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排序方式: 共有128条查询结果,搜索用时 15 毫秒
1.
Yogesh K. Vohra Gopi K. Samudrala Samuel L. Moore Jeffrey M. Montgomery Georgiy M. Tsoi Nenad Velisavljevic 《高压研究》2015,35(3):282-288
Ultra-high static pressures have been achieved in the laboratory using a two-stage micro-ball nanodiamond anvils as well as a two-stage micro-paired diamond anvils machined using a focused ion-beam system. The two-stage diamond anvils’ designs implemented thus far suffer from a limitation of one diamond anvil sliding past another anvil at extreme conditions. We describe a new method of fabricating two-stage diamond micro-anvils using a tungsten mask on a standard diamond anvil followed by microwave plasma chemical vapor deposition (CVD) homoepitaxial diamond growth. A prototype two-stage diamond anvil with 300?µm culet and with a CVD diamond second stage of 50?µm in diameter was fabricated. We have carried out preliminary high pressure X-ray diffraction studies on a sample of rare-earth metal lutetium sample with a copper pressure standard to 86?GPa. The micro-anvil grown by CVD remained intact during indentation of gasket as well as on decompression from the highest pressure of 86?GPa. 相似文献
2.
Propagation of an electromagnetic soliton in an anisotropic biquadratic ferromagnetic medium 下载免费PDF全文
Information storage technology based on anisotropic ferromagnets with sufficiently high magneto-optical effects has received much attention in recent years.Magneto-optical recording combines the merits of magnetic and optical techniques.We investigate the magneto-optical effects on a biquadratic ferromagnet and show that the dynamics of the system are governed by a perturbed nonlinear Schro¨dinger equation.The evolutions of amplitude and velocity of the soliton are found to be time independent,thereby admitting the lossless propagation of the electromagnetic soliton in the medium,which may have potential applications in soliton based optical communication systems.We also exploit the role of perturbation,which has a significant impact on the propagation of an electromagnetic soliton. 相似文献
3.
Three-dimensional quantitative structure–activity relationship (3D-QSAR) models were developed based on comparative molecular
field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA), on a series of 43 hydroxyethylamine
derivatives, acting as potent inhibitors of β-site amyloid precursor protein (APP) cleavage enzyme (BACE-1). The crystal structure of the BACE-1 enzyme (PDB ID: 2HM1)
with one of the most active compound 28 was available, and we assumed it to be the bioactive conformation of the studied series, for 3D-QSAR analysis. Statistically
significant 3D-QSAR model was established on a training set of 34 compounds, which were validated by a test set of 9 compounds.
For the best CoMFA model, the statistics are, r
2 = 0.998, r2cv = 0.810{r^{2}_{\rm cv} = 0.810} , n = 34 for the training set and r2pred = 0.934{r^{2}_{\rm pred} = 0.934} , n = 9 for the test set. For the best CoMSIA model (combined steric, electrostatic, hydrophobic, and hydrogen bond donor fields),
the statistics are r
2 = 0.978, r2cv = 0.754{r^{2}_{\rm cv} = 0.754} , n = 34 for the training set and r2pred = 0.750{r^{2}_{\rm pred} = 0.750} , n = 9 for the test set. The resulting contour maps, produced by the best CoMFA and CoMSIA models, were used to identify the
structural features relevant to the biological activity in this series of analogs. The data generated from the present study
will further help to design novel, potent, and selective BACE-1 inhibitors. 相似文献
4.
Jaleel CA Manivannan P Kishorekumar A Sankar B Gopi R Somasundaram R Panneerselvam R 《Colloids and surfaces. B, Biointerfaces》2007,59(2):150-157
Catharanthus roseus (L.) G. Don plants were grown in different water regimes in order to study the drought induced osmotic stress and proline (PRO) metabolism, antioxidative enzyme activities and indole alkaloid accumulation. The plants under pot culture were subjected to 10, 15 and 20 days interval drought (DID) stress from 30 days after sowing (DAS) and regular irrigation was kept as control. The plants were uprooted on 41 DAS (10 DID), 46 DAS (15 DID) and 51 DAS (20 DID). The drought stressed plants showed increased aminoacid (AA), glycine betaine (GB) and PRO contents and decreased proline oxidase (PROX) and increased γ-glutamyl kinase (γ-GK) activities when compared to control. The antioxidative enzymes like peroxidase (POX) and polyphenol oxidase (PPO) increased to a significant level in drought stressed plants when compared to control. The drought stressed C. roseus plants showed an increase in total indole alkaloid content in shoots and roots when compared to well-watered control plants. Our results suggest that the cultivation of medicinal plants like C. roseus in water deficit areas would increase its PRO metabolism, osmoregulation, defense system and the level of active principles. 相似文献
5.
A novel, ultrafast, mild and scalable amide bond formation strategy in methanol using simple thioacids and amines is described. The mechanism suggests that the coupling reactions are initially mediated by CuSO(4)·5H(2)O and subsequently catalyzed by in situ generated copper sulfide. The pure peptides were isolated in satisfactory yields in less than 5 minutes. 相似文献
6.
An environmentally benign [Cu(I)]-catalyzed oxidation of activated (benzylic/allylic) alcohols to the corresponding carbonyl compounds is presented. Interestingly, the reaction was also compatible with benzylic alcohols containing ortho-bromo substituents on the aromatic ring without competing with the expected intermolecular Buchwald coupling. Significantly, the catalytic system enables the synthesis of cinnamate-esters in a sequential domino one-pot fashion via oxidation followed by Wittig–Horner protocol. 相似文献
7.
Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol 总被引:4,自引:0,他引:4
Devaraj GN Parakh SR Devraj R Apte SS Rao BR Rambhau D 《Journal of colloid and interface science》2002,251(2):360-365
Monomers of some amphiphiles organize into bilayers to form liposomes and niosomes. Such bilayers are unstable or leaky and hence cholesterol is a common ingredient included to stabilize them. Cholesterol stabilizes bilayers, prevents leakiness, and retards permeation of solutes enclosed in the aqueous core of these vesicles. Other than cholesterol a material with good bilayer-stabilizing properties is yet to be identified. We have substituted cholesterol with fatty alcohols in niosomes containing polyglyceryl-3-di-isostearate (PGDS) and polysorbate-80 (PS-80) to explore their membrane-stabilizing property via permeation studies. Niosomes of polyglyceryl-3-di-isostearate, fatty alcohol/cholesterol, and polysorbate were prepared by ether injection method. Aqueous solution of ketorolac tromethamine (KT) was entrapped in them. The effects of alkyl chain length of fatty alcohols (C(12), C(14), C(16), C(18), and C(16+18)), of acyl chain length of polyoxyethylene sorbitan monoester surfactants, and of the molar ratio of lipid mixture on the release rate of ketorolac from niosomes were assessed by employing modified dissolution-dialysis method. Niosomes with cholesterol or fatty alcohols have exhibited a common release pattern. Niosomes containing fatty alcohol showed a considerably slower release rate of KT than those containing cholesterol. Based on the release rate, fatty alcohols can be ranked as stearyl相似文献
8.
9.
Numerous products (such as paints, inks, foods, and beverages) and processes (such as coating, coagulation, sedimentation, lubrication, and paper-making) depend on the stability of the liquid films separating the dispersed phase from the continuous phase in the presence of nanoparticles or surfactant micelles. Nanoparticles exhibit a tendency to form ordered layers (i.e., stratification) and particle in-layer structures in these thin films at a sufficiently high concentration, resulting in a structural force that stabilizes the dispersion. The dispersion stability depends on the film size and the nanoparticle concentration. 相似文献
10.
Richard H. Fertel Gopi A. Tejwani Christine R. Albrightson Ronald W. Hart† 《Photochemistry and photobiology》1981,34(2):275-278
Abstract— The concentrations of cyclic AMP and cyclic GMP in human skin fibroblasts in culture were determined after exposing the cells to varying fluences of UV (254 nm) light. The cyclic nucleotide concentrations of cells irradiated in the log phase of growth were unchanged relative to controls. In contrast, there was a rise in the concentration of cyclic AMP in cells irradiated after they reached confluency. The increase in concentration was observed as early as 30 min after irradiation, reached a maximum of about 200% of control at 4 to 6 h after exposure, and returned to control values by 24 h after irradiation. The effect was proportional to a UV fluence from 5 to 20 J/m2 , and was blocked by the addition of the UV absorbing agent para-aminobenzoic acid. In contrast, our results indicated that UV light had no effect on the concentration of cyclic GMP in human fibroblast cell cultures. Because of the importance of cyclic nucleotides in the regulation of cellular function, it is reasonable to hypothesize that changes in cyclic AMP induced by UV light may affect the extranuclear functions of irradiated cells. 相似文献