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1.
Laurens Kooijman Dr. Matthias Schuster Christian Baumann Simon Jurt Dr. Frank Löhr Dr. Boris Fürtig Prof. Dr. Peter Güntert Prof. Dr. Oliver Zerbe 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(47):21151-21158
To achieve efficient proton pumping in the light-driven proton pump bacteriorhodopsin (bR), the protein must be tightly coupled to the retinal to rapidly convert retinal isomerization into protein structural rearrangements. Methyl group dynamics of bR embedded in lipid nanodiscs were determined in the dark-adapted state, and were found to be mostly well ordered at the cytosolic side. Methyl groups in the M145A mutant of bR, which displays only 10 % residual proton pumping activity, are less well ordered, suggesting a link between side-chain dynamics on the cytosolic side of the bR cavity and proton pumping activity. In addition, slow conformational exchange, attributed to low frequency motions of aromatic rings, was indirectly observed for residues on the extracellular side of the bR cavity. This may be related to reorganization of the water network. These observations provide a detailed picture of previously undescribed equilibrium dynamics on different time scales for ground-state bR. 相似文献
2.
Astrid Baumann 《Mathematische Semesterberichte》1998,45(2):167-188
Zusammenfassung. Mit Hilfe der projektiven Geometrie werden neuartige Summationsformeln hergeleitet, die die Tschebyscheff-Polynome und modifizierte Polynome enthalten; z. B. gilt für alle :
Daraus ergeben sich wiederum interessante Summationsformeln für die Hyperbelfunktionen; es gilt z. B. für positive reelle
Zahlen t:
Eingegangen am 28.02.96, revidierte Fassung am 25.08.97 / Angenommen am 09.10.97 相似文献
3.
Received December 31, 2001 / Published online May 21, 2002 相似文献
4.
Velislava A Ignatova Sven Van Den Berghe Steven Van Dyck Vladimir N Popok 《Microscopy and microanalysis》2006,12(5):432-437
The oxide scales of AISI 304 formed in boric acid solutions at 300 degrees C and pH = 4.5 have been studied using X-ray photoelectron spectroscopy (XPS) depth profiling. The present focus is depth profile quantification both in depth and chemical composition on a molecular level. The roughness of the samples is studied by atomic force microscopy before and after sputtering, and the erosion rate is determined by measuring the crater depth with a surface profilometer and vertical scanning interferometry. The resulting roughness (20-30 nm), being an order of magnitude lower than the crater depth (0.2-0.5 microm), allows layer-by-layer profiling, although the ion-induced effects result in an uncertainty of the depth calibration of a factor of 2. The XPS spectrum deconvolution and data evaluation applying target factor analysis allows chemical speciation on a molecular level. The elemental distribution as a function of the sputtering time is obtained, and the formation of two layers is observed-one hydroxide (mainly iron-nickel based) on top and a second one deeper, mainly consisting of iron-chromium oxides. 相似文献
5.
Hai Huyen Dam Hans-Jürgen Zepernick Sven Nordholm Jörgen Nordberg 《Annals of Operations Research》2005,133(1-4):249-264
The performance of a code division multiple access system depends on the correlation properties of the employed spreading
code. Low cross-correlation values between spreading sequences are desired to suppress multiple access interference and to
improve bit error performance. An auto-correlation function with a distinct peak enables proper synchronization and suppresses
intersymbol interference. However, these requirements contradict each other and a trade-off needs to be established. In this
paper, a global two dimensional optimization method is proposed to minimize the out-of-phase average mean-square aperiodic
auto-correlation with average mean-square aperiodic cross-correlation being allowed to lie within a fixed region. This approach
is applied to design sets of complex spreading sequences. A design example is presented to illustrate the relation between
various correlation characteristics. The correlations of the obtained sets are compared with correlations of other known sequences. 相似文献
6.
7.
The association constant K of mono-acetato complex of Tb3+ has been determined at normal p and T conditions by measurement of its luminescence lifetime in aqueous solution containing increasing concentrations of acetate. Two experimental arrangements used for the measurement are described. 相似文献
8.
Analytical and Bioanalytical Chemistry - 相似文献
9.
Sulfur(IV) Compounds as Ligands. II. The Crystal and Molecular Structure of Pentacarbonyl--(sulfur dioxide)chromium The structure of pentacarbonyl(sulfurdioxide)chromium ( 1 ) has been determined from single crystal X-ray data. The compound crystallizes with eight formula units in the rhombic unit cell (space group Pbn21) of the dimensions a = 657.8(2) pm, b = 1245.2(4) pm, c = 2177.4(5) pm (at 180 K). The sulfur dioxide is η1-coplanar coordinated, the Cr? S distance is 219 pm, the shortest bond reported so far between chromium(0) and sulfur. The Cr? C(ax) bond (189 pm) was found only marginally shorter than the Cr? C(eq) bonds (190 pm) providing proof of the high π-acceptor capacity of SO2. 相似文献
10.
Leva S Lichte A Burmeister J Muhn P Jahnke B Fesser D Erfurth J Burgstaller P Klussmann S 《Chemistry & biology》2002,9(3):351-359
Mirror-image oligonucleotide ligands (Spiegelmers) that bind to the pharmacologically relevant target gonadotropin-releasing hormone I (GnRH) with high affinity and high specificity have been identified using the Spiegelmer technology. GnRH is a decapeptide that plays an important role in mammalian reproduction and sexual maturation and is associated with several benign and malignant diseases. First, aptamers that bind to D-GnRH with dissociation constants of 50-100 nM were isolated out of RNA and DNA libraries. The respective enantiomers of the DNA and RNA aptamers were synthesized, and their binding to L-GnRH was shown. These Spiegelmers bind to L-GnRH with similar affinity to that of the corresponding aptamers that bind to D-GnRH. We further demonstrated dose-dependent inhibition of GnRH-induced Ca(2+) release in Chinese hamster ovary cells that were stably transfected with the human GnRH receptor. 相似文献