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Chetan Bhadaliya Bala Krishna Panigrahy Dipanjan Goswami Sovan Maiti Sanjay Jagannath Gurule Arshad H. Khuroo 《Biomedical chromatography : BMC》2022,36(4):e5337
A selective, highly sensitive, precise, and novel bioanalytical method has been developed and validated to quantify sinococuline, an active constituent present in the phytopharmaceutical drug product containing Cocculus hirsutus plant extract, in vivo. Chromatographic separation was achieved on a Luna Omega Polar-C18 bonded analytical column maintained at 45°C. The isocratic mobile phase consisted of methanol and ammonium formate buffer (60:40, v/v) at acidic pH with a low flow rate of 0.250 mL/min. Detection was performed on an API 4000 mass spectrometer using electrospray ionization in positive polarity and multiple reaction monitoring mode to achieve a lower limit of quantification of 1.50 ng/mL. Excellent accuracy and precision were obtained after extracting the analyte from plasma samples using a chemical analogue as an internal standard in the absence of an isotope-labeled compound. The extraction efficacy was evidenced from recovery study, and the analyte was found to be stable in plasma. Validation study demonstrated linearity with coefficient of correlation, r ≥ 0.99, and minimal matrix effect. This bioanalytical method was successfully applied to evaluate pharmacokinetic parameters of sinococuline from a phase I clinical trial of an aqueous extract of C. hirsutus in healthy human volunteers. 相似文献
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Snehasish Panigrahy Jinhu Liang Shashank S. Nagaraja Zhaohong Zuo Gihun Kim Shijun Dong Goutham Kukkadapu William J. Pitz Subith S. Vasu Henry J. Curran 《Proceedings of the Combustion Institute》2021,38(1):479-488
To improve our understanding of the combustion characteristics of propyne, new experimental data for ignition delay times (IDTs), pyrolysis speciation profiles and flame speed measurements are presented in this study. IDTs for propyne ignition were obtained at equivalence ratios of 0.5, 1.0, and 2.0 in ‘air’ at pressures of 10 and 30 bar, over a wide range of temperatures (690–1460 K) using a rapid compression machine and a high-pressure shock tube. Moreover, experiments were performed in a single-pulse shock tube to study propyne pyrolysis at 2 bar pressure and in the temperature range 1000–1600 K. In addition, laminar flame speeds of propyne were studied at an unburned gas temperature of 373 K and at 1 and 2 bar for a range of equivalence ratios. A detailed chemical kinetic model is provided to describe the pyrolytic and combustion characteristics of propyne across this wide-ranging set of experimental data. This new mechanism shows significant improvements in the predictions for the IDTs, fuel pyrolysis and flame speeds for propyne compared to AramcoMech3.0. The improvement in fuel reactivity predictions in the new mechanism is due to the inclusion of the propyne + H?2 reaction system along with ?H radical addition to the triple bonds of propyne and subsequent reactions. 相似文献
3.
R. Neugart E. W. Otten K. Wendt S. Ahmad N. Panigrahy R. W. Dougherty K. C. Mishra T. P. Das J. Andriessen 《Hyperfine Interactions》1990,59(1-4):145-148
Using the relativistic linked cluster many-body perturbation procedure we have obtained the hyperfine field at the nucleus
of the Ra+ ion in the2S1/2 ground state. There is good agreement between the calculated magnetic moment of213Ra and the results of a recent Zeeman measurement by the collinear laser beam technique. Detailed comparison is carried out
between our result and earlier ones. 相似文献
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A. Abd El-Sabor Mohamed Snehasish Panigrahy Amrit Bikram Sahu Gilles Bourque Henry J. Curran 《Proceedings of the Combustion Institute》2021,38(1):365-373
Ignition delay time measurements for multi-component natural gas mixtures were carried out using a rapid compression machine at conditions relevant to gas turbine operation, at equivalence ratios of 0.5–2.0 in ‘air’ in the temperature range 650–1050 K, at pressures of 10–30 bar. Natural gas mixtures comprising C1–C7 n-alkanes with methane as the major component (volume fraction: 0.35–0.98) were considered. A design of experiments was employed to minimize the number of experiments needed to cover the wide range of pressures, temperatures and equivalence ratios. The new experimental data, together with available literature data, were used to develop and assess a comprehensive chemical kinetic model. Replacing 1.875% methane with 1.25% n-hexane and 0.625% n-heptane in a mixture containing C1–C5 components leads to a significant increase in a mixture's reactivity. The mixtures containing heavier hydrocarbons also tend to show a strong negative temperature coefficient and two-stage ignition behavior. Sensitivity analyses of the C1–C7 blends have been performed to highlight the key reactions controlling their ignition behavior. 相似文献
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Paramita Gayen Somnath Jan Dr. Nilkanta Chowdhury Dr. Snehasish Ghosh Monjuri Hembram Dr. Angshuman Bagchi Dr. Rituparna Sinha Roy 《化学:亚洲杂志》2021,16(24):4018-4036
Developing non-immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis, still remains a formidable challenge. Excessive blood loss of accident victims and battalions cause a huge number of deaths worldwide. Patients with inherited bleeding disorders face acute complications during injury and post-surgery. Biologically-inspired peptide-based hemostat can act as a potential therapeutic for handling coagulopathy. Additionally, non-healing wounds for patients having ischemic diseases can cause severe clinical complications. Advancement in stabilized growth-factor-based proangiogenic therapy may offer effective possibilities for the treatment of ischemic pathology. This review will discuss nature-inspired biocompatible stabilized peptide- and protein-based molecular medicines to serve unmet medical challenges for handling traumatic coagulopathy and impaired wound healing. 相似文献
8.
Surya N. Panigrahy R. W. Dougherty T. P. Das J. Andriessen 《Hyperfine Interactions》1990,59(1-4):141-144
The valence, exchange core polarization and correlation contributions to the magnetic hyperfine constants in the ground states
of the lithiumlike ions Be+, B2+, C3+, N4+, O5+, F6+, Ne7+ and Bi80+ are investigated using relativistic many-body perturbation theory. Radiative corrections have also been studied. Comparison
is made with available experimental data and the trends in the various contributions are analyzed. 相似文献
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Design and synthesis of triptycene based fluorescent polymer with pendent triazole: Effect of functionality on host–guest interaction
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Snehasish Mondal Achintya Jana Ranajit Bera Neeladri Das 《Journal of polymer science. Part A, Polymer chemistry》2017,55(22):3725-3735
Fluorescent materials have emerged as one of the promising candidates for chemical sensing due to their high sensitivity towards analytes that are relatively electron deficient such as nitroaromatics (NACs). Herein, four new 1,2,3‐triazole functionalized dibromo monomers ( 2‐5 ) have been synthesized. These dibromo monomers ( 2‐5 ) have been subsequently polymerized with 2,6‐diethynyltriptycene ( DET ) to yield four new ethynyl linked polymers ( P2‐P5 ) with 1,2,3‐triazole pendent. These polymers are organosoluble, amorphous in nature and have high thermal stability [Td > 289 °C and high char yield (>73%) at 800 °C]. Interestingly these new polymers ( P2‐P5 ) are highly fluorescent in solution (Φ = 0.37–0.43 in DCM) relative to the polymer ( P1 ) that does not have the 1,2,3‐triazole motif as a pendent. The host–guest interaction between these polymers ( P1‐P5 ) and electron deficient molecules (PA and C60) has been investigated. The Stern–Volmer quenching constant (KSV) data suggest that the interaction of picric acid and polymers increases significantly in presence of 1,2,3‐triazole linked pendent group whereas in case of C60, the KSV value decrease considerably in presence of 1,2,3‐triazole linked pendent. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55, 3725–3735 相似文献
10.
Snehasish Bose Sk Monowar Hossein Kallol Paul 《Journal of Fixed Point Theory and Applications》2016,18(3):627-643
Using fixed point theory, we present a sufficient condition for the existence of a positive definite solution of the nonlinear matrix equation \({X = Q \pm \sum^{m}_{i=1}{A_{i}}^*F(X)A_{i}}\), where Q is a positive definite matrix, A i ’s are arbitrary n × n matrices and F is a monotone map from the set of positive definite matrices to itself. We show that the presented condition is weaker than that presented by Ran and Reurings [Proc. Amer. Math. Soc. 132 (2004), 1435–1443]. In order to do so, we establish some fixed point theorems for mappings satisfying (\({\psi, \phi}\))-weak contractivity conditions in partially ordered G-metric spaces, which generalize some existing results related to (\({\psi, \phi}\))-weak contractions in partially ordered metric spaces as well as in G-metric spaces for a given function f. We conclude, by presenting an example, that our fixed point theorem cannot be obtained from any existing fixed point theorem using the process of Jleli and Samet [Fixed Point Theory Appl. 2012 (2012), Article ID 210]. 相似文献