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排序方式: 共有98条查询结果,搜索用时 10 毫秒
1.
Prashant Thakare Abhijit Shinde Sagar Dakhane Abhijit Chavan Vivek D. Bobade Pravin C. Mhaske 《Journal of heterocyclic chemistry》2021,58(9):1867-1877
Cyclocondensation reaction of 4-(2-bromoacetyl)quinolin-1-ium bromide ( 4a–d ) with substituted arylthiourea, ( 5a–g ) afforded 4-(6-substituted quinolin-4-yl)-N-aryl/pyridyl thiazol-2-amine ( 6a-ab ). These newly synthesized derivatives were evaluated for in vitro antibacterial activity against Escherichia coli (NCIM 2574), Proteus mirabilis (NCIM 2388) (Gram-negative strains), Bacillus subtilis (NCIM 2063), Staphylococcus albus (NCIM 2178) (Gram-positive strains) and in vitro antifungal activity against Aspergillus niger (ATCC 504) and Candida albicans (NCIM 3100). Compounds 6a , 6b , 6d , 6f , 6k , and 6l showed moderate to good antibacterial activity against S. albus. Ten derivatives 6c , 6q , 6r , 6s , 6t , 6v , 6w , 6x , 6y , and 6aa , showed moderate to good activity against A. niger. N-[4-(Quinolin-4-yl)-1,3-thiazol-2-yl]pyridin-2-amine presented comparable activity against A. niger with respect to standard drug Rouconazole. 相似文献
2.
Anju Singh Ritushree Kukreti Luciano Saso Shrikant Kukreti 《Molecules (Basel, Switzerland)》2022,27(3)
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the biochemical processes leading to elevated production of reactive oxygen species (ROS) and the antioxidant defense system of the body. It has a ubiquitous role in the development of numerous noncommunicable maladies including cardiovascular diseases, cancers, neurodegenerative diseases, aging and respiratory diseases. Diseases associated with metabolic dysfunction may be influenced by changes in the redox balance. Lately, there has been increasing awareness and evidence that diabetes mellitus (DM), particularly type 2 diabetes, is significantly modulated by oxidative stress. DM is a state of impaired metabolism characterized by hyperglycemia, resulting from defects in insulin secretion or action, or both. ROS such as hydrogen peroxide and the superoxide anion introduce chemical changes virtually in all cellular components, causing deleterious effects on the islets of β-cells, in turn affecting insulin production. Under hyperglycemic conditions, various signaling pathways such as nuclear factor-κβ (NF-κβ) and protein kinase C (PKC) are also activated by ROS. All of these can be linked to a hindrance in insulin signaling pathways, leading to insulin resistance. Hyperglycemia-induced oxidative stress plays a substantial role in complications including diabetic nephropathy. DM patients are more prone to microvascular as well as atherosclerotic macrovascular diseases. This systemic disease affects most countries around the world, owing to population explosion, aging, urbanization, obesity, lifestyle, etc. However, some modulators, with their free radical scavenging properties, can play a prospective role in overcoming the debilitating effects of OS. This review is a modest approach to summarizing the basics and interlinkages of oxidative stress, its modulators and diabetes mellitus. It may add to the understanding of and insight into the pathophysiology of diabetes and the crucial role of antioxidants to weaken the complications and morbidity resulting from this chronic disease. 相似文献
3.
4.
Joshi Shrikant V. Park Jin Y. Taylor P. R. Richardson L. S. 《Plasma Chemistry and Plasma Processing》1985,5(2):143-161
Plasma Chemistry and Plasma Processing - A new integral mean diffusivity is proposed for the calculation of the mass transfer rate around a small particle immersed in a thermal plasma gas.... 相似文献
5.
K. S. Adhav M. V. Dawande R. S. Thakare R. B. Raut 《International Journal of Theoretical Physics》2011,50(2):339-348
Bianchi type-III cosmological model of universe filled with dark energy from a wet dark fluid (WDF) in presence and absence
of magnetic field is investigated in general theory of relativity. We assume that F
12 is the only non-vanishing component of F
ij
. We obtain exact solutions to the field equations using the condition that expansion is proportional to the shear scalar
i.e. (B=C
n
). The physical behavior of the model is discussed with and without magnetic field. We conclude that universe model do not
approach isotropy through the evolution of the universe. 相似文献
6.
Salunkhe Nilesh G. Ladole Chandrashekhar A. Thakare Nikita V. Aswar Anand S. 《Research on Chemical Intermediates》2018,44(1):355-372
Research on Chemical Intermediates - We report the synthesis of sulfuric acid-functionalized silica-coated magnetic nanoparticles (MgFe2O4@SiO2–SO3H) as a catalyst for the microwave-assisted... 相似文献
7.
Syntheses of New Unsymmetrical 2,5‐Disubstituted‐1,3,4‐oxadiazoles and 1,2,4‐Triazolo[3,4‐b]‐1,3,4‐thiadiazoles Bearing Thieno[2,3‐c]pyrazolo Moiety
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Shivaraj P. Patil Shrikant B. Kanawade Dinesh C. Bhavsar Prashant S. Nikam Sachin A. Gangurde Raghunath B. Toche 《Journal of heterocyclic chemistry》2014,51(2):368-373
New series of (thieno[2,3‐c]pyrazolo‐5‐yl)‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazoles 10a , 10b , 10c and (thieno[2,3‐c]pyrazol‐5‐yl)‐1,3,4‐oxadiazol‐3(2H)‐yl)ethanones 6a , 6b , 6c has been synthesized from thieno[2,3‐c]pyrazole‐5‐carbohydrazide 3 by multistep reaction sequence. (5‐Aryl‐1,3,4‐oxadiazol‐2‐yl)‐1H‐thieno[2,3‐c]pyrazoles 4a , 4b , 4c were also synthesized from thieno[2,3‐c]pyrazole‐5‐carbohydrazide 3 by cyclization with various aromatic carboxylic acids. The hydrazide 3 was obtained by reaction of thieno[2,3‐c]pyrazole‐5‐carboxylate 2 with hydrazine hydrate in good yield, and compound 2 was obtained by the reaction of 5‐chloro‐3‐methyl‐1‐phenyl‐1H‐pyrazole‐4‐carbaldehyde 1 and 2‐ethyl thioglycolate in presence of sodium alcoholate in good yield. 相似文献
8.
Sachin A. Gangurde Shrikant B. Kanawade Prashant S. Nikam Dinesh C. Bhavsar Raghunath B. Toche 《Journal of heterocyclic chemistry》2014,51(4):883-890
Synthesis of ethyl 5‐amino‐4‐cyano‐1‐phenyl‐1H‐pyrazole‐3‐carboxylate 5 has been achieved via abnormal Beckmann rearrangement of o‐chloroaldehyde 1 . Reaction of o‐aminocarbonitrile 5 with concentrated H2SO4 furnished expected o‐aminocarboxamide pyrazole 6 . Key intermediates o‐aminocarbonitrile 5 and o‐aminocarboxamide 6 were successfully utilized for the synthesis of pyrazolopyrimidine derivatives. The replacement of Cl in o‐chlorocarbonitrile 3 with secondary amine furnished new synthon 13 , which was further used for the synthesis of polysubstituted heterocycles. The obtained new products were well characterized by IR, 1H and 13C NMR, and mass spectra. 相似文献
9.
Hull-kernel topology on the set ∑(R) of prime ideals of a ring R with unity and without nilpotent elements is discussed. The restriction of this topology to the set π(R) of minimal prime ideals of R has been investigated in detail. The compactness of π(R) has been characterized in several ways. An interesting characterization of Baer rings is given.A functorial correspondence between the category of rings having the property that every prime ideal contains a unique minimal prime ideal and their minimal spectra is established. 相似文献
10.