Indole derivatives. 135. 5-[2-(4-Methoxyphenyl)ethenyl]indolines and indoles

5-[2-(4-Methoxyphenyl)ethenyl]indolines were obtained from 5-formyl-1-methyl- or 5-forrayl-1-benzylindolines by the Witting reaction with 4-methoxybenzylidenetriphenylphosphorane. Their dehydrogenation led to the formation of the corresponding compounds of the indole series. The corresponding hydroxy compounds were obtained by demethylation of the methoxyindole with boron tribromide and were converted into the acetoxy derivatives of indoline and indole.For communication 134, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 911–914, July, 1989.     

Indole derivatives. 124. 5-(2-phenylethenyl)indolines and 5-(2-phenylethenyl)indoles

5-(2-Phenylethenyl)indolines, the dehydrogenation of which leads to the formation of the corresponding compounds of the indole series, were obtained from 5-formyl-1-methyl(or benzyl)indolines via the Grignard reaction with benzyl-magnesium chloride and subsequent dehydration. The hormonal activity of the synthesized compounds was studied.See [1] for communication 123.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No, 4, pp. 466–469, April, 1984.     

Indole derivatives.

Acylation of 1-acylindoles by acetylchloride and chloroacetylchloride in the presence of aluminum chloride leads to formation of 3-acetyl- and 6-chloroacetyl-1-acylindoles, respectively.For Communication 130, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 328–330, March, 1989.     

Indole derivatives

Tris (1-benzyl-5-indolinyl)phosphine oxide, the structure of which was confirmed by alternative synthesis, is formed as a side product along with the previously described dimethyl-1-benzylindoline-5-phosphonate in the reaction of 1-benzyl-5-lithioindoline with dimethyl chlorophosphate. Dimethyl l-benzylindole-5-phosphonate was obtained by the dehydrogenation of dimethyl 1-benzylindoline-5-phosphonate with chloranil. The catalytic dehydrogenation of this same indollne is accompanied by debenzylation, which leads to dimethyl indole-5-phosphonate, and by splitting of the p-C bond.See [1] for communication LXXV.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 498–501, April, 1972.     

Steroids

Chemistry of Natural Compounds - The opening of the epoxide ring of the 3,20-diketal of 16α, 17α-epoxy-Δ5-pregnene-3, 20-dione and of the acetate of the 20-ketal of 16α,...