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1.
Martin Kellert Jan-Simon Jeshua Friedrichs Nadine Anke Ullrich Alexander Feinhals Jonas Tepper Peter Lnnecke Evamarie Hey-Hawkins 《Molecules (Basel, Switzerland)》2021,26(7)
The development of novel, tumor-selective and boron-rich compounds as potential agents for use in boron neutron capture therapy (BNCT) represents a very important field in cancer treatment by radiation therapy. Here, we report the design and synthesis of two promising compounds that combine meta-carborane, a water-soluble monosaccharide and a linking unit, namely glycine or ethylenediamine, for facile coupling with various tumor-selective biomolecules bearing a free amino or carboxylic acid group. In this work, coupling experiments with two selected biomolecules, a coumarin derivative and folic acid, were included. The task of every component in this approach was carefully chosen: the carborane moiety supplies ten boron atoms, which is a tenfold increase in boron content compared to the l-boronophenylalanine (l-BPA) presently used in BNCT; the sugar moiety compensates for the hydrophobic character of the carborane; the linking unit, depending on the chosen biomolecule, acts as the connection between the tumor-selective component and the boron-rich moiety; and the respective tumor-selective biomolecule provides the necessary selectivity. This approach makes it possible to develop a modular and feasible strategy for the synthesis of readily obtainable boron-rich agents with optimized properties for potential applications in BNCT. 相似文献
2.
Prof. Dr. Steven Stevenson Amanda J. Rothgeb Katelyn R. Tepper Prof. Dr. James Duchamp Prof. Dr. Harry C. Dorn Xian B. Powers Mrittika Roy Prof. Dr. Marilyn M. Olmstead Prof. Dr. Alan L. Balch 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(54):12545-12551
Purified samples of Ho3N@C2(22010)-C78 and Tb3N@C2(22010)-C78 have been isolated by two distinct processes from the rich array of fullerenes and endohedral fullerenes present in carbon soot from graphite rods doped with Ho2O3 or Tb4O7. Crystallographic analysis of the endohedral fullerenes as cocrystals with Ni(OEP) (in which OEP is the dianion of octaethylporphyrin) shows that both molecules contain the chiral C2(22010)-C78 cage. This cage does not obey the isolated pentagon rule (IPR) but has two sites where two pentagons share a common C−C bond. These pentalene units bind two of the metal ions, whereas the third metal resides near a hexagon of the cage. Inside the cages, the Ho3N or Tb3N unit is planar. Ho3N@C2(22010)-C78 and Tb3N@C2(22010)-C78 use the same cage previously found for Gd3N@C2(22010)-C78 rather than the IPR-obeying cage found in Sc3N@D3h-C78. 相似文献
3.
In this paper, we construct a parallel image of the conventional Maxwell theory by replacing the observer-time by the proper-time of the source. This formulation is mathematically, but not physically, equivalent to the conventional form. The change induces a new symmetry group which is distinct from, but closely related to the Lorentz group, and fixes the clock of the source for all observers. The new wave equation contains an additional term (dissipative), which arises instantaneously with acceleration. This shows that the origin of radiation reaction is not the action of a charge on itself but arises from inertial resistance to changes in motion. This dissipative term is equivalent to an effective mass so that classical radiation has both a massless and a massive part. Hence, at the local level the theory is one of particles and fields but there is no self-energy divergence (nor any of the other problems). We also show that, for any closed system of particles, there is a global inertial frame and unique (invariant) global proper-time (for each observer) from which to observe the system. This global clock is intrinsically related to the proper clocks of the individual particles and provides a unique definition of simultaneity for all events associated with the system. We suggest that this clock is the historical clock of Horwitz, Piron, and Fanchi. At this level, the theory is of the action-at-a-distance type and the absorption hypothesis of Wheeler and Feynman follows from global conservation of energy. 相似文献
4.
Shi Xunqing Wang Zhiping John HL Pang Zhang Xueren Nie Jingxu 《Acta Mechanica Sinica》2002,18(3):274-287
In this study, a new unified creep constitutive relation and a modified energy-based fatigue model have been established respectively
to describe the creep flow and predict the fatigue life of Sn−Pb solders. It is found that the relation successfully elucidates
the creep mechanism related to current constitutive relations. The model can be used to describe the temperature and frequency
dependent low cycle fatigue behavior of the solder. The relation and the model are further employed in part II to develop
the numerical simulation approach for the long-term reliability assessment of the plastic ball grid array (BGA) assembly.
The project supported by the National Natural Science Foundation of China (59705008) 相似文献
5.
We construct a generalization of Maxwell's equations associated with the proper-time of the source which accounts for radiation reaction without any assumptions concerning the nature of the source. The theory leads to a new invariance group, related to the Lorentz group, which leaves the proper-time of the source fixed for all observers. 相似文献
6.
Tepper L. Gill Woodford W. Zachary James Lindesay 《International Journal of Theoretical Physics》1998,37(10):2573-2613
Our purpose in this paper is to provide theframework for a generalization of classical mechanicsand electrodynamics, including Maxwell's theory, whichis simple, technically correct, and requires noadditional work for the quantum case. We first show thatthere are two other definitions of proper-time, eachhaving equal status with the Minkowski definition. Weuse the first definition, called the proper-velocity definition, to construct a transformationtheory which fixes the proper-time of a given physicalsystem for all observers. This leads to a new invariancegroup and a generalization of Maxwell's equations left covariant under the action of this group.The second definition, called the canonical variablesdefinition, has the unique property that it isindependent of the number of particles. This definition leads to a general theory of directlyinteracting relativistic particles. We obtain theLorentz force for one particle (using its proper-time),and the Lorentz force for the total system (using theglobal proper-time). Use of the global proper-time tocompute the force on one particle gives the Lorentzforce plus a dissipative term corresponding to thereaction of this particle back on the cause of itsacceleration (Newton's third law). The wave equation derivedfrom Maxwell's equations has an additional term, firstorder in the proper-time. This term arisesinstantaneously with acceleration. This shows explicitly that the longsought origin of radiationreaction is inertial resistance to changes in particlemotion. The field equations carry intrinsic informationabout the velocity and acceleration of the particles in the system. It follows that our theory isnot invariant under time reversal, so that the existenceof radiation introduces an arrow for the (proper-time ofthe) system. 相似文献
7.
The interaction of the monooxygenating type-3 copper enzyme Tyrosinase (Ty) from Streptomyces antibioticus with its inhibitor p-nitrophenol (pnp) was studied by paramagnetic NMR methods. The pnp binds to oxidized Ty (Ty(met)) and its halide (F(-), Cl(-)) bound derivatives with a dissociation constant in the mM range. The Cu(2) bridging halide ion is not displaced upon the binding of pnp showing that the pnp does not occupy the Cu(2) bridging position. The binding of pnp to Ty(met) or Ty(met)Cl leads to localized changes in the type-3 (Cu-His(3))(2) coordination geometry reflecting a change in the coordination of a single His residue that, still, remains coordinated to Cu. The binding of pnp to Ty(met)Cl causes a decrease in the Cu(2) magnetic exchange parameter -2J from 200 cm(-)(1) in the absence to 150 +/- 10 cm(-)(1) in the presence of pnp. From the (1)H and (2)D NMR relaxation parameters of pnp bound to Ty(met), a structural model of pnp coordination to the Ty type-3 center could be derived. The model explains the absence of hydroxylase activity in the closely related type-3 copper protein catechol oxidase. The relevance of the experimental findings toward the Ty catalytic mechanism is discussed. 相似文献
8.
Multistate empirical valence bond and classical molecular dynamics simulations were used to explore mechanisms for passive ion leakage through a dimyristoyl phosphatidylcholine lipid bilayer. In accordance with a previous study on proton leakage (Biophys. J. 2005, 88, 3095), it was found that the permeation mechanism must be a highly concerted one, in which ion, solvent, and membrane coordinates are coupled. The presence of the ion itself significantly alters the response of those coordinates, suggesting that simulations of transmembrane water structures without explicit inclusion of the ionic solute are insufficient for elucidating transition mechanisms. The properties of H(+), Na(+), OH(-), and bare water molecules in the membrane interior were compared, both by biased sampling techniques and by constructing complete and unbiased transition paths. It was found that the anomalous difference in leakage rates between protons and other cations can be largely explained by charge delocalization effects rather than the usual kinetic picture (Grotthuss hopping of the proton). Permeability differences between anions and cations through phosphatidylcholine bilayers are correlated with suppression of favorable membrane breathing modes by cations. 相似文献
9.
10.
Multistate empirical valence bond simulations were employed to study proton transport through gramicidin A channels embedded in two different lipid bilayers, glycerol 1-monooleate (GMO) and diphytanolphosphatidylcholine (DiPhPC). Free energy barriers to proton permeation were derived using a new internal reaction coordinate describing the proton permeation process. The large quantitative and qualitative differences between the two systems are discussed in terms of local bilayer structures, ordering of interfacial water, and channel flexibility in the two environments. 相似文献