The Effect of Molecular Architecture of Sulfobutyl Ether β-Cyclodextrin Nanoparticles on Physicochemical Properties of Complexes with Moxifloxacin

A method has been developed for nanoparticles synthesis based on oligomers of sulfobutyl ether β-cyclodextrin (SBE-β-CD) and their structure has been studied by FTIR spectroscopy. The physicochemical properties of “guest?host” inclusion complexes formed by SBE-β-CD and its oligomers with moxifloxacin have been investigated. It has been shown that, as compared with SBE-β-CD, the synthesized oligomers have an increased affinity for moxifloxacin: the dissociation constants for the complexes of monomeric and oligomeric SBE-β-CD are (1.0 ± 0.3) × 10^?4 and nearly 5 × 10^?6 M, respectively. The binding efficiency increases due to the multy-point interaction of a moxifloxacin molecule with functional groups of the oligomeric carrier. SBE-β-CD oligomers are promising carriers for drugs, in particular, fluoroquinolone-based antibacterial agents, and may be used for the development of new compositions with improved solubility, bioavailability, and prolonged drug release.     

Adsorption Properties of Mesoporous Silica Gel with β-Cyclodextrin as a Pore-Forming Agent Relative to Moxifloxacin

A method for the synthesis of mesoporous silica gel using β-cyclodextrin as a pore-forming agent is developed. The physical properties and structure of the obtained adsorbent are studied by Fourier-transform IR spectroscopy and the low-temperature adsorption–desorption of nitrogen (BET) method. The material has an average specific surface area of 435 ± 5 m²/g and an average pore size of 5 ± 0.5 nm. This value of the pore size indicates the formation of complex structures from columnar associates of β-cyclodextrin in the synthesis of the material. The adsorption capacity of the obtained material is 0.2 ± 0.05 mg of 2-hydroxypropyl-β-cyclodextrin per milligram of the adsorbent. The dissociation constant of the complexes of moxifloxacin with β-cyclodextrin inside the pores of silica gel is of the order of 5 × 10^–3 M. The resulting system of SiO₂-β-CD is promising for application in the biomedical chemistry as a carrier of biologically active molecules, particularly as an antibacterial preparation of moxifloxacin.     

Influence of Substituents in β-Cyclodextrin on the Interaction of Levofloxacin–β-Cyclodextrin Complexes with Liposomal Membrane

Colloid Journal - The effect of substituents (polar CH2CH(OH)CH3, hydrophobic CH3, and charged $${{\left( {{\text{C}}{{{\text{H}}}_{{\text{2}}}}} \right)}_{{\text{4}}}}{\text{SO}}_{3}^{ - }$$ ) in...     

Physical and Chemical Properties of the Guest–Host Inclusion Complexes of Cyprofloxacin with β-Cyclodextrin Derivatives

Moscow University Chemistry Bulletin - We study the effect of the nature of the substituent in the β-cyclodextrin derivative on the physicochemical properties of the antibacterial drug...     

A Spectral Approach to Study Interaction between Chitosan Modified with Mannose and Concavalin A for the Creation of Address Delivery Systems of Antituberculosis Drugs

Moscow University Chemistry Bulletin - We present a comprehensive study of the receptor–ligand interaction by spectral methods on the example of Concanavalin A lectin and 5 kDa chitosan...     

A study of the physicochemical properties and structure of moxifloxacin complex with methyl-β-cyclodextrin

The physicochemical properties and structure of moxifloxacin?methyl-β-cyclodextrin complex have been studied by UV spectroscopy, FTIR spectroscopy, and computer simulation. The optimal conditions for the formation of the complex have been determined, and the dissociation constant of the complex in acidic media (K _dis = (5.0 ± 0.3) × 10^–5 М) has been obtained. It has been found that complexation significantly slows down the release of the drug in acidic media. Experimental results are in good agreement with computer simulation data. The following mechanism of complex formation has been proposed: the incorporation of the aromatic fragment of moxifloxacin into the cavity of methyl-β-cyclodextrin is followed by additional stabilization of the complex via multiple hydrophobic interactions and hydrogen bonding.