Synthesis and properties of low-molecular-weight copolymers of acrylamide with 2-acrylamido-2-methylpropanesulfonic acid,as potential drug carriers

Nontoxic water-soluble low-molecular-weight (MW 14 000–36 000 Da) copolymers of acrylamide with 2-acrylamido-2-methylpropanesulfonic acid, containing from 17.3 to 37.6 mol % sulfonate-containing monomeric units, were synthesized by heterophase radical polymerization in isopropanol or ethanol at 50°C with azobis(isobutyronitrile) as an initiator. Original Russian Text M.V. Solovskii, M.Yu. Eropkin, E.M. Eropkina, A.V. Slita, M.Yu. Smirnova, E.N. Vlasova, E.B. Tarabukina, A.I. Amirova, 2007, published in Zhurnal Prikladnoi Khimii, 2007, Vol. 80, No. 10, pp. 1674–1678.     

Molecular and associative properties of <Emphasis Type="Italic">N</Emphasis>-vinylpyrrolidone copolymers with <Emphasis Type="Italic">N</Emphasis>-crotonoylaminocaproic acid in dilute solutions

The random copolymers of N-vinylpyrrolidone and N-crotonoylaminocaproic acid attractive for the modification of drugs are studied by static and dynamic light scattering, viscometry, and sedimentation-diffusion analysis. The content of functional groups in the copolymers is 14.1–27.0 mol %. Analysis is performed in 0.1 N aqueous solutions of sodium acetate and dimethylformamide. The molecular characteristics of the copolymers with various composition are determined. It is shown that supramolecular structures are present in copolymer solutions and their amount depends on copolymer composition; the effect of solvent on the formation of these structures is ascertained.     

Water-Soluble Luminescent Lanthanide Complexes Based on 2-Methacryloyloxyethyleniminodiacetic Acid Copolymers

Doklady Chemistry - 2-Methacryloyloxyethyleniminodiacetic acid and its new water-soluble copolymers with N-vinylpyrrolidone have been synthesized. The interaction of the copolymers in dilute...     

Synthesis and Properties of Soluble Copolymers of <Emphasis Type="Italic">N</Emphasis>-Vinyl-2-pyrrolidone with 2-Hydroxyethyl Methacrylate

Features of radical copolymerization of N-vinyl-2-pyrrolidone with 2-hydroxyethyl methacrylate in the presence of azobis(isobutyronitrile) were studied. The copolymerization constants of these monomers were calculated. The structure of the resulting copolymer was confirmed. The composition, microstructure, and molecular-weight parameters of the copolymers were determined.__________Translated from Zhurnal Prikladnoi Khimii, Vol. 78, No. 4, 2005, pp. 642–646.Original Russian Text Copyright © 2005 by Solovskii, Tarabukina, Shpyrkov, Denisov, Vlasova, Korchagin.     

Synthesis of Water-Soluble Chemodegradable N-Vinylpyrrolidone-Crotonic Acid-2-Hydroxyethyl Methacrylate Terpolymers Containing Interchain Urethane Cross-Links,as Carriers of Substances with Antimicrobial Activity

Water-soluble branched N-vinylpyrrolidone-crotonic acid-2-hydroxyethyl methacrylate terpolymers containing labile interchain urethane cross-links were prepared. Their molecular-weight characteristics were determined, and the hydrolytic stability under conditions close to those in a living body was evaluated. Polymeric salts of gentamicin were prepared from linear and branched chemodegradable N-vinylpyrrolidone terpolymers.     

Synthesis of Water-Soluble Chemically Degradable Polymers from Glutaraldehyde and N-Vinylpyrrolidone-Allylamine Copolymers

Water-soluble chemically degradable copolymers of N-vinylpyrrolidone with allylamine, containing azomethine links between the polymeric chains, were prepared. The composition and molecular-weight characteristics of the polymers were determined.     

Synthesis of modified N-vinylpyrrolidone-crotonic acid-p-nitrophenyl crotonate terpolymer

Aminolysis of N-vinylpyrrolidone-crotonic acid-p-nitrophenyl crotonate terpolymers with 2-hydroxyethylamine and 3-hydroxypropylamine in dimethyl sulfoxide at 25°C was studied by UV spectroscopy. The factors affecting the aminolysis kinetics were determined. Preparative synthesis of the aminolysis products in dimethyl sulfoxide was performed and the composition of the aminolysis products was determined.     

Complexation of anionic copolymers of acrylamide and N-(2-hydroxypropyl)methacrylamide with aminoglycoside antibiotics

The complexation of aminoglycoside antibiotics neomycin, gentamicin, kanamycin, and amikacin in the form of free bases with carboxyl- and sulfo-containing copolymers of acrylamide and N-(2-hydroxypropyl)methacrylamide (HPMA) in water and water-salt solutions is studied by means of viscometry, equilibrium dialysis, potentiometric titration, and molecular hydrodynamics. Factors influencing the stability of formed copolymer-antibiotic complexes and determinations of their toxicity are established.