Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals

Russian Journal of General Chemistry - The binding of 68Ga to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and...     

2,5-Diamino-5,5-diphosphonovaleric Acid as a Ligand for an Osteotropic <Superscript>188</Superscript>Re Radiopharmaceutical

A modified method for the preparation of 2,5-diamino-5,5-diphosphonovaleric acid (DADP5) has been developed in the search for new synthetically available organic ligands to produce ¹⁸⁸Re radiopharmaceuticals with an increased accumulation in the bone tissue. Interaction of the obtained acid with ¹⁸⁸Re was studied by radio-TLC. An optimal system for separating unbound ¹⁸⁸Re and labeled complex in a yield of at least 95% was found. The biological distribution of ¹⁸⁸Re-DADP5 was studied based on direct radiometric data. The osteotropicity of ¹⁸⁸Re-DADP5 and its increased accumulation in bone fracture sites, which represent oncological pathology models, was detected at a level comparable to known radiopharmaceuticals.     

NMR study of 1,7-diamino-4-oxyheptane-1,1,7,7-tetraphosphonic acid interaction with samarium(III) cation

1,7-Diamino-4-oxypentane-1,1,7,7-tetraphosphonic acid has been synthesized while searching for potential components for ¹⁵³Sm radiopharmaceuticals. Its interaction with samarium(III) cation has been studied by ¹³C and ³¹P NMR spectroscopy in comparison with 1,5-diamino-3-oxypentane-N,N'-tetra-(methylenephosphonic acid) which is the ligand component of the osteotropic drug Samarium ¹⁵³Sm oxabifore. NMR spectroscopy provides a simple, convenient, and informative method for studying interactions between the ligand and prospective radionuclide cation.     

Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

Russian Chemical Bulletin - Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by...     

Effect of the [2-(diphenylphosphorylmethoxy)phenyl]diphenylphosphine oxide derivative structures on the extraction and ion-selective properties toward rare-earth elements

The effect of structures of the derivatives of [2-(diphenylphosphorylmethoxy)phenyl]-diphenylphosphine oxide (L¹) on the complexation properties toward rare-earth elements (REE) was studied. A new structural analogue of L¹, isopropyl 2-(diphenylphosphorylmethoxy)benzoate (L³), was synthesized. The extraction of REE by the carboxylated podand L³ in a 1,1,7-trihydrododecafluoroheptanol—water system with the HNO₃ concentration varied in a range from 1 to 6 mol L^?1 was studied. The stability constants of the neodymium(iii) and erbium(iii) nitrate complexes with L³ and 1-(methoxydiphenylphosphoryl)-2-diphenylphosphoryl-4-ethylbenzene (L²) and of lutetium(iii) nitrate and chloride complexes with L² in 1,1,7-trihydrododecafluorheptanol were determined. The properties of the membranes of the ion-selective electrodes based on L¹, L², and L³ toward REE cations were tested. The crystal structures of L³ and [NdL³(NO₃)₃(DMSO)₂] were determined by X-ray diffraction analysis.