals of this study were to synthesize and characterize surface modified superparamagnetic poly(methyl methacrylate) with folic acid (FA) prepared by miniemulsion polymerization (MNPsPMMA-FA) and to evaluate their in vitro cytotoxicity and cellular uptake in non-tumor cells, murine fibroblast (L929) cells and tumor cells that overexpressed folate receptor (FR) β, and chronic myeloid leukemia cells in blast crisis (K562). Lastly, hemolysis assays were performed on human red blood cells. MNPsPMMA-FA presented an average mean diameter of 135 nm and a saturation magnetization (Ms) value of 37 emu/g of iron oxide, as well as superparamagnetic behavior. The MNPsPMMA-FA did not present cytotoxicity in L929 and K562 cells. Cellular uptake assays showed a higher uptake of MNPsPMMA-FA than MNPsPMMA in K562 cells when incubated at 37 °C. On the other hand, MNPsPMMA-FA showed a low uptake when endocytosis mechanisms were blocked at low temperature (4 °C), suggesting that the MNPsPMMA-FA uptake was mediated by endocytosis. High concentrations of MNPsPMMA-FA showed hemocompatibility when incubated for 24 h in human red blood cells. Therefore, our results suggest that these carrier systems can be an excellent alternative in targeted drug delivery via FR. 相似文献
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Victor Hugo Catricala Fernandes Natalie de Barros Viera Luiza Beatriz Lima Zanini Aline de Fátima Silva Paula Pio de Oliveira Salem Marisi Gomes Soares Karen de Jesus Nicácio Ana Claudia Chagas de Paula Luciano Sindra Virtuoso Tiago Branquinho Oliveira Eliane de Oliveira Silva Danielle Ferreira Dias Daniela Aparecida Chagas-Paula 《Photochemistry and photobiology》2020,96(1):14-20
There is some evidence in the literature of the photocyclization reaction of Tagitinin C ( 1 ) to Tagitinin F ( 2 ). Compound 2 has high pharmacological potential, but it is not easy to obtain, while compound 1 is easily obtained from a widespread plant, Tithonia diversifolia. Among different reaction conditions monitored, one was found that allowed the cyclization of 1 into 2 in <15 min in a photo-dependent reaction. Scaling-up the photocyclization of the pure compound 1 into 2 demonstrated 100% yield, and the isolation of 2 from a UV-irradiated extract was eight-fold higher than the quantity isolated from the non-UV-irradiated extract. We were also able to better understand the process of photoconversion and determine methods to isolate and quantify these compounds, which are known for their important antitumoral activities among other important pharmacological properties. 相似文献
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