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I. V. Ukrainets N. Yu. Golik A. L. Shemchuk V. N. Kravchenko 《Chemistry of Heterocyclic Compounds》2011,47(9):1122-1127
Hydroxy- and alkoxyanilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids have been synthesized as potential diuretic agents. Features of their purification, their steric
structure, and biological activity are discussed. 相似文献
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Synthesis of novel spiro-condensed 2-amino-4H-pyrans based on 1,2-benzoxathiin-4(3H)-one 2,2-dioxide
Grygoriv Galina V. Lega Dmitry A. Zaprutko Lucjusz Gzella Andrzej K. Wieczorek-Dziurla Ewa Chernykh Valentine P. Shemchuk Leonid A. 《Chemistry of Heterocyclic Compounds》2019,55(3):254-260
Chemistry of Heterocyclic Compounds - A series of new spiro-condensed 2-amino-4H-pyrans were synthesized by three-component interaction of 1,2-benzoxathiin-4(3H)-one 2,2-dioxide, malononitrile, and... 相似文献
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L. A. Shemchuk V. P. Chernykh O. S. Krys’kiv 《Russian Journal of Organic Chemistry》2008,44(7):1006-1008
In the reaction with cyclic anhydrides the anthranilic acid 2-N-phenylhydrazide depending on conditions yielded either anthranilic acid 2-N-acyl-2-N′-phenylhydrazides, 2-R-3-anilinoquinazolin-4(3H)-ones, or derivatives of 1-phenylpyridazino[3,2-b]quinazoline-2,10-dione. 相似文献
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4,3′-Spiro[(6-amino-5-R-3-methyl-2H,4H-pyrano[2,3-c]pyrazolo)-2′-oxindoles] were synthesized based on the three-component condensation of isatins with 3-methyl-pyrazolone-5 and respective methylene active nitriles in the presence of basic catalysts. The molecular structure of the resulting compounds was proved unambiguously by X-ray diffraction. 相似文献
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Leonid A. Shemchuk Dmitry A. Lega Ruslan Gr. Redkin Valentin P. Chernykh Oleg V. Shishkin Svetlana V. Shishkina 《Tetrahedron》2014
Spiro[(2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide)-4,3′-(1′-R′-5′-R″-indolin-2′-one)] compounds were synthesized based on the three-component interaction of benzo[c][2,1]thiazin-4-on 2,2-dioxide with corresponding isatins and appropriate methylene active nitriles in the presence of a base as a catalyst. The molecular structures of the target compounds were proved uniquely by the X-ray diffraction analysis method. 相似文献
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L. A. Shemchuk V. P. Chernykh D. V. Levashov K. M. Sytnik L. M. Shemchuk 《Russian Journal of Organic Chemistry》2010,46(11):1687-1690
By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates
were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines. 相似文献
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L. A. Shemchuk V. P. Chernykh P. S. Arzumanov I. L. Starchikova 《Russian Journal of Organic Chemistry》2007,43(12):1830-1835
Treatment of anthranilic acid hydrazide with 2 equiv of ethoxalyl chloride gave the corresponding diester which underwent cyclization in acetic anhydride to produce ethyl 3-(ethoxalylamino)-4-oxo-3,4-dihydroquinazoline-2-carboxylate. Acylation of anthranilic acid hydrazide first with succinic anhydride and then with ethoxalyl chloride led to the formation of 4-[2-(2-{[ethoxy(oxo)acetyl]amino}benzoyl)hydrazino]-4-oxobutanoic acid whose cyclization in acetic acid afforded N-(2-ethoxycarbonyl-4-oxo-3,4-dihydroquinazolin-3-yl)succinamic acid, while in acetic anhydride ethyl 3-(2,5-dioxopyrrolidin-1-yl)-4-oxo-3,4-dihydroquinazoline-2-carboxylate was obtained. The latter was brought into reactions with amines and hydrazine hydrate and alkaline hydrolysis. Acylation of 2-[2-(2-aminobenzoyl)hydrazinocarbonyl]benzoic acid with ethoxalyl chloride gave ethyl N-[2-(phthalimidocarbamoyl)phenyl]oxamate, and with succinic anhydride, 3-[4-oxo-3-phthalimido-3,4-dihydroquinazolin-2-yl]propionic acid. 4-[2-(2-Aminobenzoyl)hydrazino]-4-oxobutanoic acid reacted with phthalic anhydride in boiling acetic acid to give phthalazino[1,2-b]quinazoline-5,8-dione via elimination of succinic acid residue. 相似文献
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L. A. Shemchuk V. P. Chernykh D. V. Levashov K. M. Sytnik 《Russian Journal of Organic Chemistry》2010,46(8):1243-1245
Ethyl 3-furfuryl-4-oxo-3,4-dihydroquinazoline-2-carboxylate extremely readily undergoes hydrolysis in acid, alkaline, or neutral medium with formation of 2-(2-ethoxy-1,2-dioxoethylamino)-N-furfurylbenzamide. The reaction of ethyl 3-furfuryl-4-oxo-3,4-dihydroquinazoline-2-carboxylate with phenylmagnesium bromide yields N-furfuryl-2-(2-hydroxy-2,2-diphenyl-1-oxoethylamino)benzamide as a result of hydrolytic cleavage of the quinazoline ring. 相似文献