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排序方式: 共有525条查询结果,搜索用时 15 毫秒
1.
Douglas R. Hurst Kristen L. French April J. Angel Angela R. Williams Mary E. Rampey Tina S. Guion Kam W. Chan Camille M. Kassis Shannon L. Studer Martinez Charles F. Beam 《Journal of heterocyclic chemistry》1998,35(6):1357-1359
Several acetoacetanilides were trilithiated in excess lithium diisopropylamide, and the resulting polylithiated intermediates were regioselectively condensed with lithiated methyl salicylates followed by acid cyclization to substituted 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides (benzopyranone-2-acetamides). 相似文献
2.
Stereochemistry of lactide polymerization with chiral catalysts: new opportunities for stereocontrol using polymer exchange mechanisms 总被引:7,自引:0,他引:7
The synthesis of chiral aluminum and yttrium alkoxides and their application for lactide polymerization are reported. The complexes (SalBinap)MOR [4, M = Al, R = (i)Pr; 5, M = Y, R = (CH(2))(2)NMe(2)] are synthesized by reacting the ligand (SalBinap)H(2) [2,2'-[(1,1'-binaphthalene)-2,2'-diylbis(nitrilomethylidyne)]bisphenol] with the appropriate metal trisalkoxide. While enantiomerically pure yttrium complex 5 did not effect stereocontrol in the polymerization of either meso- or rac-lactide, homochiral 4 was found to exhibit excellent stereocontrol in a range of lactide polymerizations. Enantiomerically pure 4 polymerizes meso-lactide to syndiotactic poly(lactic acid) (PLA), while rac-4 polymerizes meso- and rac-lactide to heterotactic and isotactic stereoblock PLA, respectively. On the basis of the absolute stereochemistry of ring-opening of meso-lactide using (R)-4, a polymer exchange mechanism is proposed to account for the PLA microstructures resulting from rac-4. 相似文献
3.
Liang X Parkinson JA Weishäupl M Gould RO Paisey SJ Park HS Hunter TM Blindauer CA Parsons S Sadler PJ 《Journal of the American Chemical Society》2002,124(31):9105-9112
As platforms for the design of metal-based therapeutic and diagnostic agents, macrocycles are rigid enough to provide strong metal binding sites and orient functional groups stereoselectively, yet flexible enough to accommodate structural changes required for induced-fit recognition of biological targets. We consider the recognition of the Zn(II) complex of the bis-tetraazamacrocycle xylyl-bicyclam, a potent anti-HIV agent, by the coreceptor CXCR4, a G-protein-coupled receptor used by HIV for membrane fusion and cell entry. NMR studies show that the macrocycles of Zn(II)(2)-xylyl-bicyclam perchlorate exist in aqueous solution as two major configurations, trans-I (nitrogen chirality R,S,R,S), and trans-III (S,S,R,R). Acetate addition induced a major structural change. X-ray crystallography shows that the acetate complex contains the unusual cis-V cyclam configuration (R,R,R,R and folded) with bidentate coordination of acetate to Zn(II) plus second-coordination-sphere double H-bond formation between diagonal NH protons on the opposite cyclam face and acetate carboxylate oxygens. Detailed 1D and 2D NMR studies show that the major configuration of Zn(II)(2)-xylyl-bicyclam acetate in aqueous solution is cis-V/trans-I. Molecular modeling shows that an analogous cis-V site can be formed when Zn(II)(2)-xylyl-bicyclam binds to CXCR4, involving the carboxylate groups of Asp262 (Zn(II) coordination) and Glu288 (double H-bonding). The second cyclam can adopt the trans-I (or trans-III) configuration with Zn(II) binding to Asp171. These interactions are consistent with the known structure-activity relationships for bicyclam anti-HIV activity and receptor mutation. Consideration of the anti-HIV activity of xylyl-bicyclam complexes of other metal ions suggests that affinity for carboxylates, configurational flexibility, and kinetic factors may all play roles in receptor recognition. For example, Pd(II) cyclam complexes interact only weakly with axial ligands and are inflexible and inactive, whereas Co(III) cyclams bind carboxylates strongly, are configurationally flexible, and yet have low activity. Our findings should aid the design of new generations of active macrocycles including highly specific chemokine receptor antagonists. 相似文献
4.
Amyes TL Diver ST Richard JP Rivas FM Toth K 《Journal of the American Chemical Society》2004,126(13):4366-4374
We report second-order rate constants kDO (M-1 s-1) for exchange for deuterium of the C(2)-proton of a series of simple imidazolium cations to give the corresponding singlet imidazol-2-yl carbenes in D2O at 25 degrees C and I = 1.0 (KCl). Evidence is presented that the reverse protonation of imidazol-2-yl carbenes by solvent water is limited by solvent reorganization and occurs with a rate constant of kHOH = kreorg = 10(11) s-1. The data were used to calculate reliable carbon acid pK(a)s for ionization of imidazolium cations at C(2) to give the corresponding singlet imidazol-2-yl carbenes in water: pKa = 23.8 for the imidazolium cation, pKa = 23.0 for the 1,3-dimethylimidazolium cation, pKa = 21.6 for the 1,3-dimethylbenzimidazolium cation, and pKa = 21.2 for the 1,3-bis-((S)-1-phenylethyl)benzimidazolium cation. The data also provide the thermodynamic driving force for a 1,2-hydrogen shift at a singlet carbene: K12 = 5 x 10(16) for rearrangement of the parent imidazol-2-yl carbene to give neutral imidazole in water at 298 K, which corresponds to a favorable Gibbs free energy change of 23 kcal/mol. We present a simple rationale for the observed substituent effects on the thermodynamic stability of N-heterocyclic carbenes relative to a variety of neutral and cationic derivatives that emphasizes the importance of the choice of reference reaction when assessing the stability of N-heterocyclic carbenes. 相似文献
5.
Accurate computer simulations of the rotational dynamics of linear molecules solvated in He clusters indicate that the large-size (nanodroplet) regime is attained quickly for light rotors (HCN) and slowly for heavy ones (OCS, N2O, and CO2), thus challenging previously reported results. Those results spurred the view that the different behavior of light rotors with respect to heavy ones-including a smaller reduction of inertia upon solvation of the former-would result from the lack of adiabatic following of the He density upon molecular rotation. We have performed computer experiments in which the rotational dynamics of OCS and HCN molecules was simulated using a fictitious inertia appropriate to the other molecule. These experiments indicate that the approach to the nanodroplet regime, as well as the reduction of the molecular inertia upon solvation, is determined by the anistropy of the potential, more than by the molecular weight. Our findings are in agreement with recent infrared and/or microwave experimental data which, however, are not yet totally conclusive by themselves. 相似文献
6.
Pochodzalla J Möhlenkamp T Rubehn T Schüttauf A Wörner A Zude E Begemann-Blaich M Blaich T Emling H Ferrero A Gross C Immé G Iori I Kunde GJ Kunze WD Lindenstruth V Lynen U Moroni A Müller WF Ocker B Raciti G Sann H Schwarz C Seidel W Serfling V Stroth J Trautmann W Trzcinski A Tucholski A Verde G Zwieglinski B 《Physical review letters》1995,75(6):1040-1043
7.
Frabetti PL Cheung HW Cumalat JP Dallapiccola C Ginkel JF Greene SV Johns WE Nehring MS Butler JN Cihangir S Gaines I Garbincius PH Garren L Gourlay SA Harding DJ Kasper P Kreymer A Lebrun P Shukla S Bianco S Fabbri FL Sarwar S Zallo A Culbertson R Gardner RW Greene R Wiss J Alimonti G Bellini G Caccianiga B Cinquini L Di Corato M Giammarchi M Inzani P Leveraro F Malvezzi S Menasce D Meroni E Moroni L Pedrini D Perasso L Sala A Sala S Torretta D Vittone M Buchholz D Claes D Gobbi B O'Reilly B 《Physical review letters》1993,71(6):827-830
8.
Frabetti PL Cheung HW Cumalat JP Dallapiccola C Ginkel JF Greene SV Johns WE Nehring MS Butler JN Cihangir S Gaines I Garren L Garbincius PH Gourlay SA Harding DJ Kasper P Kreymer A Lebrun P Shukla S Bianco S Fabbri FL Sarwar S Zallo A Culbertson R Gardner RW Greene R Wiss J Alimonti G Bellini G Caccianiga B Cinquini L Di Corato M Giammarchi M Inzani P Leveraro F Malvezzi S Menasce D Meroni E Moroni L Pedrini D Perasso L Sala A Sala S Torreta D Vittone M Buchholz D Claes D Gobbi B O'Reilly B 《Physical review letters》1993,70(14):2058-2061
9.
Frabetti PL Cheung HW Cumalat JP Dallapiccola C Ginkel JF Greene SV Johns WE Nehring MS Butler JN Cihangir S Gaines I Garren L Garbincius PH Gourlay SA Harding DJ Kasper P Kreymer A Lebrun P Shukla S Bianco S Fabbri FL Sarwar S Zallo A Culbertson R Gardner RW Greene R Wiss J Alimonti G Bellini G Caccianiga B Cinquini L Di Corato M Giammarchi M Inzani P Leveraro F Malvezzi S Menasce D Meroni E Moroni L Pedrini D Perasso L Sala A Sala S Torretta D Vittone M Buchholz D Claes D Gobbi B O'Reilly B 《Physical review letters》1993,70(10):1381-1384
10.
Frabetti PL Cheung HW Cumalat JP Dallapiccola C Ginkel JF Greene SV Johns WE Nehring MS Butler JN Cihangir S Gaines I Garren L Garbincius PH Gourlay SA Harding DJ Kasper P Kreymer A Lebrun P Shukla S Bianco S Fabbri FL Sarwar S Zallo A Culbertson R Gardner RW Greene R Wiss J Alimonti G Bellini G Caccianiga B Cinquini L Di Corato M Giammarchi M Inzani P Leveraro F Malvezzi S Menasce D Meroni E Moroni L Pedrini D Perasso L Sala A Sala S Toretta D Vittone M Buchholz D Claes D Gobbi B O'Reilly B 《Physical review letters》1993,70(12):1755-1758