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Jean-Noël Marsat Frank Stahlhut André Laschewsky Hans v. Berlepsch Christoph Böttcher 《Colloid and polymer science》2013,291(11):2561-2567
An amphiphilic linear ternary block copolymer was synthesised in three consecutive steps via reversible addition–fragmentation chain transfer polymerisation. Oligo(ethylene glycol) monomethyl ether acrylate was engaged as a hydrophilic building block, while benzyl acrylate and 3-tris(trimethylsiloxy)silyl propyl acrylate served as hydrophobic building blocks. The resulting “triphilic” copolymer consists thus of a hydrophilic (A) and two mutually incompatible “soft” hydrophobic blocks, namely, a lipophilic (B) and a silicone-based (C) block, with all blocks having glass transition temperatures well below 0 °C. The triphilic copolymer self-assembles into spherical multicompartment micellar aggregates in aqueous solution, where the two hydrophobic blocks undergo local phase separation into various ultrastructures as evidenced by cryogenic transmission electron microscopy. Thus, a silicone-based polymer block can replace the hitherto typically employed fluorocarbon-based hydrophobic blocks in triphilic block copolymers for inducing multicompartmentalisation. 相似文献
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Zero-valent palladium precatalysts containing rigid bidentate bis(arylimino)acenaphthene ligands (shown schematically) facilitate the highly stereoselective homogeneous catalytic hydrogenation of alkynes to (Z)-alkenes. Internal, terminal, aryl-substituted, and cyclic alkynes are suitable substrates, as are some enynes, which are chemoselectively hydrogenated to dienes. E=CO(2)Me; R(1), R(2)=4-OCH(3), 4-CH(3), 2,6-(CH(3))(2). 相似文献
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The sensitivity of all ion trap mass spectrometry (ITMS) methods is dependent on the trapping efficiency of the instrument. For ITMS instruments utilizing external ion sources, such as laser desorption, trapping efficiency is known to depend on the phase and amplitude of the radio frequency (RF) potential applied to the ring electrode at the time of ion introduction. It is remarkable that, in a considerable body of literature, no consensus exists regarding the effects of these parameters on the efficacy of trapping externally generated ions. In this paper, a summary of the literature is presented in order to highlight significant discrepancies. New laser desorption ion trap mass spectrometry (LD-ITMS) data are also presented, from which conclusions are drawn in our effort to clarify some of the confusion. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
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The design, fabrication, and testing of photoelastic models of double-lap, multiple-pin connectors are discussed. Interest
is in the stresses in the inner laps. These stresses are determined by constructing models with photoelastic inner laps and
transparent-acrylic outer laps. The connectors have two pins, in tandem, parallel to the load direction. A photoelastic-isotropic
point is shown to permit the evaluation of load sharing between the two pins. A numerical scheme, utilizing the isochromatic-
and isoclinic-photoelastic data and a finite-difference representation of the planestress equilibrium equations, is used to
compute the stresses around the two pins. Representative stress distributions and stress-concentration factors are shown. 相似文献
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Liverton NJ Holloway MK McCauley JA Rudd MT Butcher JW Carroll SS DiMuzio J Fandozzi C Gilbert KF Mao SS McIntyre CJ Nguyen KT Romano JJ Stahlhut M Wan BL Olsen DB Vacca JP 《Journal of the American Chemical Society》2008,130(14):4607-4609
Molecular modeling of inhibitor bound full length HCV NS3/4A protease structures proved to be a valuable tool in the design of a new series of potent NS3 protease inhibitors. Optimization of initial compounds provided 25a. The in vitro activity and selectivity as well as the rat pharmacokinetic profile of 25a compare favorably with the data for other NS3/4A protease inhibitors currently in clinical development for the treatment of HCV. 相似文献
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JohnA. McCauley MichaelT. Rudd KevinT. Nguyen CharlesJ. McIntyre JosephJ. Romano KimberlyJ. Bush SandorL. Varga CharlesW. Ross StevenS. Carroll Jillian DiMuzio MarkW. Stahlhut DavidB. Olsen TerryA. Lyle JosephP. Vacca NigelJ. Liverton 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2008,120(47):9244-9247
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