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1.
Sekarpandi Sakthivel Suribabu Jammi Tharmalingam Punniyamurthy 《Tetrahedron: Asymmetry》2012,23(2):101-107
Stereoregular non-linear chiral main chain polymers 1a–b bonded alternatively with (R,R)-salen and 1,4-diethynyl-2,5-dioctyloxybenzene moieties have been synthesized using palladium catalyzed C–C cross-coupling and Schiff base formation reactions as the key steps. These polymers are soluble in common organic solvents, and act as an effective chemosensor for the detection of Zn2+ with respect to other metal ions with enhanced fluorescence. The CD spectra observed for the polymers 1a–b could be attributed to the helical secondary structure with a low degree of inter-strand interactions. This reduced inter-strand interaction has been ascertained from the titration of pyridine to the Zn(II)-polymer 1b complex, which results in minor changes in the fluorescence emission. 相似文献
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Francescone David Akula Sujeet Altunkaynak Baris Nath Pran 《Journal of High Energy Physics》2015,2015(1):1-48
Journal of High Energy Physics - We consider the AdS 2 /CFT 1 holographic correspondence near the horizon of rotating five-dimensional black holes preserving four supersymmetries in $$... 相似文献
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Hee-Jeong Cha Se-Yeun Hwang Da-Som Lee Dr. Akula Ravi Kumar Prof. Dr. Yong-Uk Kwon Moritz Voß Eva Schuiten Prof. Dr. Uwe T. Bornscheuer Prof. Dr. Frank Hollmann Prof. Dr. Deok-Kun Oh Prof. Dr. Jin-Byung Park 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(18):7090-7094
Long-chain aliphatic amines such as (S,Z)-heptadec-9-en-7-amine and 9-aminoheptadecane were synthesized from ricinoleic acid and oleic acid, respectively, by whole-cell cascade reactions using the combination of an alcohol dehydrogenase (ADH) from Micrococcus luteus, an engineered amine transaminase from Vibrio fluvialis (Vf-ATA), and a photoactivated decarboxylase from Chlorella variabilis NC64A (Cv-FAP) in a one-pot process. In addition, long chain aliphatic esters such as 10-(heptanoyloxy)dec-8-ene and octylnonanoate were prepared from ricinoleic acid and oleic acid, respectively, by using the combination of the ADH, a Baeyer–Villiger monooxygenase variant from Pseudomonas putida KT2440, and the Cv-FAP. The target compounds were produced at rates of up to 37 U g−1 dry cells with conversions up to 90 %. Therefore, this study contributes to the preparation of industrially relevant long-chain aliphatic chiral amines and esters from renewable fatty acid resources. 相似文献
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Gagan Chhabra Chandra K. Singh Deeba Amiri Neha Akula Nihal Ahmad 《Molecules (Basel, Switzerland)》2021,26(5)
Immunomodulation of the tumor microenvironment is emerging as an important area of research for the treatment of cancer patients. Several synthetic and natural agents are being investigated for their ability to enhance the immunogenic responses of immune cells present in the tumor microenvironment to impede tumor cell growth and dissemination. Among them, resveratrol, a stilbenoid found in red grapes and many other natural sources, has been studied extensively. Importantly, resveratrol has been shown to possess activity against various human diseases, including cancer. Mechanistically, resveratrol has been shown to regulate an array of signaling pathways and processes involving oxidative stress, inflammation, apoptosis, and several anticancer effects. Furthermore, recent research suggests that resveratrol can regulate various cellular signaling events including immune cell regulation, cytokines/chemokines secretion, and the expression of several other immune-related genes. In this review, we have summarized recent findings on resveratrol’s effects on immune regulatory cells and associated signaling in various cancer types. Numerous immunomodulatory effects of resveratrol suggest it may be useful in combination with other cancer therapies including immunotherapy for effective cancer management. 相似文献
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K. Raghavendra Rao Akula Raghunadh Ramamohan Mekala Suresh Babu Meruva T.V. Pratap T. Krishna Dipak Kalita Eppakayala Laxminarayana Bagineni Prasad Manojit Pal 《Tetrahedron letters》2014
A dual reactant/catalyst role of glyoxylic acid in the reaction of isatoic anhydride with various amines afforded a novel, robust and rapid synthesis of 3-(un)substituted quinazolin-4(3H)-ones. This metal catalyst-free reaction proceeds via an unusual and unexpected cleavage of C–C bond. A shorter and common route to two alkaloids, that is, rutaecarpine and evodiamine is also accomplished. 相似文献
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M.V. Madhubabu R. Shankar T. Krishna Y. Satish Kumar Y. Chiranjeevi Ch. Muralikrishna H. Rama Mohan Satish S. More M.V. Basaveswara Rao Raghunadh Akula 《Tetrahedron: Asymmetry》2017,28(12):1803-1807
A convergent approach towards the synthesis of the 2-alkyl-substituted tetrahydroquinoline alkaloid (?)-cuspareine via enantiospecific construction of the (R)-benzyl 2-formyl-3,4-dihydroquinoline-1(2H)-carboxylate. We have achieved an efficient enantiospecific synthesis of (?)-cuspareine starting from known key starting materials. The reactions employed for individual transformations are simple and high yielding, and the strategy could potentially be easily extended. 相似文献
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A facile synthesis of aryl and heteroaryl iodides from water-soluble complexes of aryl- and heteroarylboronic acids has been developed. 相似文献
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Synthesis and Antimicrobial Activity of Amido Sulfonamido Methane Linked Bisoxazoles,Bisthiazoles, and Bisimidazoles 下载免费PDF全文
Chokkappagari Premakumari Dandu Seenaiah Akula Srilakshmi Divi Venkata Ramana Sai Gopal Venkatapuram Padmavathi 《Journal of heterocyclic chemistry》2014,51(6):1875-1882
A new class of amido sulfonamido methane linked bisoxazoles, bisthiazoles, and bisimidazoles were prepared adopting simple and versatile synthetic methodologies. The lead compounds were assayed for antimicrobial activity. 相似文献
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The cycloaddition of o-quinodimethane, from 1,3-dihydrobenzo(c)-S,S dioxide, to 5,6-dihydroquinoline yields a mixture of adducts isomeric at the newly created ring junction. The cycloadducts can be dehydrogenated to the fully aromatic 1-azabenzanthracene. 相似文献