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Punlop Kuntiyong Duangkamon Namborisut Kunita Phakdeeyothin Rungrawin Chatpreecha Kittisak Thammapichai 《Molecules (Basel, Switzerland)》2021,26(19)
Benzoquinolizidinone systems were synthesized in both enantiomeric forms from L-glutamic acid. The key chiral arylethylglutarimide intermediate was synthesized from dibenzylamino-glutamate and homoveratrylamine. Aldol reaction of the glutarimide afforded a mixture of syn and anti-aldol adducts. Subsequent regioselective hydride reduction of the glutarimide carbonyl followed by N-acyliminium ion cyclization afforded a product with opposite absolute configurations at C3 and C11b. Cope elimination of the dibenzylamino group then converted the two diastereomers into enantiomers. 相似文献
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