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1.
Olive oil (OO) and its phenolic compounds are reported to possess many potential biological effects, which are ascribed to its powerful antioxidant property. In this study, we have assessed whether OO and its phenolic compound tyrosol (TY) could mitigate 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative damages in peripheral blood mononuclear cells (PBMC). The results showed that exposure of PBMC to 10 nM TCDD caused significant cell death and elevated cellular concentrations of reactive oxygen species and lipid peroxidation. Comet assay indicated that OO and TY protected DNA damage against dioxin toxicity. In addition, alterations in levels of antioxidant enzymes were substantially prevented by OO and TY. TCDD-induced CYP1A1 activity and loss of mitochondrial membrane potential were significantly reduced by the administration of OO and TY. The results suggested that dietary modifications incorporating diets rich in OO and associated phenolics could prove beneficial in protecting individuals against toxicity induced by dioxins. 相似文献
2.
M.R. Prathapachandra Kurup Binu VargheseM. Sithambaresan Suja KrishnanS.R. Sheeja Eringathodi Suresh 《Polyhedron》2011,30(1):70-78
An interesting series of nine new copper(II) complexes [Cu2L2(OAc)2]·H2O (1), [CuLNCS]·½H2O (2), [CuLNO3]·½H2O (3), [Cu(HL)Cl2]·H2O (4), [Cu2(HL)2(SO4)2]·4H2O (5), [CuLClO4]·½H2O (6), [CuLBr]·2H2O (7), [CuL2]·H2O (8) and [CuLN3]·CH3OH (9) of 2-benzoylpyridine-N(4)-phenyl semicarbazone (HL) have been synthesized and physico-chemically characterized. The tridentate character of the semicarbazone is inferred from IR spectra. Based on the EPR studies, spin Hamiltonian and bonding parameters have been calculated. The g values, calculated for all the complexes in frozen DMF, indicate the presence of the unpaired electron in the dx2-y2 orbital. The structure of the compound, [Cu2L2(OAc)2] (1a) has been resolved using single crystal X-ray diffraction studies. The crystal structure revealed monoclinic space group P21/n. The coordination geometry about the copper(II) in 1a is distorted square pyramidal with one pyridine nitrogen atom, the imino nitrogen, enolate oxygen and acetate oxygen in the basal plane, an acetate oxygen form adjacent moiety occupies the apical position, serving as a bridge to form a centrosymmetric dimeric structure. 相似文献
3.
Koteeswari R Ashokkumar P Malar EJ Ramakrishnan VT Ramamurthy P 《Chemical communications (Cambridge, England)》2011,47(27):7695-7697
Amidothiourea linked acridinedione derivatives selectively detect Hg(2+) in unbuffered aqueous solution under broad pH range with both single- and two-photon excitation. The observed linear fluorescence intensity change allows the quantitative detection of Hg(2+) in the concentration range of 22 nM-0.33 μM with the lower detection limit of 2 nM. 相似文献
4.
R. Kumaran T. Varalakshmi E. J. Padma Malar P. Ramamurthy 《Journal of fluorescence》2010,20(5):993-1002
Photophysical studies of photoinduced electron transfer (PET) and non-PET based acridinedione dyes with guanidine hydrochloride
(GuHCl) were carried out in water and methanol. Addition of GuHCl to photoinduced electron transfer (PET) based acridinedione
dye (ADR 1) results in a fluorescence enhancement, whereas a non-PET based dye (ADR 2) shows no significant change in the
fluorescence intensity and lifetime. Addition of GuHCl to ADR 1 dye in methanol results in single exponential decay behaviour,
on the contrary a biexponential decay pattern was observed on the addition of GuHCl in water. Absorption and emission spectral
studies of ADR 1 dye interaction with GuHCl reveals that the dye molecule is not in the protonated form in aqueous GuHCl solution,
and the dye is confined to two distinguishable microenvironment in the aqueous phase. A large variation in the microenvironment
around the dye molecule is created on the addition of GuHCl and this was ascertained by time-resolved area normalized emission
spectroscopy (TRANES) and time-resolved emission spectroscopy (TRES). The dye molecule prefers to reside in the hydrophobic
microenvironment, rather in the hydrophilic aqueous phase is well emphasized by time-resolved fluorescence lifetime studies.
The mechanism of fluorescence enhancement of ADR 1 dye by GuHCl is attributed to the suppression of the PET process occuring
through space. 相似文献
5.
Ravindranath R Ajikumar PK Bahulayan S Hanafiah NB Baba A Advincula RC Knoll W Valiyaveettil S 《The journal of physical chemistry. B》2007,111(23):6336-6343
Ultrathin films of a cross-linked and chemically distinct conjugated poly(p-phenylene) network via electropolymerization are described. The amphiphilic network precursor was synthesized by incorporating the alkoxy carbazole group (-O(CH2)5Cb) to a poly(p-phenylene) (C6PPPOH) backbone. In order to investigate the combined thin film electrochemical and photophysical properties of poly(p-phenylene)s and polycarbazole conjugated polymers, C6PPPC5Cb was deposited on substrates using the Langmuir Blodgett Kuhn (LBK) method. The monolayer isotherm of the polymer, C6PPPC5Cb, showed a liquid expanded region slightly different from the parent polymer C6PPPOH. Multilayers (up to 30 layers) were transferred to different substrates such as quartz, gold coated LaSFN9 and ITO substrates for analysis. For conversion to a conjugated polymer network (CPN) film, the electroactive carbazole group was electropolymerized using cyclic voltammetry (CV) resulting in polycarbazole linking units. The differences in the film properties and corresponding changes in the electrochemical behavior indicate the importance of film thickness and electron/ion transport process in cross linked network films. From the electrochemical studies, the scan rate was found to have a considerable effect on electropolymerization with higher oxidation and reduction peak values found for the rigid network polymer compared to the uncrosslinked polymers. 相似文献
6.
Muthian Shanmugasundaram Srinivasarao Arulananda Babu Raghavachary Raghunathan Ezekiel J. Padma Malar 《Heteroatom Chemistry》1999,10(4):331-336
Synthesis of a series of novel 1,3‐diphe nyl‐4‐arylspiropyrazolines[5.21]‐11‐tetralones has been accomplished in good yield by regioselective 1,3‐dipolar cycloaddition of diphenylnitrilimine with (E)‐2‐arylidene‐1‐tetralones. X‐ray crystal structure analysis of one of the products 4b confirms the structure and the regiochemistry of cycloaddition. © 1999 John Wiley & Sons, Inc. Heteroatom Chem 10: 331–336, 1999 相似文献
7.
Torres DA Azagarsamy MA Thayumanavan S 《Journal of the American Chemical Society》2012,134(17):7235-7237
We report a new approach for the rapid screening of analyte binding affinities for a target protein. We demonstrate that a molecular probe, with a pro-fluorophore substrate and ligand moieties, can be hindered from enzymatic access when bound to the target protein. When analytes displace the probe from the protein's binding pocket, a fluorescence profile is generated. This profile is used to discriminate analytes based on their relative binding affinities. 相似文献
8.
N Selvakumar B.Yadi ReddyA.Malar Azhagan Manoj Kumar KheraJ.Moses Babu Javed Iqbal 《Tetrahedron letters》2003,44(37):7065-7069
A short and efficient route to 1-methoxyindoles via a novel rearrangement is disclosed. This route involves only three steps from commercially available nitro compounds. The methodology is also generalized with a variety of examples to afford a series of 2-substituted-1-methoxyindoles possessing an electron-withdrawing group at position 3. In addition, a 1-methoxyindole compound 10 was converted to the corresponding indole 11 under mild conditions thereby constituting a new synthesis of substituted indoles. 相似文献
9.
N. Selvakumar Manoj Kumar KheraB.Yadi Reddy D. SrinivasA.Malar Azhagan Javed Iqbal 《Tetrahedron letters》2003,44(37):7071-7074
A direct synthesis of naturally occurring 9-methoxycarbazole-3-carbaldehyde 1, based on our methodology for the synthesis of 1-methoxyindoles, is reported. A novel benzannulation strategy was employed using ring closing metathesis as the key step in this total synthesis. The synthesis of the natural product 1 has been achieved in seven steps in 14% overall yield from commercial materials and in only four steps from a methoxyindole compound obtained using the new methodology. 相似文献
10.
Viruthachalam Thiagarajan Chellappan Selvaraju E J Padma Malar Perumal Ramamurthy 《Chemphyschem》2004,5(8):1200-1209
Absorption and emission spectra of 9-N,N-dimethylaniline decahydroacridinedione (DMAADD) have been studied in different solvents. The fluorescence spectra of DMAADD are found to exhibit dual emission in aprotic solvents and single emission in protic solvents. The effect of solvent polarity and viscosity on the absorption and emission spectra has also been studied. The fluorescence excitation spectra of DMAADD monitored at both the emission bands are different. The presence of two different conformation of the same molecule in the ground state has lead to two close lying excited states, local excited (LE) and charge transfer (CT), and thereby results in the dual fluorescence of the dye. A CTstate involving the N,N-dimethylaniline group and the decahy droacridinedione chromophore as donor and acceptor, respectively, has been identified as the source of the long wavelength anomalous fluorescence. The experimental studies were supported by ab initio time dependent-density functional theory (TDDFT) calculations performed at the B3LYP/6-31G* level. The molecule possesses photoinduced electron transfer (PET) quenching in the LE state, which is confirmed by the fluorescence lifetime and fluorescent intensity enhancement in the presence of transition metal ions. 相似文献