A novel antimicrobial triterpenic acid from the leaves of Ficus benjamina (var. comosa)

The chloroform extract of the leaves of Ficus benjamina (var. comosa) (Moraceae) afforded a new triterpenic acid named as (9,11), (18,19)-disecoolean-12-en-28-oic acid (1) along with β-amyrin (2). Their structures were established on the basis of chemical and physical evidences (IR, ¹H NMR, and MS data). The compound 1 exhibited significant antimicrobial activity against Salmonella typhimurium (MTCC-98), Candida albicans (IAO-109), Staphylococcus aureus (IAO-SA-22), Escherichia coli (K-12) and low activity against Aspergillus niger (lab isolate ICAR) and Aspergillus brassicola.     

CHLOROSULFONATION OF N-PHENYLMORPHOLINE,BENZOTHIAZOLE, 2-METHYL BENZOTHIAZOLE AND TRIPHENYLOXAZOLE

Abstract

N-Phenylmorpholine (1) reacted with chlorosulfonic acid to give the p-sulfonyl chloride (2), which was characterized as the sulfonamides (3–5). Benzothiazole (6) was converted into the sulfonyl chloride (7) by sequential treatment with hot chlorosulfonic acid and thionyl chloride. Reaction of (7) with amines afforded the derivatives (8–10); NMR spectral analysis of the dimethylamide (8) indicated that it was a mixture of the 4- and 7-isomers. Chlorosulfonation of 2-methylbenzothiazole (11) was achieved by heating with chlorosulfonic acid with or without thionyl chloride. The chloride (12) was converted into amides (13–19). Study of the NMR spectra indicated that mixtures of the 5- and 6-isomers were formed. 2,4,5-Triphenyloxazole (20) reacted with chlorosulfonic acid to give either the mono-(21), bis (23) or bis-tris sulfonylchlorides (23, 34); these were converted into 14 sulfonamides. 2-(p-Nitrophenyl)-4,5-diphenyloxazole (41) reacted with hot chlorosulfonic acid to give the bis-sulfonyl chloride (42), characterized as the dimethylsulfonamide (43). Attempts to form the pure monosulfonyl chloride and to mono nitrate 2,4,5-triphenyloxazole (20) were unsuccessful.     

Highly ordered polymer films of amphiphilic, regioregular polythiophene derivatives

The fabrication and characterization of highly ordered thin films made from amphiphilic, regioregular polythiophene derivatives are described. Films of poly(3-(11-(2-tetrahydropyranyloxy)undecyl)thiophene (PTHPUDT) were prepared by the Langmuir-Blodgett technique. The amphiphilic nature of the polymer affords layer-by-layer deposition and the formation of multilayer films of head-to-head and tail-to-tail Y-type structure. X-ray diffraction studies indicate bilayer separations of approximately 30 A. Anisotropic optical absorption in the plane of the film indicates that the thiophene backbones are preferentially oriented along the dipping direction. Further, polarized light microscopy studies indicate that these films are highly birefringent and that the optical retardation is uniform over the entire film. Ellipsometry studies confirm the sizable magnitude of the birefringence. Optical second-harmonic generation studies of multilayer films provide information regarding both the thiophene orientation within the film and the anisotropic distribution of chromophores in the surface plane. Taken together, these data offer strong evidence of highly ordered films in which the hydrophobic polythiophene chains lie parallel to the substrate surface with their alkyl chains oriented normal to the surface, as dictated by the hydrophilic nature of the alkyl chain's terminal tetrahydropyran functional group. As such, these films offer the potential for elucidating the connection between polymer morphology and physical property in materials that are otherwise subject to a sufficiently complex distribution of morphologies that such a correspondence is precluded.     

Total bremsstrahlung spectra in targets of Al,Ti, Sn and Pb produced by complete absorption of 90Sr β particles

Total bremsstrahlung (BS) spectra in thick targets of Al, Ti, Sn and Pb produced by complete absorption of ⁹⁰Sr β particles (0–546 keV) are reported in the photon energy region of 10–30 keV. The experimental BS spectral photon distributions were compared with the theoretical BS spectral photon distributions obtained from Elwert corrected (non‐relativistic) Bethe–Heitler theory, modified Elwert factor (relativistic) Bethe–Heitler theories for ordinary bremsstrahlung (OB) and the modified Elwert factor (relativistic) Bethe–Heitler theory, which include the polarization bremsstrahlung (PB) into OB in stripped atom approximation. It has been observed that the experimental results are showing better agreement with the modified Elwert factor (relativistic) Bethe–Heitler theory having the contribution of PB at photon energy from 10 to 30 keV. This indicates the importance of PB in BS spectra, while studying the spectral photon distributions produced by continuous β particles having energy range of 0–546 keV in thick metallic targets. Further, it is observed that the contribution of PB into OB increases with increase in atomic number of the target and decreases with increase in photon energy. Copyright © 2010 John Wiley & Sons, Ltd.     

Role of polarization Bremsstrahlung in the formation of thick target Bremsstrahlung spectra in the energy range of 5–10 keV

Role of polarization Bremsstrahlung in the formation of total Bremsstrahlung (BS) spectra in thick targets of Al, Ti, Sn and Pb, produced by complete absorption of ⁹⁰Sr beta particles having an energy range of 0–546 keV, are studied in the photon energy region of 5 to 10 keV. The theoretical BS spectral photon distributions, obtained from Elwert corrected (nonrelativistic) Bethe–Heitler theory, a modified Elwert factor (relativistic) Bethe–Heitler theory that describe ordinary Bremsstrahlung (OB) and a modified Elwert factor (relativistic) Bethe–Heitler theory for BS spectra that includes the polarization Bremsstrahlung (PB) into OB in stripped atom approximation, were compared with the experimentally measured BS spectral photon distributions. It has been observed that the experimental results are in agreement with the modified Elwert factor (relativistic) Bethe–Heitler theory at photon energy from 5 to 10 keV. It has been also observed that the contribution of PB into OB decreases with increase in end‐point energy of beta emitter and the energy of the emitted photon. Further, it has been found that the contribution of PB into OB increases with increase in atomic number of the target atom. This indicates the importance of PB in the formation of BS produced by continuous beta particle. Copyright © 2012 John Wiley & Sons, Ltd.     

Some new radiating Kerr-Newman solutions

Three exact non-static solutions of Einstein-Maxwell equations corresponding to a field of flowing null radiation plus an electromagnetic field are presented. These solutions are non-static generalizations of the well known Kerr-Newman solution. The current vector is null in all the three solutions. These solutions are the electromagnetic generalizations of the three generalized radiating Kerr solutions discussed by Vaidya and Patel. The solutions discussed by us describe the exterior gravitational fields of rotating radiating charged bodies. Many known solutions are derived as particular cases.     

Influence of Helium-Neon Laser Irradiation on Seed Germination In Vitro and Physico-Biochemical Characters in Seedlings of Brinjal (Solanum melongena L.) var. Mattu Gulla

In the present study, the seeds of brinjal (Solanum melongena L.) var. Mattu Gulla were irradiated with single exposure of He–Ne laser at different doses of 5–40 J cm^?2 and germinated aseptically. Thirty day old seedlings were harvested and the germination, growth, physiological and biochemical parameters were estimated and compared with un‐irradiated control seedlings. A significant enhancement in growth characters were noted with respect to length, fresh and dry weight of shoots and roots. In addition, chlorophyll (a and b), carotenoid content, anthocyanin and amylases (α and β) activities were found to be altered. Significant alterations in percentage of seed germination (P < 0.001) and time to 50% germination (P < 0.001) were observed in the irradiated seeds compared with the un‐irradiated controls. In conclusion, the results of the present study demonstrated that low dose (5–30 J cm^?2) of He–Ne laser irradiation enhanced the germination process and altered growth, by positively influencing physiological and biochemical parameters of the brinjal seedlings compared with un‐irradiated control under in vitro conditions.