Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators

[structures: see text] Both (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy-8-(1-decynyl)benzolactam-V8 were designed and synthesized as PKC modulators. Biological assays reveal the (6R)-ligand to be 20-fold more potent than its (6S)-counterpart in binding to PKC alpha.     

Molecular interactions between amine and cyclic ketones at different temperatures

Measurement of densities ρ, viscosities η, and ultrasonic speeds u has been carried out for binary mixtures of N,N-diethylaniline (N,N-DEA) with acetophenone, cyclopentanone, cyclohexanone (CH), and 2-methylcyclohexanone (Me-CH) and their pure liquids at (303.15 and 308.15) K. These experimental data have been used to calculate the excess molar volume V ^E, deviation in ultrasonic velocity ?u, deviation in isentropic compressibility ?κ _s , and deviation in viscosity ?η. The variation of these properties with composition of the mixtures suggests dipole–dipole interactions and charge-transfer complex formation between N,N-diethylaniline and dipolar ketones. The magnitude of the property is found to depend on the chain length of the ketones’ molecule. The viscosity data have been correlated using three equations: Grunberg and Nissan (Nature 164:799–800, 1949), Katti and Chaudhri (J Chem Eng Data 9:442–443, 1964), and Hind et al. (Trans Faraday Soc 56:328–330, 1960). These results have been fitted to the Redlich–Kister polynomial using multiparametric nonlinear regression analysis to estimate the binary coefficients and standard errors.     

Ultrasonic Studies on Molecular Interactions in Binary Mixtures of N-Methyl Aniline with Methyl Isobutylketone, +3-Pentanone, and +Cycloalkanones at 303.15 K

Densities, ρ, viscosities, η, and ultrasonic sound velocities u of pure methyl isobutylketone, diethylketone, cyclopentanone, cyclohexanone, 2-methyl cyclohexanone and those of their binary mixtures with N-methyl aniline were measured at 303.15 K over the entire composition range. These experimental data have been used to calculate the excess volume (V ^E), deviation in ultrasonic sound velocity (?u), isentropic compressibility (κ _s ), intermolecular free length (L _f), excess intermolecular free length ( $ L_{\text{f}}^{\text{E}} $ L f E ), acoustic impedance (Z), excess isentropic compressibility ( $ \kappa_S^{\text{E}} $ κ S E ), deviation in viscosity (?η) and excess Gibbs energy of activation of viscous flow (G ^*E). The viscosity data have been correlated using three equations proposed by Grunberg and Nissan, Katti and Chaudhri, and Hind et al. The excess/deviations have been fitted by Redlich–Kister equation and the results are discussed in terms of molecular interactions present in these mixtures.