Synthesis of Substituted Aminopyrimidines as Novel Promising Tyrosine Kinase Inhibitors

Russian Journal of Organic Chemistry - A procedure has been proposed for the synthesis of a series of substituted N-(1,3-thiazol-2-yl)-pyrimidin-2-amines and N-(pyrimidin-2-yl)thioureas by...     

Condensation of Isatoic Anhydride with Hetarylguanidines

Condensation of isatoic anhydride with 4-methylquinazolin-2-yl-, 2-benzoxazolyl-, 2-benzothiazolyl-, and 4,6-dimethylpyrimidin-2-ylguanidines leads to the corresponding 2-hetarylamino-4-hydroxyquinazolines as a result of cyclization of intermediate anthranilic acid hetarylguanidides. These intermediates can be isolated as individual compounds.     

2-Quinazolylguanidines in Heterocyclization Reactions. 2. Condensation with α,β-Unsaturated Carbonyl Compounds

4,6,6-Trimethyl-1,4-dihydropyrimidines have been synthesized by condensation of 2-quinazolylguanidines with mesityl oxide. The analogous reaction with benzalacetone leads to unstable 4-methyl-6-phenyl-1,4-dihydropyrimidines, which are oxidized to the corresponding 4-methyl-6-phenylpyrimidines.     

2,2,4-Trimethylhydroquinolines in the Bischler-Melau Reaction

8-R-1-Aryl-4,4,6-trimethyl-4H-pyrrolo[3,2,1-ij]quinolines have been synthesized by the Bischler-Melau reaction in the series of 6-R-2,2,4-trimethylhydroquinolines.     

Reaction of cyanamides with N,N-binucleophiles

Reactions of 4,6-dimethylpyrimidin-2-yl-and aroylcyanamides with benzene-1,2-diamine, ethylenediamine, cyclohexane-1,2-diamine, and naphthalene-1,8-diamine leads to 1H-benzimidazol-2-amine, imidazolidin-2-imine, perhydrobenzimidazol-2-imine, and 1H-perimidin-2-amine derivatives, respectively.