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Jacqueline De Souza Eunice Kazue Kano Eunice Emiko Mori Koono Simone Grigoleto Schramm Valentina Porta Sílvia Storpirtis 《Chromatographia》2009,69(2):231-235
This study describes an accurate, sensitive, and specific chromatographic method for the simultaneous quantitative determination of lamivudine and zidovudine in human blood plasma, using stavudine as an internal standard. The chromatographic separation was performed using a C8 column (150 × 4.6 mm, 5 μm), and ultraviolet absorbency detection at 270 nm with gradient elution. Two mobile phases were used. Phase A contained 10 mM potassium phosphate and 3% acetonitrile, whereas Phase B contained methanol. A linear gradient was used with a variability of A-B phase proportion from 98–2% to 72–28%, respectively. The drug extraction was performed with two 4 mL aliquots of ethyl acetate. 相似文献
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De Souza Jacqueline Kano Eunice Kazue Koono Eunice Emiko Mori Schramm Simone Grigoleto Porta Valentina Storpirtis S&#;lvia 《Chromatographia》2008,69(2):231-235
This study describes an accurate, sensitive, and specific chromatographic method for the simultaneous quantitative determination of lamivudine and zidovudine in human blood plasma, using stavudine as an internal standard. The chromatographic separation was performed using a C8 column (150 × 4.6 mm, 5 μm), and ultraviolet absorbency detection at 270 nm with gradient elution. Two mobile phases were used. Phase A contained 10 mM potassium phosphate and 3% acetonitrile, whereas Phase B contained methanol. A linear gradient was used with a variability of A-B phase proportion from 98–2% to 72–28%, respectively. The drug extraction was performed with two 4 mL aliquots of ethyl acetate.
相似文献
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