排序方式: 共有55条查询结果,搜索用时 171 毫秒
1.
Using CD data (solution, solid state, various temperatures), X-ray data and MO calculations for a number of substituted mandelic acids (phenylglycolic acids) an attempt was made to explain the different results for the relation between sign of the 1Lb CD band and substitution pattern as described in the literature for various types of aromatic compounds. Moreover the reported sector rule has been reconsidered taking into account the sign and magnitude of the spectroscopic moments. It has been found that in any explanation of the signs of the 1Lb CD bands of substituted aromatic compounds both the conformational behaviour and the spectroscopic moments should be taken into account. 相似文献
2.
Fujita M Nakao Y Matsunaga S Seiki M Itoh Y Yamashita J Van Soest RW Fusetani N 《Journal of the American Chemical Society》2003,125(51):15700-15701
A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine. 相似文献
3.
Matsunaga S Kobayashi H van Soest RW Fusetani N 《The Journal of organic chemistry》2005,70(5):1893-1896
Three new bromotyrosine derivatives, 11-N-methylmoloka'iamine (1), 11-N-cyano-11-N-methylmoloka'iamine (2), and kuchinoenamine (3), were isolated as antibacterial constituents from a marine sponge Hexadella sp. Their structures were elucidated on the basis of spectral and chemical methods. They exhibited moderate antibacterial activity against the fish pathogenic bacterium Aeromonas hydrophila. 相似文献
4.
Two new uncommon nitrogenous sesquiterpenes, 11‐ethoxy‐3‐formamidotheonellin ( 1 ) and 7‐ethoxy‐3‐formamidobisabolane‐8,10‐diene ( 2 ), together with two known related sesquiterpenes, 3‐formamidotheonellin (=theonellin formamide; 3 ) and theonellin isothiocyanate ( 4 ), were isolated from the Hainan sponge Axinyssa aff. variabilis. Their structures were determined on the basis of extensive spectroscopic analysis and by comparison of their NMR data with those of known compounds. 相似文献
5.
Linington RG Robertson M Gauthier A Finlay BB van Soest R Andersen RJ 《Organic letters》2002,4(23):4089-4092
Extracts of the marine sponge Caminus sphaeroconia showed potent activity in a screen for bacterial type III secretion inhibitors. Bioassay guided fractionation of the extract led to the isolation of the novel antimicrobial glycolipid caminoside A (1). The structure of caminoside A was elucidated by analysis of spectroscopic data and chemical degradation.[structure: see text] 相似文献
6.
7.
Takada K Uehara T Nakao Y Matsunaga S van Soest RW Fusetani N 《Journal of the American Chemical Society》2004,126(1):187-193
Three new alpha-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C(28) fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit alpha-glucosidase with IC(50) values of 48-170 nM. 相似文献
8.
Nishimura S Matsunaga S Shibazaki M Suzuki K Furihata K van Soest RW Fusetani N 《Organic letters》2003,5(13):2255-2257
Massadine, a highly oxygenated alkaloid, was isolated from the marine sponge Stylissa aff. massa as an inhibitor of geranylgeranyltransferase type I (GGTase I). The structure of massadine has been deduced from spectral data. Massidine inhibited GGTase I from Candida albicans with an IC(50) value of 3.9 microM. [structure: see text] 相似文献
9.
Ji‐Zheng Sun Kao‐Shan Chen Hai‐Li Liu Rob vanSoest Yue‐Wei Guo 《Helvetica chimica acta》2010,93(3):517-521
Two new uncommon epoxy‐substituted nitrogenous bisabolene‐type sesquiterpenes, 3‐formamido‐7,8‐epoxy‐α‐bisabolane ( 4 ), 3‐isocyano‐7,8‐epoxy‐α‐bisabolane ( 5 ), together with three known related sesquiterpenes, 1 – 3 , were isolated from the Hainan sponge Axinyssa sp. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison of their NMR data with those of structurally related compounds. 相似文献
10.
Jansen K van der Steen AF van Beusekom HM Oosterhuis JW van Soest G 《Optics letters》2011,36(5):597-599
We demonstrate intravascular photoacoustic imaging of human coronary atherosclerotic plaque. The data was obtained from two fresh human coronary arteries ex vivo, showing different stages of disease. A 1.25?mm diameter intravascular imaging catheter was built, comprising an angle-polished optical fiber adjacent to a 30?MHz ultrasound transducer. Specific photoacoustic imaging of lipid content, a key factor in vulnerable plaques that may lead to myocardial infarction, is achieved by spectroscopic imaging at different wavelengths between 1180 and 1230?nm. Simultaneous imaging with intravascular ultrasound was performed. 相似文献