Antihypothyroid Effect of Salidroside

In terms of prevalence, thyroid pathology, associated both with a violation of the gland function and changes in its structure, occupies one of the main places in clinical endocrinology. The problem of developing low-toxic and highly effective herbal preparations for the correction of thyroid hypofunction and its complications is urgent. Salidroside is a glucoside of tyrosol, found mostly in the roots of Rhodiola spp., and has various positive biological activities. The purpose of this study was to study the antihypothyroid potential of salidrosid-containing extract from R. semenovii roots, which was evaluated on a mercazolyl hypothyroidism model. We showed that extract containing salidroside is a safe and effective means of hypothyroidism correction, significantly reducing (p ≤ 0.001) the level of thyroid-stimulating hormone and increasing the level of thyroid hormones. The combined use of R. semenovii extract with potassium iodide enhances the therapeutic effect of the extract by 1.3-times.     

Efficient and safe medicines developed by Siberian scientists

Results of pharmacological and physico-chemical studies of supramolecular drug delivery systems on the basis of plant metabolites, viz. polysaccharides and glycyrrhizinic acid are summarized. The prospects of developing of safe and efficient medicines are outlined.     

Synthesis and analgesic activity of octahydro-2H-chromenols,derivatives of aliphatic ketones

Russian Chemical Bulletin - A series of compounds with a hydrogenated 2H-chromene skeleton was synthesized by the reaction of ketones and available para-menthane monoterpenoid (—)-isopulegol....     

Reaction of N-sulfinyltrifluoromethanesulfonamide with triphenylphosphine and triphenylphosphine oxide

The reaction of N-sulfinyltrifluoromethanesulfonamide with triphenylphosphine and triphenylphosphine oxide or of trifluoromethanesulfonamide with dichloro(triphenyl)phosphorane leads to trifluoro-N-(triphenyl-λ⁵-phosphanylidene)methanesulfonamide, which is hydrolyzed to trifluoromethanesulfonamide and triphenylphosphine oxide via the intermediate trifluoro-N-[hydroxy(triphenyl)phosphoranyl]methanesulfonamide.     

The reaction of <Emphasis Type="Italic">N</Emphasis>-sulfinyltrifluoromethanesulfonamide with triethylphosphate and triethylphosphite

The reaction of N-sulfinyltrifluoromethanesulfonamide CF₃SO₂NSO with triethylphosphate and triethylphosphite results in N-(trifluoromethanesulfonyl)triethoxyphosphazene CF₃SO₂N=P(OEt)₃, which upon heating is converted into the diethyl ester of N-trifluoromethylsulfonylamidophosphoric acid CF₃SO₂NHP(O)·(OEt)₂. The latter was also prepared by alcoholysis of N-(trifluoromethanesulfonyl)trichlorophosphazene or of potassium salt of dichloroanhydride of N-trifluoromethylsulfonylamidophosphoric acid, or by the reaction of the salt CF₃SO₂NHNa with diethylchlorophosphate. Compound CF₃SO₂N=P(OEt)₃ does not rearrange into the isomeric diethyl ester of N-ethyl-N-(trifluoromethylsulfonyl)amidophosphoric acid CF₃SO₂N(Et)P(O)(OEt)₂, contrary to the statement in the literature on the easy rearrangement of phosphazenes RFSO₂N=P(OEt)₃ into amidates RFSO₂N(Et)P(O)(OEt)₂.