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排序方式: 共有199条查询结果,搜索用时 31 毫秒
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Pressurized hot water extraction (PHWE) using a laboratory made system was applied for the extraction of thermally labile and reasonably polar components such as berberine in coptidis rhizoma, glycyrrhizin in radix glycyrrhizae/liquorice and baicalein in scutellariae radix. PHWE was carried out dynamically at a flow of 1 ml/min, temperature between 95 and 140 °C, an applied pressure of 10-20 bar and extraction time of 40 min. Extraction by PHWE was found to give efficiencies comparable to Soxhlet extraction for baicalein in scutellariae radix and sonication for berberine in coptidis rhizoma, and glycyrrhizin in radix glycyrrhizae. Effects of ethanol added into the water used in PHWE were explored. Pressurized liquid extraction (PLE) with methanol as solvent was used for extraction of baicalein in scutellariae radix. The marker compounds present in the various medicinal plant extracts were determined by gradient elution HPLC. 相似文献
4.
Highly cross-linked network polymers prepared by molecular imprinting catalyzed enantioselectively the hydrolysis of N-tert-butoxycarbonyl phenylalanine-p-nitrophenyl ester (BOCPheONP). The templates were designed to allow incorporation of the key catalytic elements, found in the proteolytic enzyme chymotrypsin, into the polymer active sites. Three model systems were evaluated. These were constructed from a chiral phosphonate analogue of phenylalanine (series A, C) or L-phenylalanine (series B) attached by a labile ester linkage to an imidazole-containing vinyl monomer. Free radical copolymerization of the template with methacrylic acid (MAA) and ethylene glycol dimethacrylate (EDMA) gave a highly cross-linked network polymer. The templates could be liberated from the polymers by hydrolysis, giving catalytically active sites envisaged to contain an enantioselective binding site, a site complementary to a transition state like structure (series A, C), and a hydroxyl, imidazole, and carboxylic acid group at hydrogen bond distance. As predicted, the enantiomer of BOCPheONP complementary to the configuration of the template was preferentially hydrolyzed with D-selectivity for the series A polymers (kD/kL = 1.9) and L-selectivity for the series B polymers (kL/kD = 1.2). The maximum rate enhancement, when compared with a control polymer, prepared using a benzoyl-substituted imidazole monomer as template, was 2.5, and comparing with the imidazole monomer in solution, a maximum rate enhancement of 10 was observed. The catalytic activity was higher for polymers subjected to the nucleophilic treatment. This was explained by a higher site density and flexibility of the polymer matrix caused by this treatment. In a comparison of template rebinding to polymers imprinted with a template containing either a carboxylate (planar ground state structure) or a phosphonate (tetrahedral transition state like structure) functionality, it was observed that imprinted polymers are able to discriminate between a transition state like and a ground state structure for transesterification. However the influence of transition state stabilization on the observed rate enhancements remains obscure. Only at acidic pH's was catalysis observed, whereas at basic pH's the polymers inhibit the reaction. At a later stage, the catalytic activity of the polymers for nonactivated D- and L-phenylalanine ethyl esters was investigated. A rate enhancement of up to 3 was observed when compared to the blank. Most important, however, the polymers imprinted with a D template preferentially hydrolyzed the D-ethyl ester and exhibited saturation kinetics. 相似文献
5.
An SCF perturbation method for investigating the effects of an arbitrary change in nuclear configuration on the electronic structure of a molecule is reported. Illustrative calculations for CO2 and CH3OH are presented. It is found that, when taken to second order, the error in the calculated change in energy which results from a change in nuclear configuration is typically in the range of 0.1 to 7%. 相似文献
6.
A "ring expansion-annulation strategy" for the synthesis of substituted azulenes is described based on the reaction of beta'-bromo-alpha-diazo ketones with rhodium carboxylates. The key transformation involves an intramolecular Buchner reaction followed by beta-elimination of bromide, tautomerization, and in situ trapping of the resulting 1-hydroxyazulene as a carboxylate or triflate ester. Further synthetic elaboration of the azulenyl halide and sulfonate annulation products can be achieved by employing Heck, Negishi, Stille, and Suzuki coupling reactions. Reaction of the azulenyl triflate 84 with pinacolborane provides access to the azulenylboronate 91, which participates in Suzuki coupling reactions with alkenyl and aryl iodides. The application of these coupling reactions to the synthesis of biazulenes, terazulene 101, and related oligoazulenes is described, as well as the preparation of the azulenyl amino acid derivative 110. 相似文献
7.
[reaction: see text] A new method for synthesizing the 2-spiro-boraadamantane pyridine complex (2) from 1-ethynylcyclohexylmethyl ether has been developed. The chemistry has been applied to the synthesis of bis-2-spiro-1-boraadamantane.pyridine (1) from trans-1,4-diethynyl-1,4-dimethoxycyclohexane (8). This bis-Lewis acid serves as a self-assembling molecular building block with difunctional Lewis bases. 相似文献
8.
Papastavros E Shea PJ Langell MA 《Langmuir : the ACS journal of surfaces and colloids》2004,20(26):11509-11516
Finely ground and pretreated iron substrates known as "zerovalent iron" or "Fe0" are used as reductants in the environmental remediation of halogenated hydrocarbons, and the composition of their surfaces significantly affects their reactivity. Samples of unannealed and annealed (heat-treated under H2/N2) zerovalent iron were analyzed using X-ray photoelectron spectroscopy (XPS) and Auger electron spectroscopy (AES). Surface concentration of the iron and of the impurities observed by XPS and AES, carbon, chlorine, sulfur, and oxygen, were measured before and after soaking in trichloroethylene (TCE) and in water saturated with TCE (H2O/TCE) to simulate chlorocarbon remediation conditions. Samples pretreated by annealing at high temperature under H2 contained less iron carbide. The carbide contaminant was evident in both iron and carbon XPS spectra, with binding energies of 709.0 and 283.3 eV for the Fe 2p3/2 and C 1s, respectively. The annealed Fe0 surface also contained more sulfur. The carbide concentration was essentially unchanged by TCE and H2O/TCE exposure, whereas the sulfur decreased in proportion to chlorine adsorption following the dechlorination reaction. While oxygen concentration is initially lower on the annealed substrate surface, it rapidly increased during the model TCE remediative treatment process and thus does not represent a significant effect of the annealing process on surface reactivity. 相似文献
9.
Ong ES Len SM Lee AC Chui P Chooi KF 《Rapid communications in mass spectrometry : RCM》2004,18(21):2522-2530
Scutellariae radix or Scutellaria baicalensis is a medicinal plant that contains major flavonoids such as baicalein, baicalin, wogonin and wogonosides. The present work describes the development of an approach using proteomic analysis of mouse liver to study the effects of prolonged exposure to substances present in chemically standardized Scutellariae radix extracts. Histopathological examination of the mouse liver was compared with the proteome data. The botanical extracts were prepared using pressurized liquid extraction (PLE). A method without isotope labeling was developed, using proteolytic digestion with one- and two-dimensional liquid chromatography with tandem mass spectrometry, and was used to characterize the extent of differential protein expression in mouse liver in response to external factors such as extracts from Scutellariae radix. From the histopathological examination and proteome data, significant changes in the mouse livers were not observed for the low-dose group. The Scutellariae radix extracts at high dose were observed to cause damage at the bile duct and expression change of a number of proteins including some involved in catabolism of triglyceride-rich particles, carbohydrate metabolism, regulators of cell signaling processes, and enzymes involved in biotransformation. Thus, proteomic analysis of liver samples from mice treated with botanical extracts is a promising approach to provide information on any potential toxicity effects of the extracts. The present method also provides another means for comparing proteomes in biological samples such as liver lysates from mice subjected to different treatments. 相似文献
10.
Shea KJ 《Chemistry (Weinheim an der Bergstrasse, Germany)》2000,6(7):1113-1119
The polymerization of dimethylsufoxonium methylide to produce linear polymethylene polymers is described. The reaction is catalyzed/initiated by trialkylboranes and gives organoboron star polymers as the primary product. The reaction is a living polymerization, providing control over molecular weight and functionality at the polymer chain ends. A variety of novel polymethylene architectures are available by this methodology. 相似文献