排序方式: 共有50条查询结果,搜索用时 31 毫秒
1.
G. Hirankumar S. Selvasekarapandian M. S. Bhuvaneswari R. Baskaran M. Vijayakumar 《Journal of Solid State Electrochemistry》2006,10(4):193-197
Thick films of pure polyvinyl alcohol and polyvinyl alcohol doped with silver nitrate with different compositions have been
prepared by solution cast technique. The FT-IR spectrum confirms the complexation process. The conductivity of the pure polyvinyl
alcohol is of the order of 10−7 Sm−1 at 90 °C, and its value increases by two orders of magnitude when doped with 20 wt% of AgNO3. The activation energy, calculated from the Arrhenius plot for all compositions of the poly vinyl alcohol doped with silver
nitrate, is between 0.24 and 0.35 eV. The migration energy for the ion in polymer electrolyte has been calculated from the
modulus spectrum, and is in good agreement with the activation energy calculated from the Arrhenius plot. The modulus spectra
indicate the non-Debye nature of the material. 相似文献
2.
We have synthesized a new series of azo‐bis antipyrine derivatives from a one‐pot multicomponent Knoevenagel/Michael addition reaction of antipyrine, with a diversity of azo aldehydes in ethanol and L‐Proline as a catalyst under reflux condition. The anti‐inflammatory activity of the final products was assessed using the inhibition of albumin denaturation technique. Compound 3f showed an inhibitory effect with IC50 values of 3.6 μM with respect to the standard anti‐inflammatory drug Aspirin, with IC50 values of 2 μM. In addition, molecular docking was performed to confirm the in vitro results against the enzymatic inhibition activity of COX‐2 enzymes in which compound 3f showed good binding affinity with an inhibition constant (Ki) of 1.79 nM. 相似文献
3.
We have described a simple, convenient, and high-yielding one-pot synthesis of novel azo chromene derivatives via a three-component reaction of various azo aldehydes with dimedone and malononitrile using 10 mol% of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as catalyst and ethanol as solvent at reflux condition. All the synthesized compounds have been characterized using Fourier-transform infrared spectroscopy (FT-IR), 1H NMR, 13C NMR, and HR-MS spectra and molecular docking was performed to explore new inhibitors of human placental aromatase cytochrome P450 and cyclooxygenase-2 enzymes. Of all the compounds docked, compound (E)-2-amino-4-(4,4-dimethyl-2,6-dioxocyclohexyl)-6-((3-methoxyphenyl)diazenyl-4H-chromene-3-carbonitrile ( 4o ) showed good binding affinity with the active site of human placental aromatase cytochrome P450 enzyme (PDB: 3EQM) with inhibition constant (Ki) 1.66 nM and compound 4o also showed good binding affinity with the active site of cyclooxygenase-2 enzyme (PDB: 6COX) with inhibition constant (Ki) 367.17 pM. In vitro anti-cancer activity studies against MCF-7 cells were also performed for compounds 4o , anastrozole and celecoxib. Compound 4o showed an effective cytotoxicity at 19.8 μg/ml compared to anastrozole and celecoxib (24.7 and 26.2 μg/ml). 相似文献
4.
Kiranmayee Rao Bhuvaneswari Ch Lakshmi M. Narasu Archana Giri 《Applied biochemistry and biotechnology》2010,162(3):871-884
Methanol, acetone and diethyl ether extracts of Alpinia galanga have been evaluated against pathogens viz. Bacillus subtilis MTCC 2391, Enterobacter aerogene, Enterobacter cloacae, Enterococcus faecalis, Escherichia coli MTCC 1563, Klebsiella pneumoniae, Pseudomonas aeruginosa MTCC 6642, Salmonella typhimurium, Staphylococcus aureus and Streptococcus epidermis using Agar well diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of
all the extracts were determined using the macrodilution method. Methanol extracts have shown excellent activity towards all
the pathogens with MIC and MBC values ranging from 0.04–1.28 mg/ml and 0.08–2.56 mg/ml, respectively. The GC–MS analysis of
methanol extracts have yielded compounds like 5-hydroxymethyl furfural (59.9%), benzyl alcohol (57.6%), 1,8 cineole (15.65%),
methylcinnamate (9.4%), 3-phenyl-2-butanone (8.5%) and 1,2 benzenedicarboxylic acid (8.9%), which could be responsible for
its broad spectrum activity. So, A. galanga can be quite resourceful for the development of new generation drugs. 相似文献
5.
Quantum dot capped magnetite nanorings as high performance nanoprobe for multiphoton fluorescence and magnetic resonance imaging 总被引:1,自引:0,他引:1
Fan HM Olivo M Shuter B Yi JB Bhuvaneswari R Tan HR Xing GC Ng CT Liu L Lucky SS Bay BH Ding J 《Journal of the American Chemical Society》2010,132(42):14803-14811
In the present study, quantum dot (QD) capped magnetite nanorings (NRs) with a high luminescence and magnetic vortex core have been successfully developed as a new class of magnetic-fluorescent nanoprobe. Through electrostatic interaction, cationic polyethylenimine (PEI) capped QD have been firmly graft into negatively charged magnetite NRs modified with citric acid on the surface. The obtained biocompatible multicolor QD capped magnetite NRs exhibit a much stronger magnetic resonance (MR) T2* effect where the r2* relaxivity and r2*/r1 ratio are 4 times and 110 times respectively larger than those of a commercial superparamagnetic iron oxide. The multiphoton fluorescence imaging and cell uptake of QD capped magnetite NRs are also demonstrated using MGH bladder cancer cells. In particular, these QD capped magnetite NRs can escape from endosomes and be released into the cytoplasm. The obtained results from these exploratory experiments suggest that the cell-penetrating QD capped magnetite NRs could be an excellent dual-modality nanoprobe for intracellular imaging and therapeutic applications. This work has shown great potential of the magnetic vortex core based multifunctional nanoparticle as a high performance nanoprobe for biomedical applications. 相似文献
6.
Masilamani Jeganmohan Dr. Sivakolundu Bhuvaneswari Dr. Chien‐Hong Cheng Prof. Dr. 《化学:亚洲杂志》2010,5(1):153-159
The reaction of benzynes with N‐heteroaromatics including quinolines, isoquinolines, and pyridines and various terminal alkynes or ketones with an α‐hydrogen in the presence of KF and 18‐crown‐6 in THF at room temperature for 8 h gave various N‐arylated 1,2‐dihydroheteroaromatics in good to moderate yields. Some of these product structures are found in various naturally occurring and biologically active heterocyclic compounds. The reaction involves an unusual multiple construction of new C? C, C? N, and C? H bonds and the cleavage of a C? H bond in one pot. It is likely that the three‐component coupling proceeds through the nucleophilic addition of quinoline to benzyne, which generates a zwitterionic species. The latter then attracts a proton from terminal alkyne (or ketone) to generate an N‐arylated quinolinium cation and an acetylide anion. Further reaction of these two ions provides the final substituted 1,2‐dihydroquinolines. In the reaction, the terminal alkyne acts first as a proton donor and then as a nucleophile. The application of a three‐component coupling reaction product, 1,2‐dihydro‐2‐pyridinyl alkyne in a stereospecific [4+2] Diels–Alder cycloaddition reaction with N‐phenyl maleimide to give an isoquinuclidine derivative, an important core present in various natural products, is demonstrated. 相似文献
7.
Rao K Chodisetti B Gandi S Mangamoori LN Giri A 《Applied biochemistry and biotechnology》2011,165(5-6):1366-1378
Alpinia galanga is a rhizomatous herb rich in essential oils and various other significant phytoconstituents. Rapid direct regeneration was obtained from the rhizome explants (15.66 ± 0.57 shoots) on MS media supplemented with zeatin at a concentration of 2 mg/l. The callus cultures of A. galanga were initiated from the rhizome explants on MS media supplemented with 2 mg/l each of BAP, 2,4-D, and NAA. The callus was analyzed for the presence of a vital phytoconstituent--acetoxychavicol acetate (ACA) associated with various biological properties. ACA was detected in the young friable callus as well as the stationary phase callus. Moreover, the induction of morphogenetic response in callus resulted in higher accumulation of ACA. The phytohormone withdrawal from the propagation media and the subsequent transfer of callus to BAP (2 mg/l) containing MS media has resulted in multiple shoot induction. The regenerated (indirect) plants have shown 1.6-fold higher ACA content (1.253%) when compared to the control plant (0.783%). Micropropagation of such conventionally propagated plants is very essential to meet the commercial demand as well as to ensure easy storage and transportation of disease free stocks. 相似文献
8.
Numerical study on magneto-convection of cold water in an open cavity with variable fluid properties
S. Sivasankaran M. Bhuvaneswari Y.J. Kim C.J. Ho K.L. Pan 《International Journal of Heat and Fluid Flow》2011,32(5):932-942
The aim of the present study is to understand the problem of buoyancy and thermocapillary induced convection of cold water near its density maximum in an open cavity with temperature dependent properties in the presence of uniform external magnetic field. The governing equations are solved by the finite volume method. The results are discussed for various values of reference temperature parameter, density inversion parameter, Rayleigh, Hartmann and Marangoni numbers. It is observed that the temperature of maximum density leaves strong effects on fluid flow and heat transfer due to the formation of bi-cellular structure. Convection heat transfer is enhanced by thermocapillary force when buoyancy force is weakened. 相似文献
9.
The polymer electrolytes composed of a blend of poly (vinyl acetate) (PVAc) and poly (methylmethacrylate) (PMMA) as a host
polymer and LiClO4 as a salt are prepared by a solution casting technique. The formation of blend polymer- salt complex has been confirmed by
FT-IR spectral studies. The conductivity- temperature plots are found to follow an Arrhenius nature. Arrhenius plot shows
the decrease in activation energy with the increase in salt concentration. The dielectric behaviour of the sample is analysed
using dielectric permittivity (ε′), dielectric loss (ε″) and electric modulus (M″) of the samples. The impedance cole- cole
plot shows the high frequency semi- circle is due to the bulk effect of the material and the depression in the semicircle
shows the non-Debye nature of the material. The bulk conductivity is found to vary between 2.5×10−5 Scm−1 to 1.7×10−3 Scm−1 with the increase of salt concentration of blend polymer samples. The migration energy derived from the dissipation factor
is almost equal to the activation energy calculated from conductivity. The modulus spectrum of the samples shows the non-Debye
behaviour of the polymer electrolyte films. The low frequency dispersion of the dielectric constant implies the space charge
effects arising from the electrodes.
Paper presented at the 2nd International Conference on Ionic Devices, Anna University, Chennai, India, Nov. 28–30, 2003. 相似文献
10.
In recent days, humans are easily exposed to many work-related health issues. N-nitrosodiethylamine (NDE), which is considered to be a harmful carcinogenic agent released from rubber-based industries imparts a long-lasting effect on human health and immunity system. The current research investigates the ability of the two-dimensional nanomaterial, blue phosphorene nanosheet (BPNS) to detect the presence of NDE in the environment. Besides, the electronic and structural characteristics of BPNS are initially explored and NDE target vapour is permitted to interact with the chief component, BPNS. We have also designed blue phosphorene device to study the adsorption properties of NDE vapours based on current–voltage characteristics. The adsorption attributes are accounted for the target vapour adsorbed chief component, the results suggest that BPNS can be employed in detecting NDE vapours. 相似文献