排序方式: 共有47条查询结果,搜索用时 187 毫秒
1.
Muddaser Shah Waheed Murad Najeeb Ur Rehman Sobia Ahsan Halim Manzoor Ahmed Hazir Rehman Muhammed Zahoor Sidra Mubin Ajmal Khan Mohamed A. Nassan Gaber El-Saber Batiha Ahmed Al-Harrasi 《Molecules (Basel, Switzerland)》2021,26(12)
In the current study, in vitro antimicrobial and antioxidant activities and in vivo anti-inflammatory and analgesic activities of Scutellaria edelbergii Rech. f. (crude extract and subfractions, i.e., n-hexane, ethyl acetate (EtOAc), chloroform, n-butanol (n-BuOH) and aqueous) were explored. Initially, extraction and fractionation of the selected medicinal plant were carried out, followed by phytochemical qualitative tests, which were mostly positive for all the extracts. EtOAc fraction possessed a significant amount of phenolic (79.2 ± 0.30 mg GAE/g) and flavonoid (84.0 ± 0.39 mg QE/g) content. The EtOAc fraction of S. edelbergii exhibited appreciable antibacterial activity against Gram-negative (Escherichia coli and Klebsiella pneumoniae) strains and significant zones of inhibition were observed against Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus). However, it was found inactive against Candida Albicans and Fusarium oxysporum fungal strains. The chloroform fraction was the most effective with an IC50 value of 172 and 74 µg/mL against DPPH (1,1-Diphenyl-2-picryl-hydrazyl) and ABTS assays, in comparison with standard ascorbic acid 59 and 63 µg/mL, respectively. Moreover, the EtOAc fraction displayed significant in vivo anti-inflammatory activity (54%) using carrageenan-induced assay and significant (55%) in vivo analgesic activity using acetic acid-induced writing assay. In addition, nine known compounds, ursolic acid (UA), ovaul (OV), oleanolic acid (OA), β-sitosterol (BS), micromeric acid (MA), taraxasterol acetate (TA), 5,3′,4′-trihydroxy-7-methoxy flavone (FL-1), 5,7,4′-trihydroxy-6,3′-dimiethoxyflavone (FL-2) and 7-methoxy catechin (FL-3), were isolated from methanolic extract of S. edelbergii. These constituents have never been obtained from this source. The structures of all the isolated constituents were elucidated by spectroscopic means. In conclusion, the EtOAc fraction and all other fractions of S. edelbergii, in general, displayed a significant role as antibacterial, free radical scavenger, anti-inflammatory and analgesic agents which may be due to the presence of these constituents and other flavonoids. 相似文献
2.
Koruyucu Elif Ekici Selcuk Karakoc T. Hikmet 《Journal of Thermal Analysis and Calorimetry》2021,145(3):1303-1315
Journal of Thermal Analysis and Calorimetry - This study presents determining performance parameters as well as thermodynamic analysis through certain design parameters of a two-spool turbojet... 相似文献
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Selcuk Denizligil Aysegul Baskan Yusuf Yagci 《Macromolecular rapid communications》1995,16(5):387-391
The polymerization of tetrahydrofuran was initiated with 4,4′-azobis(4-cyanovaleryl chloride) in conjunction with silver hexafluoroantimonate and the living polytetrahydrofuran (PTHF) was terminated with pyridinium N-oxide derivatives. The resulting PTHF-macroinitiator possesses both a thermally and photochemically labile group. 相似文献
5.
Xun?Gu Selcuk?Akturk Aparna?Shreenath Qiang?Cao Rick?TrebinoEmail author 《Optical Review》2004,11(3):141-152
We review the state of the art of ultrashort-light-pulse measurement using frequency-resolved-optical-gating (FROG). Recent developments have extended the state of the art considerably. FROG devices for measuring the intensity and phase of ultrashort laser pulses have become so simple that almost no alignment is required. In addition, such devices not only operate single shot, but they also yield the two most important spatio-temporal distortions, spatial chirp and pulse-front tilt. With other FROG variations, it is now possible to measure more general ultrashort light pulses (i.e., pulses much more complex than common laser pulses), with time-bandwidth products as large as several thousand and as weak as a few hundred photons, and despite other difficulties such as random absolute phase and poor spatial coherence. 相似文献
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In this note we show that various branch and bound methods for solving continuous global optimization problems can be readily adapted to the discrete case. As an illustration, we present an algorithm for minimizing a concave function over the integers contained in a compact polyhedron. Computational experience with this algorithm is reported. 相似文献
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The Ramanujan Journal - We compute Fourier series expansions of weight 2 and weight 4 Eisenstein series at various cusps. Then we use results of these computations to give formulas for the... 相似文献
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Given the NP-Hard nature of many optimization problems, it is often impractical to obtain optimal solutions to large-scale
problems in reasonable computing time. For this reason, heuristic and metaheuristic search approaches are used to obtain good
solutions fast. However, these techniques often struggle to develop a good balance between local and global search. In this
paper we propose a hybrid metaheuristic approach which we call the NeuroGenetic approach to search for good solutions for
these large scale optimization problems by at least partially overcoming this challenge. The proposed NeuroGenetic approach
combines the Augmented Neural Network (AugNN) and the Genetic Algorithm (GA) search approaches by interleaving the two. We
chose these two approaches to hybridize, as they offer complementary advantages and disadvantages; GAs are very good at searching
globally, while AugNNs are more proficient at searching locally. The proposed hybrid strategy capitalizes on the strong points
of each approach while avoiding their shortcomings. In the paper we discuss the issues associated with the feasibility of
hybridizing these two approaches and propose an interleaving algorithm. We also provide empirical evidence demonstrating the
effectiveness of the proposed approach. 相似文献
9.
Huseyin Selcuk Kilic 《Applied Mathematical Modelling》2013,37(14-15):7752-7763
One of the important stages in supply chain management which regards all the activities from the purchasing of raw material to final delivery of the product is the supplier selection process. Since it is the first stage of the supply chain management, it is a critical process affecting the consecutive stages. It is simply desired to select the best supplier for a specific product. But since there are a lot of criteria and alternatives to be considered, numerous decision making models have been proposed to provide a solution to this problem. Within this study, an integrated approach including fuzzy Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) and a mixed integer linear programming model is developed to select the best supplier in a multi-item/multi-supplier environment. The importance value of each supplier with respect to each product is obtained via fuzzy TOPSIS in the first stage. Then in the second stage, these values are used as an input in the mathematical model which determines the suppliers and the quantities of products to be provided from the related suppliers. So as to validate the proposed methodology, an application is performed in air filter sector. 相似文献
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Megha Sen Chowdhury Dr. Selcuk Gumus Dr. Sanchari Dasgupta Dr. Ishani Majumder Dr. Abir Bhattacharya Dr. Debasis Das Dr. Jayanta Mukhopadhyay Dr. Debosreeta Bose Dr. Saumya Dasgupta Dr. Yuksel Akinay Dr. Madhumita Mukhopadhyay 《ChemistryOpen》2022,11(6):e202200033
We report, for the first time, a detailed crystallographic study of the supramolecular arrangement for a set of zinc(II) Schiff base complexes containing the ligand 2,6-bis((E)-((2-(dimethylamino)ethyl)imino)methyl)-4-R-phenol], where R=methyl/tert-butyl/chloro. The supramolecular study acts as a pre-screening tool for selecting the compartmental ligand R of the Schiff base for effective binding with a targeted protein, bovine serum albumin (BSA). The most stable hexagonal arrangement of the complex [Zn − Me] (R=Me) stabilises the ligand with the highest FMO energy gap (ΔE=4.22 eV) and lowest number of conformations during binding with BSA. In contrast, formation of unstable 3D columnar vertebra for [Zn − Cl] (R=Cl) tend to activate the system with lowest FMO gap (3.75 eV) with highest spontaneity factor in molecular docking. Molecular docking analyses reported in terms of 2D LigPlot+ identified site A, a cleft of domains IB, IIIA and IIIB, as the most probable protein binding site of BSA. Arg144, Glu424, Ser428, Ile455 and Lys114 form the most probable interactions irrespective of the type of compartmental ligands R of the Schiff base whereas Arg185, Glu519, His145, Ile522 act as the differentiating residues with ΔG=−7.3 kcal mol−1. 相似文献