Triflic Acid-Promoted Formylation of Ceramide in Dimethylformamide

The protected ceramide: N‐((2S,3S,4R)‐3,4‐bis(benzyloxy)‐1‐hydroxyoctadecan‐2‐yl)tetracosanamide, was attempted to introduce a triflate as a leaving group followed by a nucleophilic substitution with azido group in one‐pot manner. Unexpectedly, the oxazole ring formed via a thermodynamically favored intramolecular cyclization was opened to generate the original ceramide by triflic acid. In addition, the residual acid promoted a formylation of the primary hydroxy group in DMF.     

核子与氘核散射中的极化

利用转动、反射及时间反演的不变性,求得核子与氘核散射中极化的一般公式,并且把所得的结果通过散射相移表示出来。     

Quantum Stimulated Raman Scattering

The quantum field theory of stimulated Raman scattering is formulated. It is shown to give the correct classical limit. Ilowever, the quantum growth rate is bigger. An additional physical process of creation of two plasmons from two photons is intrinsically predicted by the theory.     

CORONA DISCHARGE OF MULTI-WIRE PROPORTIONAL CHAMBERS

In this report,the stable corona discharge region of multi-wire proportional cham-ber（MWPC）has been measured.In this region we observed double peak pheno- menon in Fe⁵⁵ pulse amplitude distribution,and establish the fact that,once cornadischarge region is present in MWPC,the spatial resolution power for light partic-les will be lost.     

MEASUREMENTS OF NUMBER OF RADIOACTIVE ATOMS AND HALF-LIFE (II)

In present paper, a non-classical method of obtaining the decay constant andhalf-life of ^99mTc was introduced. The results were compared with that obtained bythe classical method of the least square analysis. The half-life by non-classioal me-thod is 6.006±0.004 hours, that by classical method is 6.009±0.005 hours.     

无损残余应力测量及其新技术

简述及比较了主要的残余应力无损测量技术，重点为磁力法，并介绍一台新的磁力仪MAPS，且对MAPS及传统磁力仪作了比较，同时以X射线及中子衍射得到的结果验证了MAPS的可靠性，也介绍了文献上较少见的火车钢轨残余应力分布图。     

在18-冠-6存在下苯乙烯无乳化剂乳液聚合

本文研究了在苯乙烯不外加乳化剂的乳液聚合体系中,加入王冠醚18-冠-6对聚合反应及其产物的影响。发现18-冠-6能起到相转移催化作用,并提出两相粒子成核机理,对实验结果作出了合理的解释。     

A simplified liquid chromatography-mass spectrometry assay for artesunate and dihydroartemisinin, its metabolite, in human plasma

Artesunate (AS) is a potent antimalarial that is used worldwide for the treatment of malaria. A simple method with a total run time of 12 min was developed and validated for the quantification of AS and dihydroartemisinin (DHA), its active metabolite, in human (heparinized) plasma based on one-step protein precipitation in acetonitrile using artemisinin (ARN) as an internal standard, followed by liquid chromatography with a single quadrupole mass spectrometry system connected to a C18 column. Peak area ratio responses were fitted to the 2nd-order curve type, polynomial equation with weighting (1/concentration) over a quantification range between 3.20/5.33-3,000/5,000 nM (1.23/1.52-1153/1422 ng/mL) of AS/DHA showing linearity with very good correlation (r2>0.999). Single ion recordings of 5 μL injections of plasma extracts allowed for limits of detection of 1.02 nM (0.39 ng/mL) for AS and 0.44 nM (0.13 ng/mL) for DHA. The inter-assay and intra-assay accuracy and precision of the method was very good with an inaccuracy of ±12.4% and coefficients of variation of ≤10.7% at all tested concentrations. The recovery of the analytes from plasma was ≥95%. Other commonly used antimalarials including mefloquine, quinine, and chloroquine, did not interfere with the analysis. Post-preparative tests over 24 h in an autosampler (10 °C) showed that the DHA response was only 2.1% of AS from auto-hydrolysis, and β-DHA was the major, stable epimer that was used for quantification of DHA. In contrast, α-DHA increased steadily up to 600%. Artesunate and DHA in plasma were stable through three freeze/thaw cycles for up to 6 h at room temperature and up to one year at -80 °C.