排序方式: 共有68条查询结果,搜索用时 616 毫秒
1.
2.
Yi Zheng Ziqing Wang Gabrielle Lui Dborah Hirt Jean‐Marc Treluyer Sihem Benaboud Radia Aboura Ins Gana 《Biomedical chromatography : BMC》2019,33(5)
Levofloxacin, pefloxacin, ciprofloxacin and moxifloxacin are four fluoroquinolones used in the treatment of serious bacterial infections. The antibacterial activity of fluoroquinolones is concentration dependent. Therefore, therapeutic drug monitoring in daily clinical practice is warranted to ensure the therapy's efficacy and prevent bacterial resistance. The purpose of the present study was to develop a method using high‐pressure liquid chromatography with an ultraviolet detector for simultaneous quantification of these four fluoroquinolones in human plasma. A 50 μL aliquot of plasma was precipitated by 200 μL of methanol using gatifloxacin as internal standard. The chromatographic separation was performed on a Kinetex XB‐C18 column using a mobile phase composed of a mixture of orthophosphoric acid 0.4% (v/v), acetonitrile and methanol at a flow rate of 1.2 mL/min. Dual UV wavelength mode was used, with levofloxacin and moxifloxacin monitored at 293 nm, and pefloxacin and ciprofloxacin monitored at 280 nm. The calibration was linear over the ranges of 0.125–25 mg/L for levofloxacin, 0.1–20mg/L for moxifloxacin and 0.05‐10 mg/L for both pefloxacin and ciprofloxacin. Inter‐ and intra‐day trueness and precision were <13% for all the compounds under study. The proposed method was simple, reliable, cost‐effective and suitable for therapeutic drug monitoring or pharmacokinetics studies. 相似文献
3.
Designs, Codes and Cryptography - For a long time, the literature has demonstrated that designs and codes are exciting topics for combinatorics and coding theory. Linear codes and t-designs are, in... 相似文献
4.
Trinitrotoluene, known as TNT, is a widely used powerful explosive. It is a poisonous material, which injures almost all cells, especially those of liver, bone marrow, and kidney. Estrone is a sex hormone having an electron rich aromatic (phenolic) ring that is capable of forming a π complex with molecules containing an electron deficient π system. This study has focused on investigating the tendency of the complex formation of TNT with estrone. It has been thought that the formation of estrone‐TNT π complex might take place in a human body exposed to acute or prolong period of this hazardous chemical and consequently estrone activities might be impaired. The complex formation reaction was investigated mainly using DFT method with B3LYP/6‐31G(d, p) basis set in gas phase. The existence of π interaction between estrone and TNT was demonstrated by computational spectroscopic analyses (UV/Vis, IR, and 1H NMR techniques). The frontier molecular orbital (HOMO and LUMO) analyses have shown that the considered π complex is very resistant to oxidation with respect to its components, estrone and TNT. 相似文献
5.
Using Breit-Wigner resonance relation,bounds on the magnetic moment of the tau-neutrino are calculated through the reaction e+e-→v(v)γ at the neutral boson pole in the framework of a superstringinspired E6 model which has one extra low-energy neutral gauge boson and a LRSM. 相似文献
6.
7.
C. Aydın M. Bayar A.H. Yılmaz 《The European Physical Journal C - Particles and Fields》2006,48(1):111-115
We present a calculation of the coupling constant of f0→ργ and a0→ργ decays from the point of view of the light cone QCD sum rules. We estimate the coupling constants gf0ργ, which are an essential ingredient in the analysis of physical processes involving the isoscalar f0(980) and the isovector a0(980) mesons. PACS 12.38.Lg, 13.40.Hq, 14.40.AqAn erratum to this article can be found at 相似文献
8.
Designs, Codes and Cryptography - According to a magnific method due to I. Tamo and A. Barg, a class of polynomials over finite fields, called good polynomials, was introduced and used to construct... 相似文献
9.
In this study, we investigate two important questions related to dynamic pricing in distribution channels: (i) Are coordinated pricing decisions efficient in a context where prices have carry-over effects on demand? (ii) Should firms practice a skimming or a penetration strategy if they choose to coordinate or to decentralize their activities? To answer these questions, we consider a differential game that takes place in a bilateral monopoly where the past retail prices paid by consumers contribute to the building of a reference price. The latter is used by consumers as a benchmark to evaluate the value of the product, and by firms to decide whether to adopt a skimming or a penetration strategy. 相似文献
10.
Groni S Dorlet P Blain G Bourcier S Guillot R Anxolabéhère-Mallart E 《Inorganic chemistry》2008,47(8):3166-3172
In the present work we report the reactivity of [LMnII]2+ toward addition of hydrogen peroxide (H2O2) in acetonitrile solution, where L is a pentadentate polypyridine ligand. Formation of peroxo complexes is evidenced by low-temperature UV-visible spectroscopy, ESI-mass spectrometry, and EPR spectroscopy using parallel as well as perpendicular mode detection. The influence of the medium (basicity, water content) on the formation of various species is investigated. In basic nonanhydrous medium the fate of the reaction mixture solution is the formation of the di-mu-oxo mixed-valent Mn(III)Mn(IV) dinuclear complex. In acidic medium the building of the oxo bridges is avoided and the reaction mixture evolves toward oxidation of the ligand L. This reaction route offers new opportunities for the study of oxidation reactivity of Mn (hydro)peroxo complexes. 相似文献