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1.
The interaction of the synthetic oligonucleotide d(C-G-C-G-A-A-T-T-C-G-C-G)2 with two different transition-metal ions has been investigated in aqueous solution by means of 1H NMR spectroscopy. The effects on the DNA due to the presence of manganese(II) or zinc(II) have been monitored by observing the paramagnetic broadening and diamagnetic shifts of the non-exchangeable proton resonance lines, respectively. The 1H NMR spectra acquired during the course of the manganese(II) titration show very distinct broadening effects on certain DNA resonance lines. Primarily, the H8 resonance of G4 is affected, but also the H5 and H6 resonances of C3 are clearly affected by the metal. The results imply that the binding of manganese(II) to DNA is sequence specific. The 1H spectra obtained during the zinc(II) titration reveal diamagnetic shift effects which largely conform with the paramagnetic broadening effects due to the presence of manganese(II), although this picture is somewhat more complex. The H8 resonance of G4 displays a clearly visible high-field shift, while for the other guanosine H8 protons this effect is absent. The H1' and H2' protons of C3 show an effect of similar strength, although in the opposite direction, while H5 and H6 of C3 are only slightly affected. Local differences in the structure of the DNA and the basicities of potential binding sites on different base steps in the sequence might account for the observed sequence selectivity. 相似文献
2.
T.R. Saitoh N. Hashimoto G. Sletten R.A. Bark S. Törmänen M. Bergström K. Furuno K. Furutaka G.B. Hagemann T. Hayakawa T. Komatsubara A. Maj S. Mitarai M. Oshima J. Sampson T. Shizuma P.G. Varmette 《The European Physical Journal A - Hadrons and Nuclei》1998,3(3):197-199
High-spin states in 181Ta have been studied via the 176Yb(11B,α2n) reaction at 52 MeV using the PEX array and at 57 MeV using the NORDBALL array, with α-particle detection. The previously
known, Kπ=(7/2)+ ground state band and Kπ=(9/2)− band have been extended to spins (29/2)+ and (31/2)−, respectively. Two new one-quasiparticle bands, the Kπ=(5/2)+ band built on the known (5/2)+ isomer and a Kπ=((1/2)−) band have been observed. Two other rotational bands with three-quasiparticle structure, Kπ=(15/2)− and ((19/2)+ with π(7/2)[404]ν2(1/2)[510](9/2)[624] and π(9/2)[514]ν2(1/2)[510](9/2)[624] configurations, respectively, have been newly observed. The half-life of the Kπ=((19/2)+) bandhead which decays to the head of the (15/2)− band has been measured to be 140(36) ns. However, transitions from the ((19/2)+) state to the (15/2)− band have not been observed.
Received: 26 August 1998 相似文献
3.
Liu Y Vinje J Pacifico C Natile G Sletten E 《Journal of the American Chemical Society》2002,124(43):12854-12862
The reactions of the anticancer complex trans-[PtCl2{(E)-HN=C(OMe)Me}2] (trans-EE) with a series of ribo and deoxyribodinucleotides have been studied by HPLC and 2D [1H, 15N] HMQC NMR spectroscopy and compared with those of the inactive trans isomer of cisplatin, trans-[PtCl2(NH3)2] (trans-DDP). Reactions of trans-EE with r(ApG) and d(ApG) take place through solvolysis of the starting substrate and subsequent formation of trans G-N7/monochloro and G-N7/monoaqua adducts. Slowly, the monofunctional adducts evolve to a bifunctional adduct forming an unprecedented and unexpected A-N3/G-N7 platinum cross-link spanning two trans positions. For stereochemical reasons, trans platinum complexes cannot form N7/N7 cross-links between adjacent purines in di- or polynucleotides. For the reverse sequence r(GpA), no chelate structure was formed even after a two-week reaction. The reaction of trans-DDP with r(ApG) produces many more products than the analogous reaction with trans-EE. One of these products was identified as the A-N3/G-N7 trans-chelate. 相似文献
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Theodore Tyrikos-Ergas Eric T. Sletten Jhih-Yi Huang Peter H. Seeberger Martina Delbianco 《Chemical science》2022,13(7):2115
Sulfated glycans are involved in many biological processes, making well-defined sulfated oligosaccharides highly sought molecular probes. These compounds are a considerable synthetic challenge, with each oligosaccharide target requiring specific synthetic protocols and extensive purifications steps. Here, we describe a general on resin approach that simplifies the synthesis of sulfated glycans. The oligosaccharide backbone, obtained by Automated Glycan Assembly (AGA), is subjected to regioselective sulfation and hydrolysis of protecting groups. The protocol is compatible with several monosaccharides and allows for multi-sulfation of linear and branched glycans. Seven diverse, biologically relevant sulfated glycans were prepared in good to excellent overall yield.Well-defined sulfated oligosaccharides are important synthetic targets. We present an on resin approach for the synthesis of sulfated glycans with a broad reaction scope that overcomes previous limitations associated with on resin synthesis. 相似文献
7.
R.-D. Herzberg N. Amzal J.E. Bastin F. Becker P.M.T. Brew P.A. Butler A.J.C. Chewter J.F.C. Cocks O. Dorvaux K. Eskola J. Gerl P.T. Greenlees N.J. Hammond K. Hauschild K. Helariutta F. Heßberger M. Houry A. Hürstel R.D. Humphreys G.D. Jones P.M. Jones R. Julin S. Juutinen H. Kankaanpää H. Kettunen T.L. Khoo W. Korten P. Kuusiniemi Y. Le Coz M. Leino A.P. Leppänen C.J. Lister R. Lucas M. Muikku P. Nieminen R.D. Page T. Page P. Rahkila P. Reiter Ch. Schlegel C. Scholey G. Sletten O. Stezowski Ch. Theisen W.H. Trzaska J. Uusitalo H.J. Wollersheim 《The European Physical Journal A - Hadrons and Nuclei》2002,15(1-2):205-208
In-beam conversion electron spectroscopy experiments have been performed on the transfermium nuclei 253, 254No using the conversion electron spectrometer SACRED in nearly collinear geometry in conjunction with the gas-filled separator
RITU at the University of Jyv?skyl?. The experimental setup is discussed and the spectra are compared to Monte Carlo simulations.
The implications for the ground-state configuration of 253No are discussed.
Received: 21 March 2002 / Accepted: 16 May 2002 / Published online: 31 October 2002
RID="a"
ID="a"e-mail: rdh@ns.ph.liv.ac.uk
RID="b"
ID="b"Present address: GANIL, F-14021 Caen, France.
RID="c"
ID="c"Permanent address: IReS Strasbourg, IN2P3-CNRS, F-67037-Strasbourg, France.
RID="d"
ID="d"Present address: CEA/DIF DCRE/SDE/LDN F-91680 Bruyeres-le-Chatel.
RID="e"
ID="e"Present address: Daresbury Laboratory, Daresbury WA4 4AD, UK.
RID="f"
ID="f"Permanent address: IPN Lyon, IN2P3-CNRS, F-69037 Lyon, France. 相似文献
8.
A quadrupole moment of 37?8+14 b has been deduced for the 40 ps shape isomer in 236Pu. The value has been derived from a measured delayed fission fragment angular distribution with an anisotropy of 1.48 ± 0.15 for the isomeric decays at 30°. The deformation of the second minimum expressed by the axes ratio of a spheroid is found to be 2.0 ± 0.3. 相似文献
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10.
Pattison LK Cullen DM Smith JF Fletcher AM Walker PM El-Masri HM Podolyák Z Wood RJ Scholey C Wheldon C Mukherjee G Balabanski D Djongolov M Dalsgaard T Thisgaard H Sletten G Kondev F Jenkins D Lane GJ Lee IY Macchiavelli AO Frauendorf S Almehed D 《Physical review letters》2003,91(18):182501
Evidence is presented for multiphonon excitations based on a high-spin (25 Planck) intrinsic state in the deformed nucleus 182 Os. Angular momentum generation by this mode competes with collective rotation. The experimental data are compared with tilted-axis cranking calculations, supporting the vibrational interpretation. However, the lower experimental energies provide evidence that more complex interactions of states are playing a role. 相似文献