Crystal growth and spectroscopic properties of Yb:CaYAlO4 single crystal

A Yb³⁺-doped CaYAlO₄ laser crystal has been grown by the Czochralski technique. The segregation coefficient was measured by Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES). The cell parameters were analyzed with X-ray diffraction experiments. Color defects in Yb:CaYAlO₄ have been evidenced to be similar to those in undoped CaYAlO₄. The polarized absorption spectra and the fluorescence spectrum of the Yb:CaYAlO₄ crystal were measured at room temperature. The fluorescence decay time of the Yb³⁺ ion was investigated. The results show that Yb:CaYAlO₄ has potential as a laser gain medium for an ultrashort laser system.     

角钢插入式基础抗拔试验与分析

通过对 １１ 组 １９ 个角钢插入式基础试件的抗拔试验,得到了角钢在不同埋置长度、不同锚固形式下的抗拔承载力、角钢与混凝土间的粘结应力分布、平均粘结应力以及角钢插入式基础的破坏形式、最大试验荷载等。为工程设计提供了基础数据。     

Study of Multiplicity of Hartree-Fock Solutions

By means of a generalized three-level solvable model,the self-consistent procedure for solving the Hartree-Fock(HF) equation is studied in some detail.It is pointed out that due attention must be paid for the multiplicity of solutions.Different criteria for the choice of an adequate solution are considered and discussed.Further,the reason of the sudden jump of the HF solution in certain force-parameter(FP) region,the stability of the HF solution and its dependence on FPs are investigated.     

相对论σ–ω模型中负能海的贡献

在考虑负能海的情况下,运用σ－ω模型,得到了核物质的饱和曲线和好的不可压缩系数,引入形状因子处理了发散积分,仔细研究了ω介子引起的接触相互作用的影响,计算了核基态平均每核子的剩余介子数.     

Facile Syntheses of Novel Salts of a Triazole Antifungal Agent with Enhanced Solubility

Acid addition salts of a triazole antifungal agent itraconazole were prepared with an aim to enhance the aqueous solubility and dissolution characteristics of the drug. Nitric, sulfuric, and p‐toluenesulfonic acid addition salts ( 1a , 1b , 1c ) were prepared using facile synthetic procedures. The solubility of the salts in water was found to be 24, 22, and 58 mg/mL, respectively, for 1a , 1b , and 1c , which is significantly higher than that of itraconazole (1 ng/mL). In addition to this, solubility of the salts in simulated gastric fluid (SGF) and other pharmaceutically used solvents such as ethanol and propylene glycol was also improved to a great extent. Also, it was observed that from 1a , 1b , and 1c , approximately 33, 26, and 45% drug was released in SGF in 3 h, whereas less than 10% drug was released from the free base form.     

Taurine‐Induced Fabrication of Nano‐Architectured Conducting Polypyrrole on Biomedical Titanium

In this article, taurine, one of the small biomolecules associated with bone metabolism, is firstly utilized to induce the fabrication of nano‐architectured conducting polypyrrole (NCPPy) on biomedical titanium in diverse pH values of phosphate buffer solution (PBS). Accordingly, the possible mechanism for the fabrication of NCPPy is proposed, which is dependent on the states of polytaurine from the polymerization of taurine, i.e., the inability of forming polytaurine and unordered restricted space results in taurine‐incorporated and polytaurine‐incorporated tightly packed nanoparticles (pH 6.2 and 8.0), respectively, and however, ordered restricted space constructed by polytaurine chains induces the fabrication of polytaurine‐incorporated nanopillars (pH 6.8) and polytaurine‐incorporated nanowire networks (pH 7.4).

     

Thermal characterization and compatibility studies of itraconazole and excipients for development of solid lipid nanoparticles

The current study was performed to investigate possible interactions between triazole antifungal drug itraconazole (ITR) with selected excipients commonly used for development of solid lipid nanoparticles. The excipients included common lipids (glyceryl behenate (Compritol 888 ATO?), glyceryl monostearate, stearic acid, and cetyl palmitate), charge inducers (dicetyl phosphate and stearlyamine), and surfactants (sodium cholate and sodium deoxycholate). Differential scanning calorimetry, isothermal stress testing, Fourier transform infrared spectral analysis, optical microcopy, and X-ray powder diffraction analysis were performed for assessing the compatibility between the drug and the excipients. Results of the study suggest that the stearic acid exhibited drug–excipient interactions, whereas all other excipients used in the study were found to be compatible with ITR.     

采用多聚酶链反应技术直接从人群基因组DNA筛选HLA-DR4基因

本文建立了一种简易、快速的外周血DNA抽提方法，并用于多聚酶链反应〔PCR)，对HLA-DR,基因进行定型.同时与一些经血清学定型的样品进行比较，结果证实PCR方法更为可靠.对56例上海地区随机正常人DNA样品进行PCR定型，结果显示DR,阳性率为2I.400. DR,基因频率为。. 113，与其它人种间有较大差异     

Evaluation of compatibility of itraconazole with excipients used to develop vesicular colloidal carriers

Liposomes and niosomes are known to be efficient vehicles for localized and systemic delivery of particularly lipophilic drugs resulting in their improved bioavailability, targeted delivery, and fewer side effects. These systems consist of bilayered membrane structures comprising amphiphilic molecules like phosphatidylcholine (liposomes) and nonionic surfactants (niosomes). Itraconazole (ITZ) is a widely used insoluble antifungal agent, which is known to be poorly absorbed from available marketed dosage forms. For countering the bioavailability related problem of oral ITZ products, vesicular systems like liposomes and niosomes could provide a rational approach. Drug–excipient interaction is being considered as an essential first step in development of any drug delivery system nowadays. Therefore, the present work describes the evaluation of drug–excipient interactions of ITZ with selected excipients used for development of liposomes and niosomes. Analytical techniques like differential scanning calorimetry, Fourier transform infrared spectroscopy, optical microcopy, and X-ray powder diffraction analysis were utilized for assessing the drug–excipient interactions. Isothermal stress testing was also performed to quantitatively measure the percent change in initial drug content from ITZ–excipient blends kept under stress conditions. The excipients included phospholipids (Phospholipon 90G^®, Phospholipon 90H^®), surfactants (Span 40 and Span 60), vesicular membrane stabilizer (cholesterol), and a solubilizer (3-hydroxypropyl-betacyclodextrin).