全文获取类型
收费全文 | 5086篇 |
免费 | 218篇 |
国内免费 | 38篇 |
专业分类
化学 | 3600篇 |
晶体学 | 19篇 |
力学 | 134篇 |
数学 | 736篇 |
物理学 | 853篇 |
出版年
2023年 | 46篇 |
2022年 | 91篇 |
2021年 | 149篇 |
2020年 | 137篇 |
2019年 | 131篇 |
2018年 | 86篇 |
2017年 | 81篇 |
2016年 | 199篇 |
2015年 | 139篇 |
2014年 | 176篇 |
2013年 | 311篇 |
2012年 | 351篇 |
2011年 | 439篇 |
2010年 | 251篇 |
2009年 | 239篇 |
2008年 | 363篇 |
2007年 | 345篇 |
2006年 | 288篇 |
2005年 | 291篇 |
2004年 | 225篇 |
2003年 | 161篇 |
2002年 | 170篇 |
2001年 | 64篇 |
2000年 | 45篇 |
1999年 | 35篇 |
1998年 | 32篇 |
1997年 | 33篇 |
1996年 | 41篇 |
1995年 | 34篇 |
1994年 | 30篇 |
1993年 | 27篇 |
1992年 | 32篇 |
1991年 | 22篇 |
1990年 | 32篇 |
1989年 | 17篇 |
1988年 | 27篇 |
1987年 | 20篇 |
1986年 | 15篇 |
1985年 | 23篇 |
1984年 | 15篇 |
1982年 | 18篇 |
1981年 | 15篇 |
1980年 | 12篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 8篇 |
1973年 | 7篇 |
排序方式: 共有5342条查询结果,搜索用时 250 毫秒
1.
Biodistribution study of free and microencapsulated 6‐methylcoumarin in Wistar rats by HPLC
下载免费PDF全文
![点击此处可从《Biomedical chromatography : BMC》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Aura Rocío Hernández Luis Fernando Ospina Diana Marcela Aragón 《Biomedical chromatography : BMC》2015,29(2):176-181
A sensitive, specific and reproducible HPLC method has been developed and validated for the quantitative determination of 6‐methylcoumarin (6MC) in plasma and other tissues in Wistar rats. A C18 column was used with UV detection at 321 nm and a gradient system consisting of methanol‐deionized water was used as mobile phase. The retention time for 6MC was 14.921 min and no interfering peaks were observed for any of the matrices. Linear relationships (r2 > 0.997) were obtained between the peak height ratios and the corresponding biological sample concentrations over the range 0.4–12.8 µg/mL. Precision and accuracy were evaluated; the coefficient of variation and the relative error for all of the organs were <2 and 7%, respectively. The limit of quantitation was 0.20 µg/mL for the heart and 0.30 µg/mL for the other tissues evaluated. This HPLC method was successfully used in the determination of 6MC in the biodistribution study after administration of 200 mg/kg of both 6MC‐free and 6MC‐loaded polymeric microparticles. In this study, extensive 6MC was found, in both free and microencapsulated forms, in all the organs tested. The 6MC‐free showed a range of between 1.7 and 11.5 µg/g, while the microencapsulated 6MC showed concentrations of between 6.35 and 17.7 µg/g, suggesting that 6MC improved absorption rate. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
2.
Guizellini Filipe Corrêa Franzin Bruno Trevizan da Silva Matheus Antonio Abra Luciana Mazotti Hojo Ossamu Pastre Iêda Aparecida Ribeiro Clóvis Augusto Paiva-Santos Carlos de Oliveira Fertonani Fernando Luis 《Journal of Thermal Analysis and Calorimetry》2021,143(1):47-60
Journal of Thermal Analysis and Calorimetry - The aim of this work is to synthesize and characterize a new structured silver–clay dried, calcined or sintered at different temperatures... 相似文献
3.
4.
Fernando Bento Cunha Karina Torres Pomini Ana Maria de Guzzi Plepis Virgínia da Conceio Amaro Martins Eduardo Gomes Machado Renato de Moraes Marcelo de Azevedo e Souza Munhoz Michela Vanessa Ribeiro Machado Marco Antonio Hungaro Duarte Murilo Priori Alcalde Daniela Vieira Buchaim Rogrio Leone Buchaim Victor Augusto Ramos Fernandes Eliana de Souza Bastos Mazuqueli Pereira Andr Antonio Pelegrine Marcelo Rodrigues da Cunha 《Molecules (Basel, Switzerland)》2021,26(6)
Autologous bone grafts, used mainly in extensive bone loss, are considered the gold standard treatment in regenerative medicine, but still have limitations mainly in relation to the amount of bone available, donor area, morbidity and creation of additional surgical area. This fact encourages tissue engineering in relation to the need to develop new biomaterials, from sources other than the individual himself. Therefore, the present study aimed to investigate the effects of an elastin and collagen matrix on the bone repair process in critical size defects in rat calvaria. The animals (Wistar rats, n = 30) were submitted to a surgical procedure to create the bone defect and were divided into three groups: Control Group (CG, n = 10), defects filled with blood clot; E24/37 Group (E24/37, n = 10), defects filled with bovine elastin matrix hydrolyzed for 24 h at 37 °C and C24/25 Group (C24/25, n = 10), defects filled with porcine collagen matrix hydrolyzed for 24 h at 25 °C. Macroscopic and radiographic analyses demonstrated the absence of inflammatory signs and infection. Microtomographical 2D and 3D images showed centripetal bone growth and restricted margins of the bone defect. Histologically, the images confirmed the pattern of bone deposition at the margins of the remaining bone and without complete closure by bone tissue. In the morphometric analysis, the groups E24/37 and C24/25 (13.68 ± 1.44; 53.20 ± 4.47, respectively) showed statistically significant differences in relation to the CG (5.86 ± 2.87). It was concluded that the matrices used as scaffolds are biocompatible and increase the formation of new bone in a critical size defect, with greater formation in the polymer derived from the intestinal serous layer of porcine origin (C24/25). 相似文献
5.
Mejía Hugo Fernando Giraldo Jiménez-Piqué Emilio Valdés Matías Procaccini Raúl Pellice Sergio 《Journal of Solid State Electrochemistry》2020,24(10):2451-2460
Journal of Solid State Electrochemistry - A novel material was developed using sol-gel chemistry and an environmental-friendly grafting process of clay nanoparticles. In a previous work of our... 相似文献
6.
An ultrasonic Doppler velocimeter (UDV) is used for an experimental investigation of turbulent pipe flow at eight different Reynolds numbers (22,300–854,900). The UDV is a multipoint probe in the sense that it takes instantaneous measurements of fluid velocities at different locations simultaneously, with remarkable resolutions in space and time. The performances of the instrument with respect to the properties of the overlap layer of the turbulent flow field are investigated; the experimental results are compared with both already existing and more recently proposed scaling laws, and with other data of experimental nature. 相似文献
7.
Rodrigo París José Luis de la Fuente 《Journal of polymer science. Part A, Polymer chemistry》2007,45(16):3538-3549
Different diblock copolymers constituted by one segment of a monomer supporting a reactive functional group, like allyl methacrylate (AMA), were synthesized by atom transfer radical polymerization (ATRP). Bromo‐terminated polymers, like polystyrene (PS), poly(methyl methacrylate) (PMMA), and poly(butyl acrylate) (PBA) were employed as macroinitiators to form the other blocks. Copolymerizations were carried out using copper chloride with N,N,N′,N″,N″‐pentamethyldiethylenetriamine (PMDETA) as the catalyst system in benzonitrile solution at 70 °C. At the early stage, the ATRP copolymerizations yielded well‐defined linear block copolymers. However, with the polymerization progress a change in the macromolecular architecture takes place due to the secondary reactions caused by the allylic groups, passing to a branched and/or star‐shaped structure until finally yielding gel at monomer conversion around 40% or higher. The block copolymers were characterized by means of size exclusion chromatography (SEC), 1H NMR spectroscopy, and differential scanning calorimetry (DSC). In addition, one of these copolymers, specifically P(BA‐b‐AMA), was satisfactorily modified through osmylation reaction to obtain the subsequent amphiphilic diblock copolymer of P(BA‐b‐DHPMA), where DHPMA is 2,3‐dihydroxypropyl methacrylate; demonstrating the feasibility of side‐chain modification of the functional obtained copolymers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 3538–3549, 2007 相似文献
8.
Humberto César Chaves Fernandes Arthur Rodrigo Barros da Rocha 《International Journal of Infrared and Millimeter Waves》2003,24(7):1171-1176
The use of photonic materials has been used in the theory of optical waves. The PBG (Photonic Band Gap) theory and material, was developed recently for optical frequencies and can be easily applied to millimeter waves, microwaves and planar antenna frequencies. The presence of photonic materials as substrate in antennas has some good characteristics such as, supression of light spontaneous emission and suppression of surface waves, allowing the application in planar antenna array. In this work an elaborate analysis using the full wave Transverse Transmission Line - TTL method, that provides efficient and concise results is applied to the planar antennas array with PBG substrate. 相似文献
9.
This work presents a formulation based on UPML for truncating conductive media by using a local and non-orthogonal coordinate
system to solve Maxwell’s equations by the FDTD method. The detailed procedure for obtaining the UPML equations for this case
is shown and the complete equation set is provided. 相似文献
10.
We study a boundary version of the gauged WZW model with a Poisson–Lie group G as the target. The Poisson–Lie structure of G is used to define the Wess–Zumino term of the action on surfaces with boundary. We clarify the relation of the model to the topological Poisson sigma model with the dual Poisson–Lie group G
* as the target and show that the phase space of the theory on a strip is essentially the Heisenberg double of G introduced by Semenov–Tian–Shansky. 相似文献