Efficient,High-Yield Protocol for the One-Pot Synthesis of Benzopyran Derivatives Catalyzed by p-TSA in Aqueous Media

A short and simple synthesis of benzopyran derivatives was accomplished in good to excellent yields by the reaction of salicylaldehyde with 1,3-cyclohexanediones in aqueous media catalyzed by para-toluenesulfonic acid. The structures were established by spectroscopic data and further confirmed by x-ray analysis. In addition, water was chosen as a green solvent.     

Total synthesis of sapinofuranone A from d-ribose

The total synthesis of sapinofuranone A has been achieved starting from naturally occurring carbohydrate d-ribose via a short and high yielding route. The key transformations include Wittig olefination, Ohira–Bestmann reaction, Sonogashira coupling. Finally acetonide deprotection and subsequent lactonization using catalytic amount of hydrochloric acid completed the total synthesis of sapinofuranone A.