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Palladium-catalyzed, carbon monoxide-mediated reductive N-heterocyclization of nitro-heteroaromatic compounds having an alkene adjacent to the nitro-group affords bicyclic pyrrolo-fused heteroaromatic molecules. This type of reaction was used to prepare the fused bicyclo[3.3.0] ring-system: thieno[3,2-b]pyrrole, thieno[2,3-b]pyrrole, furo[2,3-b]pyrrole, pyrrolo[3,2-d]thiazole, and pyrrolo[2,3-d]imidazole and the bicyclo[4.3.0] ring-systems: pyrrolo[3,2-b]pyridine, pyrrolo[2,3-b]pyridine, pyrrolo[3,2-c]pyridine, pyrrolo[2,3-c]pyridine, pyrrolo[3,2-c]pyridazine, and pyrrolo[3,2-d]pyrimidine in 32-94% yield.  相似文献   
2.
An inherently regiospecific synthesis of isatins (1H-indole-2,3-diones) starting from 1-halo-2-nitrobenzenes is described. The isatins are formed by an intramolecular palladium-catalyzed annulation of 2-(2-haloethynyl)-1-nitrobenzenes via the formation of 2-haloisatogens.  相似文献   
3.
Zinc-iron alloy electrodeposits are providing higher corrosion resistance to steel components and also having better mechanical properties when compared to zinc deposits. This is due to the unique phase structure of the alloy formed. This study elucidates the phase structure of the electrodeposited alloy, based on the deposition kinetics and morphological characteristics. Deposition of iron was hindered by charge-transfer process, at low current densities. But zinc deposition was prevailed through diffusion control, only at high current densities. The probability of substitution of iron in hcp lattice along c-axis is more, than a-axis. This is because the linear density along c-axis is lower than a-axis. Intermetallic compounds of variable compositions were identified. Compounds such as FeZn16, FeZn13, Fe5Zn78 have dominantly “η” phase structure and FeZn6, Fe5Zn22, Fe2Zn7, Fe5Zn29, Fe3Zn13 have “Γ” phase structure.  相似文献   
4.

Abstract  

Three new transition metal complexes [CuL2Cl2], [NiL2Cl2], and [ZnL2Cl2], where L = Schiff base derived from isatin (1H-indole-2,3-dione) and tyramine (4-(2-aminoethyl)phenol), have been synthesized and characterized spectroscopically. The binding properties of these complexes with calf thymus DNA have been investigated by use of electronic absorption spectroscopy, viscosity measurement, cyclic voltammetry, and molecular docking analysis. Moreover, these complexes have been found to promote the cleavage of pUC19 DNA from the supercoiled form I to the open circular form II in the presence of hydrogen peroxide. The newly synthesized compounds were screened for antibacterial activity and subjected to molecular docking studies for inhibition of the enzyme Staphylococcus aureus sortase-A, which is a novel target for antibacterials.  相似文献   
5.
Few novel 4-aminoantipyrine derived Schiff bases and their metal complexes were synthesized and characterized. Their structural features and other properties were deduced from the elemental analysis, magnetic susceptibility and molar conductivity as well as from mass, IR, UV-vis, (1)H NMR and EPR spectral studies. The binding of the complexes with CT-DNA was analyzed by electronic absorption spectroscopy, viscosity measurement, and cyclic voltammetry. The interaction of the metal complexes with DNA was also studied by molecular modeling with special reference to docking. The experimental and docking results revealed that the complexes have the ability of interaction with DNA of minor groove binding mode. The intrinsic binding constants (K(b)) of the complexes with CT-DNA were found out which show that they are minor groove binders. Gel electrophoresis assay demonstrated the ability of the complexes to cleave the pUC19 DNA in the presence of AH(2) (ascorbic acid). Moreover, the oxidative cleavage studies using distamycin revealed the minor groove binding for the newly synthesized 4-aminoantipyrine derived Schiff bases and their metal complexes. Evaluation of antibacterial activity of the complexes against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis, and Klebsiella pneumoniae exhibited that the complexes have potent biocidal activity than the free ligands.  相似文献   
6.
A novel Schiff base has been designed and synthesized using the bioactive ligand obtained from 4-aminoantipyrine, 3,4-dimethoxybenzaldehyde and 2-aminobenzoic acid. Its Cu(II), Co(II), Ni(II), Zn(II) complexes have also been synthesized in ethanol medium. The structural features have arrived from their elemental analyses, magnetic susceptibility, molar conductance, mass, IR, UV–Vis, 1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2 type. The electronic absorption spectral data of the complexes suggest an octahedral geometry around the central metal ion. The interaction of the complexes with calf thymus (CT) DNA has been studied using absorption spectra, cyclic voltammetric, and viscosity measurement. The metal complexes have been found to promote cleavage of pUC19 DNA from the super coiled form I to the open circular form II. The complexes show enhanced antifungal and antibacterial activities compared with the free ligand.  相似文献   
7.
Structures of NASICON glasses of the general formula AB2(PO4)3, where A = Li, Na or K and B = Fe, Ga, Ti, V or Nb, have been investigated using vibrational (IR and Raman) spectroscopies. Phosphate species appear to establish an equilibrium via a disproportionation reaction involving a dynamical bond-switching mechanism where both charge and bonds are conserved. B ions in the system acquire different coordinations to oxygens. Alkali ions cause absorptions due to cage vibrations. All the observed spectroscopic features are consistent with speciation involving disproportionation reactions.  相似文献   
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10.
A novel tyramine derived Schiff base, 3-4-dimethoxybenzylidene-4-aminoantipyrinyl-4-aminoethylphenol(L) and a series of its transition metal complexes of the type, ML2Cl2 where, M=Cu(II), Ni(II), Co(II) and Zn(II) have been designed and synthesized. Their structural features and other properties were deduced from the elemental analysis, magnetic susceptibility and molar conductivity as well as from mass, IR, UV-vis, 1H NMR and EPR spectral studies. The binding properties of these complexes with calf thymus DNA (CT-DNA) were investigated using electronic absorption spectroscopy, viscosity measurement, cyclic voltammetry and molecular docking analysis. The results reveal that the metal(II) complexes interact with DNA through minor groove binding. The interaction has also been investigated by gel electrophoresis. Interestingly, it was found that all the complexes could cleave the circular plasmid pUC19 super coiled (SC) DNA efficiently in the presence of AH2 (ascorbic acid). The complexes showed enhanced antifungal and antibacterial activities compared to the free ligand.  相似文献   
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