排序方式: 共有1条查询结果,搜索用时 15 毫秒
1
1.
Wanvimol Pasanphan Pakjira Rimdusit Surakarn Choofong Thananchai Piroonpan Sunchai Nilsuwankosit 《Radiation Physics and Chemistry》2010,79(10):1095-1102
The present investigation is mainly focused on the systematic preparation of chitosan nanoparticle in the potential range 1–100 nm using γ-ray irradiation. The effect of irradiation conditions in terms of physical form of chitosan, i.e. flake, colloidal and acidic solution, and γ-ray dose was studied. The molecular weights of chitosan were 10, 25, and >1000 times reduced when irradiated with the γ-ray dose as high as 100 kGy in Chi-flake, Chi-colloid, and Chi-acid, respectively. The particle size reduced to 70 nm after being irradiated to only 10 kGy γ-rays and it showed a tendency to decrease when the γ-ray doses were increased. The γ-rays effectively induced the reduction of chitosan particle size to <100 nm with narrow size distribution. The effective size reduction was particularly observed in Chi-colloid. Heterogeneous chemical conjugation of deoxycholic acid onto 10 kGy irradiated Chi-colloid resulted in narrow particle size as small as 50 nm. 相似文献
1