全文获取类型
收费全文 | 52篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
化学 | 25篇 |
晶体学 | 2篇 |
数学 | 2篇 |
物理学 | 24篇 |
出版年
2021年 | 1篇 |
2020年 | 1篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 1篇 |
2011年 | 2篇 |
2009年 | 1篇 |
2008年 | 2篇 |
2007年 | 3篇 |
2005年 | 1篇 |
2004年 | 2篇 |
2002年 | 2篇 |
1999年 | 1篇 |
1998年 | 3篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1969年 | 2篇 |
1963年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1957年 | 1篇 |
1935年 | 2篇 |
排序方式: 共有53条查询结果,搜索用时 31 毫秒
1.
VI. Sedláček 《Czechoslovak Journal of Physics》1988,38(5):465-469
The formation of slip bands is the main mechanism of cyclic deformation in pure Al. Their density, orientation and heights in polycrystalline Al were investigated during cycling. Types, sizes and densities of precipitates are responsible for the mode of cyclic deformation in AlCu4 pure alloy. In technical Al alloys intermetallic phases have detrimental effects on deformation homogeneity and largely govern the fatigue mechanism of the material and especially microcrack initiation. 相似文献
2.
3.
Mordvintsev DY Polyak YL Levtsova OV Tourleigh YV Kasheverov IE Shaitan KV Utkin YN Tsetlin VI 《Computational Biology and Chemistry》2005,29(6):398-411
Short-chain alpha-neurotoxins from snakes are highly selective antagonists of the muscle-type nicotinic acetylcholine receptors (nAChR). Although their spatial structures are known and abundant information on topology of binding to nAChR is obtained by labeling and mutagenesis studies, the accurate structure of the complex is not yet known. Here, we present a model for a short alpha-neurotoxin, neurotoxin II from Naja oxiana (NTII), bound to Torpedo californica nAChR. It was built by comparative modeling, docking and molecular dynamics using 1H NMR structure of NTII, cross-linking and mutagenesis data, cryoelectron microscopy structure of Torpedo marmorata nAChR [Unwin, N., 2005. Refined structure of the nicotinic acetylcholine receptor at 4A resolution. J. Mol. Biol. 346, 967-989] and X-ray structures of acetylcholine-binding protein (AChBP) with agonists [Celie, P.H., van Rossum-Fikkert, S.E., van Dijk, W.J., Brejc, K., Smit, A.B., Sixma, T.K., 2004. Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron 41 (6), 907-914] and antagonists: alpha-cobratoxin, a long-chain alpha-neurotoxin [Bourne, Y., Talley, T.T., Hansen, S.B., Taylor, P., Marchot, P., 2005. Crystal structure of Cbtx-AChBP complex reveals essential interactions between snake alpha-neurotoxins and nicotinic receptors. EMBO J. 24 (8), 1512-1522] and alpha-conotoxin [Celie, P.H., Kasheverov, I.E., Mordvintsev, D.Y., Hogg, R.C., van Nierop, P., van Elk, R., van Rossum-Fikkert, S.E., Zhmak, M.N., Bertrand, D., Tsetlin, V., Sixma, T.K., Smit, A.B., 2005. Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant. Nat. Struct. Mol. Biol. 12 (7), 582-588]. In complex with the receptor, NTII was located at about 30 A from the membrane surface, the tip of its loop II plunges into the ligand-binding pocket between the alpha/gamma or alpha/delta nAChR subunits, while the loops I and III contact nAChR by their tips only in a 'surface-touch' manner. The toxin structure undergoes some changes during the final complex formation (for 1.45 rmsd in 15-25 ps according to AMBER'99 molecular dynamics simulation), which correlates with NMR data. The data on the mobility and accessibility of spin- and fluorescence labels in free and bound NTII were used in MD simulations. The binding process is dependent on spontaneous outward movement of the C-loop earlier found in the AChBP complexes with alpha-cobratoxin and alpha-conotoxin. Among common features in binding of short- and long alpha-neurotoxins is the rearrangement of aromatic residues in the binding pocket not observed for alpha-conotoxin binding. Being in general very similar, the binding modes of short- and long alpha-neurotoxins differ in the ways of loop II entry into nAChR. 相似文献
4.
Denis Kudryavtsev Anastasia Isaeva Daria Barkova Ekaterina Spirova Renata Mukhutdinova Igor Kasheverov Victor Tsetlin 《Molecules (Basel, Switzerland)》2021,26(5)
Slow-channel congenital myasthenic syndromes (SCCMSs) are rare genetic diseases caused by mutations in muscle nicotinic acetylcholine receptor (nAChR) subunits. Most of the known SCCMS-associated mutations localize at the transmembrane region near the ion pore. Only two SCCMS point mutations are at the extracellular domains near the acetylcholine binding site, α1(G153S) being one of them. In this work, a combination of molecular dynamics, targeted mutagenesis, fluorescent Ca2+ imaging and patch-clamp electrophysiology has been applied to G153S mutant muscle nAChR to investigate the role of hydrogen bonds formed by Ser 153 with C-loop residues near the acetylcholine-binding site. Introduction of L199T mutation to the C-loop in the vicinity of Ser 153 changed hydrogen bonds distribution, decreased acetylcholine potency (EC50 2607 vs. 146 nM) of the double mutant and decay kinetics of acetylcholine-evoked cytoplasmic Ca2+ rise (τ 14.2 ± 0.3 vs. 34.0 ± 0.4 s). These results shed light on molecular mechanisms of nAChR activation-desensitization and on the involvement of such mechanisms in channelopathy genesis. 相似文献
5.
Data from the R-16 radiation dosimeter mounted to the outside of the Mir space station are analyzed to determine the radiation environment and absorbed radiation dose inside Mir during the 22nd solar cycle. The outcome of the analysis demonstrated that data could be collected over a long period, dynamics of the daily mean absorbed doses correlated well with parameters of solar activity, seasonal variations of absorbed doses during the solar cycle were clearly observed, during periods of unfavorable conditions the absorbed dose rate within the living modules can reach up to 30 mrad/min for more than 10 minutes, and overall, the radiation environment inside the space station was low. 相似文献
6.
L. Rosenthaler P. Krumholz J. Vasquez Sanchez F. Feigl A. S. Komarowsky N. S. Poluektoff J. V. Dubský J. Trtilek A. Oká G. Hellsing K. Heumann F. Emich Olga S. Fedorova Georges Glomaud J. Trtílek VI. Stanék T. Nemes Carl Urbach R. Baril und J. H. Yoe 《Fresenius' Journal of Analytical Chemistry》1935,102(7-8):280-289
Ohne Zusammenfassung 相似文献
7.
A. A. Belyanin V. V. Kocharovsky VI. V. Kocharovsky 《Radiophysics and Quantum Electronics》1996,41(1):22-27
It is believed that the detection of gamma-ray bursts from evaporating primordial black holes is highly improbable in the
near future since the expected photon flux, consisting mainly of photons with energies ≳ GeV, is too low. Contrary to this
point of view, we show that a large fraction of the black hole power at the final stage of evaporation (the last 103 s) can be liberated as a burst of soft γ-ray emission of duration 10−1–103 s and luminosity 1028–1031 erg/s in the energy range 0.1–1 MeV. According to our calculations of the black hole evaporation rate (within the Standard
Model of elementary particles), when the black hole temperature exceeds approximately 10 GeV, the charged particle outflow
from a black hole forms a well-defined plasma and can be described in the hydrodynamic approximation. In this case more than
half of the rest energy of a black hole can be converted into soft gamma-rays due to the presence of the magnetic field with
energy density comparable to that of charged particles. We consider various mechanisms leading to such transformation and
estimate their efficiency. It is shown that, at least, some of the gamma-ray bursts detected by BATSE can be associated with
evaporating black holes.
Institute of Applied Physics, Russian Academy of Sciences, Nizhny Novgorod, Russia. Translated from Izvestiya Vysshikh Uchebnykh
Zavedenii, Radiofizika, Vol. 41, No. 1, pp. 36–45, January, 1998. 相似文献
8.
9.
J. Badalec J. Ďatlov K. Jakubka VI. Kopecký Š. Körbel L. Kryška P. Magula J. Stöckel F. Žáček S. Nanobashvili 《Czechoslovak Journal of Physics》1983,33(7):787-790
The work is devoted to the study of the LH wave effect on the peripheral plasma of the TM-1-MH tokamak. The observed enhancement of the ion saturated current in the limiter shadow is interpreted as heating of the peripheral ions by absorption of decay waves generated in this region due to the nonlinear wave-plasma interaction. 相似文献
10.
S. I. Sidorenko A. M. Taratin S. A. Vorob'ev P. A. Kotsyumakha A. I. Kurlat B. M. Sobishchanskii A. G. Khotchenkov B. F. Minaev S. I. Galko E. A. Vasil'kovskaya V. V. Gorskii V. M. Lisitsyn A. Z. Éfendiev A. M. Yunusov S. A. Sadykov A. A. Aliverdiev T. A. Borodina T. S. Minakova V. I. Perov Yu. A. Tisenko Z. F. Dmitrenko V. V. Mikho V. Ya. Galin Yu. S. Makushkin A. I. Petrova VI. G. Tyuterev A. G. Yakunin G. A. Korablev 《Russian Physics Journal》1977,20(8):1116-1122