排序方式: 共有2条查询结果,搜索用时 15 毫秒
1
1.
2.
Ravi Gukathasan Indranil Gupta Siegmar Pulst Yogesh S. Sanghvi Scott A. Laneman 《Journal of organometallic chemistry》2005,690(10):2603-2607
A large-scale, cost-effective, and environmentally clean synthesis of high purity 2-cyanoethyl-N,N,N′,N′-tetraisopropylphosphorodiamidite (Phos reagent) has been accomplished on a commercial scale. Treatment of PCl3 with diisopropylamine followed by 3-hydroxylpropionitrile furnished the Phos reagent in excellent yield. The 31P NMR of the Phos reagent prepared at large-scale show consistent purities >99% when several key factors are controlled. These controlling factors include sourcing high purity key raw materials, identification and elimination of critical impurities, stability and storage of Phos reagent. 相似文献
1