Rapid biomass analysis

New, rapid, and inexpensive methods that monitor the chemical composition of corn stover and corn stover-derived samples are a key element to enabling the commercialization of processes that convert stover to fuels and chemicals. These new techniques combine near infrared (NIR) spectroscopy and projection to latent structures (PLS) multivariate analysis to allow the compositional analysis of hundreds of samples in 1 d at a cost of about $10 each. The new NIR/PLS rapid analysis methods can also be used to support a variety of research projects that would have been too costly to pursue by traditional methods.     

Waiting time in a multi-server cutoff-priority gueue, and its application to an urban ambulance service

We consider a priority queue in steady state with N servers, two classes of customers, and a cutoff service discipline. Low priority arrivals are "cut off" (refused immediate service) and placed in a queue whenever N1 or more servers are busy, in order to keep N-N1 servers free for high priority arrivals. A Poisson arrival process for each class, and a common exponential service rate, are assumed. Two models are considered: one where high priority customers queue for service and one where they are lost if all servers are busy at an arrival epoch. Results are obtained for the probability of n servers busy, the expected low priority waiting time, and (in the case where high priority customers do not queue) the complete low priority waiting time distribution. The results are applied to determine the number of ambulances required in an urban fleet which serves both emergency calls and low priority patients transfers.     

An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology

The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system is best known for its role in genomic editing. It has also demonstrated great potential in nucleic acid biosensing. However, the specificity limitation in CRISPR/Cas has created a hurdle for its advancement. More recently, nucleic acid aptamers known for their high affinity and specificity properties for their targets have been integrated into CRISPR/Cas systems. This review article gives a brief overview of the aptamer and CRISPR/Cas technology and provides an updated summary and discussion on how the two distinctive nucleic acid technologies are being integrated into modern diagnostic and therapeutic applications     

Methyl/ethyl differentiation in diastereoselective hydride addition to [Tp'W(CO)(PhCCMe)(NH=CMeEt)][BAr'(4)

Hydride addition to either an 80:20 or a 93:7 E/Z isomer ratio of coordinated imine complex 2a occurs with high diastereoselectivity. The high diastereoselectivity regardless of the reagent E/Z ratio is explained by a difference between the relative kinetic acidities of the E and Z isomers of the imine complex. The kinetic acidities of related isopropylimine and 3-pentylimine complexes were used in explaining these results.     

The service system M/M R /∞ with impatient customers

An infinite server queue is considered where customers have a choice of individual service or batch service. Transient results have been obtained for the first two moments of the system size distribution. Waiting time distribution is important in system evaluation and steady state results are obtained.     

Numerical analysis for bulk-arrival queueing systems: Root-finding and steady-state probabilities inGI r /M/1 queues

Queueing theorists have presented, as solutions to many queueing models, probability generating functions in which state probabilities are expressed as functions of the roots of characteristic equations, evaluation of the roots in particular cases being left to the reader. Many users have complained that such solutions are inadequate. Some queueing theorists, in particular Neuts [6], rather than use Rouché's theorem to count roots and an equation-solver to find them, have developed new algorithms to solve queueing problems numerically, without explicit calculation of roots. Powell [7] has shown that in many bulk service queues arising in transportation models, characteristic equations can be solved and state probabilities can be found without serious difficulty, even when the number of roots to be found is large. We have slightly modified Powell's method, and have extended his work to cover a number of bulk-service queues discussed by Chaudhry et al. [1] and a number of bulk-arrival queues discussed in the present paper.