Comparison of structure,log<Emphasis Type="Italic">P</Emphasis> and P388 cytotoxicity of some phenyl and ferrocenyl cyclic chalcone analogues. Application of RP-TLC for log<Emphasis Type="Italic">P</Emphasis> determination of the ferrocenyl analogues

Cyclic chalcone analogues (2–5) and their ferrocenyl counterparts (6–10) were synthesized and their logP and P388 cyctotoxity were investigated. The structures of the newly synthesized compounds were confirmed by IR ¹H and ¹³NMR spectroscopy. Comparison of conjugation and stereochemistry of the respective derivatives showed similar characteristics compared to ones with some higher degree of conjugation in the ferrocenyl series. Comparison of logP of the ferrocenyl derivatives determined by a validated RP-TLC method showed the ferrocenyl derivatives to have higher logP _TLC. The results demonstrate that the differences in three dimensional shape, conjugation and lipophilicity do not have strong influence on the P388 cytotoxicity of the investigated phenyl (1−5) and ferrocenyl (6−10) enones.      

(E)-2-Benzylidenebenzocyclanones: Part X. Determination of log P of (E)-3-benzylidene-2,3-dihydro-1-benzopyran-4-ones by RP-TLC. Effect on log P of Incorporation of Oxygen Atom into Carbocyclic Chalcone Analogues

JPC – Journal of Planar Chromatography – Modern TLC - log P values of 14 biologically active (E)-3-(X-benzylidene)-2,3-dihydro-1-benzopyran-4-ones (3) have been determined by an...