排序方式: 共有2条查询结果,搜索用时 0 毫秒
1
1.
Michael D. Varney William H. Romines Theodore Boritzki Stephen A. Margosiak Charlotte Bartlett Eleanor J. Howland 《Journal of heterocyclic chemistry》1995,32(5):1493-1498
The synthesis and biological evaluation of N-[4-(2-trans-[([2,6-diamino-4(3H)-oxopyrimidin-5-yl]methyl)thio]cyclobutyl)benzoyl]-L-glutamic acid (1) is reported. Compound 1 is a potent dihydrofolate reductase (DHFR) inhibitor (Kj = 12 nM) with excellent in vitro cell culture growth inhibition (L1210, IC50 = 29 nM). Protection experiments showed that the cell growth inhibitory activity was due to DHFR inhibition. The key step in the synthesis was the coupling of a cyclobutylmethylthiol with the 5-bromo-2,6-diamino-4-oxopyrimidine 8. 相似文献
2.
Ehinger S. C. Pacer R. A. Romines F. L. 《Journal of Radioanalytical and Nuclear Chemistry》1986,98(1):39-48
A method for the separation of210Pb,210Bi and210Po using spontaneous deposition has been developed. The210Bi and210Po are simultaneously removed by deposition onto nickel foil (copper and tin could also be used but less effectively) while the210Po is separated from210Bi, after dissolution of the nickel foil, by deposition onto silver foil. The effectiveness of each separation was evaluated by adding aliquot portions of each solution to a cocktail and counting with a liquid scintillation counter. Water was used as the medium to observe the Cherenkov count of the sample solution. 相似文献
1