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Saira Shahzadi Saqib Ali Khadija Shahid Saroj K. Sharma Kushal Qanungo 《Phosphorus, sulfur, and silicon and the related elements》2013,188(10):2045-2053
A new series of organotin(IV) complexes of aniline derivatives, R2SnL2 and R3SnL [where R = Me, n-Bu, n-Oct, and Ph], have been synthesized by the reaction of ligand acid with respective organotin halides in the presence of triethylamine as base or dioctyltin oxide using a Dean–Stark trap for the removal of water under reflux conditions. Experimental details for the preparation and characterization, including elemental analysis, IR, semi-empirical study, multinuclear NMR (1H, 13C, and 119Sn spectra and EI mass spectral studies) of all reported complexes are provided. The IR data indicate that in both di- and triorganotin(IV) carboxylates, the ligand moiety ?COO acts as a bidentate group in the solid state. Multinuclear NMR data show that triorganotin complexes exhibits a four-coordinated geometry, while diorganotin(IV) complexes show a coordination number greater than four, probably five or six, in solution state. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
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Shabbir Hussain Saqib Ali Saira Shahzadi Corrado Rizzoli 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):812-818
Abstract A novel polymeric complex has been synthesized by refluxing disodium acetylene dicarboxylate with tributyltin chloride in dry methanol. The solid-state structure of the complex has been determined by single-crystal X-ray analysis. The tin(IV) metal exhibits distorted trigonal bipyramidal geometry. Each carboxylate group of the ligand acts in a bidentate fashion, linking adjacent metal atoms to produce polymeric chains, which are cross-linked into a three-dimensional network. 相似文献
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Transition Metal Chemistry - A facile synthetic approach has been adopted towards the synthesis of (2R,3R)-N2,N3-bis((S)-1-phenylethyl)butane-2,3-diamine via demetalation of its dichloro Zn(II)... 相似文献
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Hina Bhargava N. Lakshmi Ram Kripal Sharma K. Venugopalan 《Hyperfine Interactions》2008,183(1-3):155-161
Low temperature Mössbauer and AC susceptibility have been used to study relaxation phenomena in nano-sized particles of Cr0.25Co0.25Zn0.5Fe2O4. From these studies, the energy density constant for this system has been estimated to be 4 x 106 erg/cm3. Cation distribution has also been determined and the observed results are correlated to calculated relaxation times. 相似文献
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Shabbir Hussain Saira Shahzadi Muhammad Shahid Asif Ali Tahir Syed Mustansar Abbas 《Journal of Coordination Chemistry》2017,70(24):4070-4092
Bimetallic chlorodi-/triorganotin(IV) derivatives of general formulas R2(H2O)SnLCSSSn(Cl)R2 (R=Me: 1; Ph: 2) and R3Sn(Na)LCSSSnR3·H2O (R=Bu: 3; Ph: 4) were prepared by reaction of iminodiacetic acid disodium salt hydrate (Na2LH) with CS2 and R2SnCl2/R3SnCl in methanol. The reaction between Na2LH, CS2, and PdCl2 produced [Na2LCSS]2Pd·2H2O (5) which was treated with R3SnCl to synthesize the heterobimetallic derivatives [R3Sn(Na)LCSS]2Pd·2H2O (R=Me: 6; Ph: 7). The complexes were characterized by microanalysis, spectroscopic, and thermogravimetric analyses. Elemental analysis data, mass fragmentation, and thermal degradation patterns supported the molecular composition of the complexes. FT-IR data indicated monodentate binding of carboxylate while a chelating coordination mode of the dithiocarboxylate was verified in the solid state. A five-coordinate tin(IV) was demonstrated in the solid state. In solution, a tetrahedral/trigonal bipyramidal configuration around Sn(IV) and a square planar geometry of Pd(II) was indicated by multinuclear NMR (1H and 13C) and UV-visible studies. The Pd(II) derivatives showed interaction with salmon sperm-DNA and caused an inhibition of alkaline phosphatase (ALPs). The antibacterial/antifungal potential of the coordination products varied with the nature of incorporated metal and a substitution pattern at tin(IV); the palladium metallation decreased the antimicrobial activities. The triorganotin(IV) products exhibited more powerful action against bacteria/fungi as compared to their diorganotin(IV) counterparts. The complexes displayed sufficiently lower hemolytic effects in vitro as compared to triton X-100 and slightly higher than PBS. 相似文献
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Saira Hussain Ata ur Rehman David J. Luckett Syed Muhammad Saqlan Naqvi Christopher L. Blanchard 《Molecules (Basel, Switzerland)》2021,26(7)
Valorization of vegetable oil waste residues is gaining importance due to their high protein and polyphenol contents. Protease inhibitors (PIs), proteins from these abundantly available waste residues, have recently gained importance in treating chronic diseases. This research aimed to use canola meal of genetically diverse Brassica napus genotypes, BLN-3347 and Rivette, to identify PIs with diverse functionalities in therapeutic and pharmacological applications. The canola meal PI purification steps involved: native PAGE and trypsin inhibition activity, followed by ammonium sulfate fractionation, anion exchange, gel filtration, and reverse-phase chromatography. The purified PI preparations were characterized using SDS-PAGE, isoelectric focusing (IEF), and N terminal sequencing. SDS-PAGE analysis of PI preparations under native reducing and nonreducing conditions revealed three polymorphic PIs in each genotype. The corresponding IEF of the genotype BLN-3347, exhibited three acidic isoforms with isoelectric points (pI) of 4.6, 4.0, and 3.9, while Rivette possessed three isoforms, exhibiting two basic forms of pI 8.65 and 9.9, and one acidic of pI 6.55. Purified PI preparations from both the genotypes displayed dipeptidyl peptidase-IV (DPP-IV) and angiotensin-converting enzyme (ACE) inhibition activities; the BLN-3347 PI preparation exhibited a strong inhibitory effect with lower IC50 values (DPP-IV 37.42 µg/mL; ACE 129 µg/mL) than that from Rivette (DPP-IV 67.97 µg/mL; ACE 376.2 µg/mL). In addition to potential human therapy, these highly polymorphic PIs, which can inhibit damaging serine proteases secreted by canola plant pathogens, have the potential to be used by canola plant breeders to seek qualitative trait locus (QTLs) linked to genes conferring resistance to canola diseases. 相似文献
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Saira Shahzadi Moazzam H. Bhatti Khadija Shahid Saqib Ali Saadia R. Tariq Mohammad Mazhar Khalid M. Khan 《Monatshefte für Chemie / Chemical Monthly》2002,133(8):1089-1096
Summary. Tributyltin(IV) derivatives of six different pharmaceutically active carboxylates were synthesized. The complexes were characterized
by different analytical techniques (elemental analysis; infrared, NMR, and mass spectroscopy). 119Sn NMR data were also recorded in six different coordinating and non-coordinating solvents. The antibacterial activities of
the compounds were tested using ten different bacteria relative to the reference drugs ampicillin and cephalexin.
Received September 20, 2001. Accepted (revised) December 6, 2001 相似文献
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Abstract (4-Methylpiperidine-dithiocarbamato-S,S′)triphenyltin(IV) derivative of 4-methyl-1-piperidine carbodithioic acid (4-MePCDTA) have been synthesized and characterized
by elemental, IR, multinuclear NMR (1H and 13C) and mass spectrometric studies. The crystal structure of the complex has been determined by X-ray single crystal analysis,
which shows unsymmetrical nature of the ligand towards coordination to tin. It crystallizes in monoclinic P21/c space group with the crystal cell parameters: a = 10.1863(10) ?, b = 21.200(2) ?, c = 11.7332(11) ?, β = 111.2020(10)°, Z = 4 and V = 2,362.2(4) ?3. The tin atom is coordinated to the two sulfur atoms of the dithiocarbamate ligand and three carbon atoms of the phenyl groups
are in distorted trigonal bipyramid geometry. This complex was tested for its antimicrobial activity against six different
plant and human pathogens. The screening results show that the complex exhibit higher antibacterial and antifungal activity
than the free ligand.
Index abstract
Synthesis, Spectroscopy, in vitro Biological Activity and X-Ray Structure of (4-Methylpiperidine-dithiocarbamato-S,S′)triphenyltin(IV)
Saira Shahzadi, Saqib Ali and Mohammmed Fettouhi
4-Methyl-1-piperidine carbodithioic acid behaves as anisobidentate ligand and chelates the tin atom by means of sulfur atoms
giving cis-trigonal bipyramid geometry around the tin atom.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
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