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Synthesis of poly(ester‐amide) dendrimers based on 2,2‐Bis(hydroxymethyl) propanoic acid and glycine
David Pahovnik Anja Čusak Sebastjan Reven Ema Žagar 《Journal of polymer science. Part A, Polymer chemistry》2014,52(22):3292-3301
Water‐soluble, biodegradable, and biocompatible poly(ester‐amide) dendrimers with hydroxyl functional groups are synthesized from previously prepared AB2 adduct of 2,2‐bis(hydroxymethyl) propanoic acid (bis‐MPA) and glycine as a repeating unit. Two esterification procedures using different coupling reagent/catalyst systems (DCC/DPTS or EDC/DMAP) are studied with respect to efficiency, ease of products purification, and quality of the final products. Both procedures have their own benefits and drawbacks, depending on dendrimer generation. The synthesized poly(ester‐amide) dendrimers as well as commercially available bis‐MPA dendrimers, poly(ester‐amide) hyperbranched polymer, and poly(vinyl alcohol) are used for preparation of solid dispersions of sulfonylurea antidiabetic drug glimepiride to improve its poor water‐solubility. In vitro dissolution studies show in comparison with pure glimepiride in crystalline or amorphous form, to the same extent improved glimepiride solubility for solid dispersions based on dendritic polymers, but not for poly(vinyl alcohol). The amount of glimepiride complexed with both dendrimer types increases with dendrimer generation. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52, 3292–3301 相似文献
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Sebastjan Glin?ek Iztok Ar?on Barbara Mali? Alojz Kodre Marija Kosec 《Journal of Sol-Gel Science and Technology》2012,62(1):1-6
The KTa0.6Nb0.4O3 sols for chemical solution deposition of thin films were prepared from potassium acetate and transition metal ethoxides by
the 2-methoxyethanol based route. The local environment of both transition metals after reflux times 1, 4, 24, and 48 h, whereby
the crystallization behavior of the films was strongly affected, was monitored by extended X-ray absorption fine structure
spectroscopy, at Ta L3 and Nb K edges. The Ta species existed in the sols as monomers, remaining stable even with prolonged reflux time. The Ta–O–K
correlations were confirmed in all cases. In contrast, the Nb-alkoxide formed dimers, with a gradual formation of oligomeric
species with prolonged refluxing. The Nb–O–K correlations were present after all reflux times. The number of K neighbours
around Nb increased upon refluxing, saturating at 24 h. 相似文献
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Gačnik Lojze Ambrožič Klemen Rupnik Sebastjan Radulović Vladimir Jaćimović Radojko 《Journal of Radioanalytical and Nuclear Chemistry》2018,315(3):711-721
Journal of Radioanalytical and Nuclear Chemistry - We suspected that changes in the neutron spectrum, caused by varying control rod positions in routine steady state operation of our TRIGA nuclear... 相似文献
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