Polycations. II. Chiral ammonium dendrimer synthesis

The preparation and investigation of chiral cationic dendrimers is described. In these species, cationic sites are provided by quaternary ammonium ion centers derived from the dinitrogen compound 1,4-diazabicyclo[2.2.2]octane (dabco). Stereogenic sites within the dendrimer structures are provided by derivitization of the readily available (S)-1,2,4-butanetriol. © 1998 John Wiley & Sons, Inc. Heteroatom Chem 9: 485–494, 1998     

Lewis acid-promoted addition of 1,3-bis(silyl)propenes to aldehydes: a route to 1,3-dienes

The Lewis acid-promoted addition of 1,3-bis(silyl)propenes to aldehydes to provide the corresponding (E)-1,3-dienes in excellent stereoselectivity and good to excellent yields is reported. The procedure is mild, base-free, and operationally straightforward.     

Synthesis of new sugar-based surfactants and evaluation of their hemolytic activities

The synthesis of four sugar-based surfactants derived from glucose and (R)-12-hydroxystearic acid is described. The surfactants have a hydroxy group in the hydrophobic part, which is either free or acylated using acetyl chloride, hexanoyl chloride, or myristoyl chloride. Three of the synthesized surfactants are water-soluble and are evaluated with respect to their CMCs and hemolytic activities. The fourth surfactant has limited water solubility and is not further included in the study. The investigated surfactants are all hemolytic close to their respective CMC indicating that their use in parenteral formulations may be limited. Nevertheless, surfactants having the proposed structure appear as promising alternatives to existing solubilizing agents for pharmaceutical applications.