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1.
D. Bisello G. Busetto A. Castro M. Nigro M. Penzo L. Pescara M. Posocco P. Sartori L. Stanco Z. Ajaltouni A. Falvard J. Jousset B. Michel J. C. Montret A. Antonelli R. Baldini A. Calcaterra G. Capon M. Schioppa J. -E. Augustin G. Cosme F. Couchot B. Dudelzak F. Fulda G. Grosdidier B. Jean-Marie S. Jullian D. Lalanne V. Lepeltier F. Manè C. Paulot R. Riskalla Ph. Roy G. Szklarz DM Collaboration 《Zeitschrift fur Physik C Particles and Fields》1988,39(1):13-19
Thee + e ?→K + K ? cross section has been measured from about 750 events in the energy interval \(1350 \leqq \sqrt s \leqq 2400 MeV\) with the DM2 detector at DCI. TheK ± form factor |F F ±| cannot be explained by the ρ, ω, ? and ρ′(1600). An additional resonant amplitude at 1650 MeV has to be added as suggested by a previous experiment. 相似文献
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J. -E. Augustin G. Cosme F. Couchot B. Dudelzak F. Fulda B. Grelaud G. Grosdidier B. Jean-Marie S. Jullian D. Lalanne V. Lepeltier B. Louis F. Mané C. Paulot R. Riskalla Ph. Roy F. Rumpf G. Szklarz Z. Ajaltouni A. Falvard J. Jousset B. Michel J. C. Montret R. Baldini S. Calcaterra G. Capon D. Bisello G. Busetto S. Limentani M. Nigro L. Pescara M. Posocco P. Sartori L. Stanco DM Collaboration 《Zeitschrift fur Physik C Particles and Fields》1987,36(3):369-376
The radiative decayJ/ψ → γ π+ π? has been studied using the 8.6 millionJ/ψ produced in the DM2 experiment at the DCIe +e? storage rings at Orsay. The π+ π? mass spectrum shows a cleanf 2 (1270) signal, and the possible presence of two other states at thef 2 (1720) andf 4 (2030) masses. For thef 2 (1270), the branching ratio BR(J/ψ →γf)xBR(f→π+ π?) is measured to be (7.50±0.30±1.12)×10?4, and the spin analysis prefers theJ=2 assignment, with helicity parametersx=0.83±0.06 andy=0.01±0.06. The existence of higher mass states is discussed. 相似文献
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K.R. Sidman A.D. Schwope W.D. Steber S.E. Rudolph S.B. Poulin 《Journal of membrane science》1980,7(3):277-291
Polymer pellets that contain drugs and may be implanted under the skin offer effective means for providing sustained, controlled drug therapy to humans and animals. Among the most useful drug delivery systems are those based on biodegradable polymers that ultimately are absorbed by the body — eliminating the need for their surgical removal. Copolymers of L-glutamic acid and γ-ethyl L-glutamate biodegrade to L-glutamic acid and ethanol, at rates that are determined by the initial copolymer composition. The materials are permeable to a wide range of drugs, including steroids, narcotic antagonists, peptide hormones, antimalarials, and anticancer agents. When fabricated into matrix rods or capsules, the copolymers have been used to release drugs in animals at constant rates for prolonged periods of time. p]In this study, rods composed of a blend of drug and copolymer were found to be useful for the long-term release (i.e., 6 to 24 months) of drugs having low aqueous solubility, such as progesterone and levonorgestrel. Capsules, composed of a copolymer sheath surrounding the drug, were better suited for shorter durations of release (i.e., up to 6 months) of drugs having higher aqueous solubility, such as luteinizing hormone-releasing hormone and naltrexone. The physical dimensions and copolymer compositions of either dosage form were readily varied to meet specific delivery rate and duration objectives while satisfying equally important degradation requirements. 相似文献
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The steady propagation of a thin smouldering front in a half-spacehas been considered. A suitable coordinate transformation hasallowed the region near the leading edge of the front to beexamined for both a maintained planar surface and with surfacecollapse due to material shrinkage. The change in the oxidizerconcentration for a small increment in the propagation speedfor large time and surface collapse has been determined. Theinfluence of two types of nonlinear diffusion on the shape ofthe smouldering front has been found; other cases can be dealtwith in a similar manner. 相似文献
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Milman G Barnes AJ Schwope DM Schwilke EW Goodwin RS Kelly DL Gorelick DA Huestis MA 《Analytical and bioanalytical chemistry》2011,401(2):599-607
Oral fluid (OF) is an increasingly accepted matrix for drug testing programs, but questions remain about its usefulness for
monitoring cannabinoids. Expectorated OF specimens (n = 360) were obtained from 10 adult daily cannabis smokers before, during, and after 37 20-mg oral Δ9-tetrahydrocannabinol (THC) doses over 9 days to characterize cannabinoid disposition in this matrix. Specimens were extracted
and analyzed by gas chromatography–mass spectrometry with electron-impact ionization for THC, 11-hydroxy-THC, cannabidiol,
and cannabinol, and negative chemical ionization for 11-nor-9-carboxy-THC (THCCOOH). Linear ranges for THC, 11-hydroxy-THC,
and cannabidiol were 0.25–50 ng/mL; cannabinol 1–50 ng/mL; and THCCOOH 5–500 pg/mL. THCCOOH was the most prevalent analyte
in 344 specimens (96.9%), with concentrations up to 1,390.3 pg/mL. 11-hydroxy-THC, cannabidiol, and cannabinol were detected
in 1, 1, and 3 specimens, respectively. THC was detected in only 13.8% of specimens. The highest THC concentrations were obtained
at admission (median 1.4 ng/mL, range 0.3–113.6) from previously self-administered smoked cannabis. A total of 2.5 and 3.7%
of specimens were THC-positive at the recommended Substance Abuse and Mental Health Services Administration (2 ng/mL) and
Driving Under the Influence of Drugs, Alcohol and Medicines (DRUID) (1 ng/mL) confirmation cutoffs, respectively. THC is currently
the only analyte for monitoring cannabis exposure in OF; however, these data indicate chronic therapeutic oral THC administration
and illicit oral THC use are unlikely to be identified with current guidelines. Measurement of THCCOOH may improve the detection
and interpretation of OF cannabinoid tests and minimize the possibility of OF contamination from passive inhalation of cannabis
smoke. 相似文献
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D. Bisello G. Busetto A. Castro M. Nigro L. Pescara M. Posocco P. Sartori L. Stanco A. Antonelli M. E. Biagini R. Baldini A. Calcaterra M. Schioppa J. E. Augustin G. Cosme F. Couchot F. Fulda G. Grosdidier B. Jean-Marie V. Lepeltier G. Szklarz DM Collaboration 《Zeitschrift fur Physik C Particles and Fields》1990,48(1):23-28
Search for baryon pairs production ine + e ? annihilation at \(\sqrt s = 2386 MeV\) is reported. The data relate to a luminosity of 161 nb?1 collected by the DM2 experiment at DCI, the Orsay colliding ring. First measurements of directe + e ? annihilation into \(\Lambda \bar \Lambda \) and ofe + e ?→ \(p\bar p\) at this energy are presented. First observation of a goode + e ?→ \(n\bar n\) candidate is reported and upper limits are given fore + e ?→ \(n\bar n, \Lambda \bar \sum ^0 + c.c.\) and \(\Sigma ^0 \bar \Sigma ^0 \) . 相似文献
9.
Altman RK Schwope I Sarracino DA Tetzlaff CN Bleczinski CF Richert C 《Journal of combinatorial chemistry》1999,1(6):493-508
Reported here is how modified oligonucleotides with increased affinity for DNA or RNA target strands can be selected from small combinatorial libraries via spectrometrically monitored selection experiments (SMOSE). The extent to which target strands retard the degradation of 5'-acyl-, 5'-aminoacyl-, and 5'-dipeptidyl-oligodeoxyribonucleotides by phosphodiesterase I (EC 3.1.4.1) was measured via quantitative MALDI-TOF mass spectrometry. Oligonucleotide hybrids were prepared on solid support, and nuclease selections were performed with up to 10 modified oligonucleotides in one solution. The mass spectrometrically monitored experiments required between 120 and 300 pmol of each modified oligonucleotide, depending on whether HPLC-purified or crude compounds were employed. Data acquisition and analysis were optimized to proceed in semiautomated fashion, and functions correcting for incomplete degradation during the monitoring time were developed. Integration of the degradation kinetics provided "protection factors" that correlate well with melting points obtained with traditional UV melting curves employing single, pure compounds. Among the components of the five libraries tested, three were found to contain 5'-substituents that strongly stabilize Watson--Crick duplexes. Selecting and optimizing modified oligonucleotides via monitored nuclease assays may offer a more efficient way to search for new antisense agents, hybridization probes, and biochemical tools. 相似文献