Arzneimittel und pharmazeutische Pr?parate

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Nachweis von Gallenfarbstoff im Harn

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Ueber das Indigroth des Harns

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Photodynamic Therapy Mediated by 5‐aminolevulinic Acid Promotes the Upregulation and Modifies the Intracellular Expression of Surveillance Proteins in Oral Squamous Cell Carcinoma

Expression of proteins related to cell surveillance has been described in tumors presenting resistance to photodynamic therapy (PDT). The aim of this study was to verify whether there was upregulation of proteins related to resistance in oral squamous cell carcinoma (OSCC) after PDT. OSCC was chemically induced in rats and treated after one cycle of PDT mediated by 5‐aminolevulinic acid (5‐ALA‐PDT). Immunolabeling of p‐NFκB, Bcl‐2, survivin, iNOS, p‐Akt, p‐mTOR and cyclin D1 was performed after the treatment. There was increased expression of Bcl‐2 (P = 0.008), iNOS (P = 0.020), p‐Akt (P = 0.020) and p‐mTOR (P = 0.010) by surviving neoplastic cells after PDT when compared to the control. In conclusion, after one cycle of 5‐ALA‐mediated PDT, Bcl‐2, p‐Akt, p‐mTOR and iNOS were upregulated in neoplastic cells of OSCC, suggesting an activation of antiapoptosis and cell proliferation pathways. This fact must be considered in the establishment of PDT protocols for OSCC treatment, mainly those in which PDT will be combined with chemotherapy drugs targeted at the studied proteins.     

Nonlinear growth of firehose and mirror fluctuations in astrophysical plasmas

In turbulent high-beta astrophysical plasmas (exemplified by the galaxy cluster plasmas), pressure-anisotropy-driven firehose and mirror fluctuations grow nonlinearly to large amplitudes, deltaB/B approximately 1, on a time scale comparable to the turnover time of the turbulent motions. The principle of their nonlinear evolution is to generate secularly growing small-scale magnetic fluctuations that on average cancel the temporal change in the large-scale magnetic field responsible for the pressure anisotropies. The presence of small-scale magnetic fluctuations may dramatically affect the transport properties and, thereby, the large-scale dynamics of the high-beta astrophysical plasmas.     

Interassociates of the Free Commutative Semigroup on n Generators

The interassociates of the free commutative semigroup on n generators, for n > 1, are identified. For fixed n, let (S, ·) denote this semigroup. We show that every interassociate can be written in the form , depending only on a n-tuple . Next, if and are isomorphic interassociates of (S, ·) such that , for x_ii and x_j in the generating set of S, then . Moreover, if and only if is a permutation of .     

Die Präparation von GaAs-Substraten,untersucht mit Reflexionselektroneninterferenzen

The RHEED-method is used for the examination and characterization of gallium arsenide substrates. It is shown the use of both beam focussing at the object and at the photoplate in studying this subject. It was found that the samples after abrasive cutting and machine lapping give interference patterns of mechanical damaged surfaces with characteristical features. Lap polished surfaces give Kikuchi pattern and a rel-rod pattern of perfect single crystal which is nearly smooth in the atomic level. Critical remarks are given on the Kikuchi pattern as a feature of perfection of the crystal. Results on the penetration depth of rough defects due to machine lapping are in good agreement with data from literature.     

Brenn- und Kraftstoffe

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