Production and evaluation of a 67Ga-labeled anti-Ror1 monoclonal antibody in a mouse model of breast cancer

Journal of Radioanalytical and Nuclear Chemistry - Receptor tyrosine kinase Ror1 is widely expressed during embryogenesis but it is absent within most mature tissues. However, expression of Ror1...     

Application of Homotopy Perturbation Method and Variational Iteration Method to Nonlinear Oscillator Differential Equations

In this paper, homotopy perturbation method (HPM) and variational iteration method (VIM) are applied to solve nonlinear oscillator differential equations. Illustrative examples reveal that these methods are very effective and convenient for solving nonlinear differential equations. Moreover, the methods do not require linearization or small perturbation. Comparisons are also made between the exact solutions and the results of the homotopy perturbation method and variational iteration method in order to prove the precision of the results obtained from both methods mentioned.     

Reaction of Primary Alkylamines,Heterocumulenes, and Isatoic Anhydride,Catalyzed by Magnetic Fe3O4 Nanoparticles in H2O

An efficient protocol for the one‐pot reaction of isatoic anhydride (=1,2‐dihydro‐4H‐3,1‐benzoxazine‐2,4‐dione), primary alkylamines, and heterocumulenes (isothiocyanates and isocyanates) in H₂O catalyzed by magnetically recoverable Fe₃O₄ nanoparticles is described.     

Compact formulations of the Steiner Traveling Salesman Problem and related problems

The Steiner Traveling Salesman Problem (STSP) is a variant of the TSP that is particularly suitable when routing on real-life road networks. The standard integer programming formulations of both the TSP and STSP have an exponential number of constraints. On the other hand, several compact formulations of the TSP, i.e., formulations of polynomial size, are known. In this paper, we adapt some of them to the STSP, and compare them both theoretically and computationally. It turns out that, just by putting the best of the formulations into the CPLEX branch-and-bound solver, one can solve instances with over 200 nodes. We also briefly discuss the adaptation of our formulations to some related problems.     

Management of supply chain: an alternative modelling technique for forecasting

Forecasting is a necessity almost in any operation. However, the tools of forecasting are still primitive in view of the great strides made by research and the increasing abundance of data made possible by automatic identification technologies, such as radio frequency identification (RFID). The relationship of various parameters that may change and impact decisions are so abundant that any credible attempt to drive meaningful associations are in demand to deliver the value from acquired data. This paper proposes some modifications to adapt an advanced forecasting technique (GARCH) with the aim to develop it as a decision support tool applicable to a wide variety of operations including supply chain management (SCM). We have made an attempt to coalesce a few different ideas toward a ‘solutions’ approach aimed to model volatility and in the process, perhaps, better manage risk. It is possible that industry, governments, corporations, businesses, security organizations, consulting firms and academics with deep knowledge in one or more fields, may spend the next few decades striving to synthesize one or more models of effective modus operandi to combine these ideas with other emerging concepts, tools, technologies and standards to collectively better understand, analyse and respond to uncertainty. However, the inclination to reject deep-rooted ideas based on inconclusive results from pilot projects is a detrimental trend and begs to ask the question whether one can aspire to build an elephant using mouse as a model.     

Synthesis of novel spiro[benzo[4,5]thiazolo[3,2-a]chromeno[2,3-d]pyrimidine-14,3′-indoline]-1,2′,13(2H)-triones via three component reaction

A new and efficient method for the synthesis of hitherto unreported spiro[benzo[4,5]thiazolo[3,2-a]chromeno[2,3-d]pyrimidine-14,3′-indoline]-1,2′,13(2H)-triones was developed via the Domino Knoevenagel condensation–Michael addition–intermolecular cyclization sequences of isatin derivatives, cyclohexane-1,3-diones, and 2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones, employing 12-tungstophosphoric acid (H₃PW₁₂O₄₀) as an effective and inexpensive catalyst.     

Numerical analysis on longitudinal location optimization of vortex generator in compact heat exchangers

In this paper, numerical, curvilinear and turbulent model has been used to investigate the effect of vortex generator's longitudinal displacement on heat transfer and fluid flow in different Reynolds numbers ranging from 500 to 3000. The numerical model has been validated with experimental results of a former study, which is resembled in a particular case. Numerical simulation shows that the vorticity enhancement would increase both Nusselt number and pressure drop. Proposed trend is not constant and the pattern in which parameters change is dependent on Reynolds number. Finally, a conjugated optimization of pressure drop and the Nusselt number has been suggested based on the order of parameter changes. Copyright © 2010 John Wiley & Sons, Ltd.     

Investigation of a powerful analytical method into natural convection boundary layer flow

The natural convection boundary layer flow modeled by a system of nonlinear differential equations is considered. By means of similarity transformation, the non-linear partial differential equations are reduced to a system of two coupled ordinary differential equations. The series solutions of coupled system of equations are constructed for velocity and temperature using homotopy analysis method (HAM). Convergence of the obtained series solution is discussed. Finally some figures are illustrated to show the accuracy of the applied method and assessment of various prandtl numbers on the temperature and the velocity is undertaken.     

Mechanosensitive Membrane Probes

This article assembles pertinent insights behind the concept of planarizable push–pull probes. As a response to the planarization of their polarized ground state, a red shift of their excitation maximum is expected to report on either the disorder, the tension, or the potential of biomembranes. The combination of chromophore planarization and polarization contributes to various, usually more complex processes in nature. Examples include the color change of crabs or lobsters during cooking or the chemistry of vision, particularly color vision. The summary of lessons from nature is followed by an overview of mechanosensitive organic materials. Although often twisted and sometimes also polarized, their change of color under pressure usually originates from changes in their crystal packing. Intriguing exceptions include the planarization of several elegantly twisted phenylethynyl oligomers and polymers. Also mechanosensitive probes in plastics usually respond to stretching by disassembly. True ground‐state planarization in response to molecular recognition is best exemplified with the binding of thoughtfully twisted cationic polythiophenes to single‐ and double‐stranded oligonucleotides. Molecular rotors, en vogue as viscosity sensors in cells, operate by deplanarization of the first excited state. Pertinent recent examples are described, focusing on λ‐ratiometry and intracellular targeting. Complementary to planarization of the ground state with twisted push–pull probes, molecular rotors report on environmental changes with quenching or shifts in emission rather than absorption. The labeling of mechanosensitive channels is discussed as a bioengineering approach to bypass the challenge to create molecular mechanosensitivity and use biological systems instead to sense membrane tension. With planarizable push–pull probes, this challenge is met not with twistome screening, but with “fluorescent flippers,” a new concept to insert large and bright monomers into oligomeric probes to really feel the environment and also shine when twisted out of conjugation.