A comprehensive calorimetric,spectroscopic, and molecular docking investigation to probe the interaction of colchicine with HEWL

Journal of Thermal Analysis and Calorimetry - Colchicine (Col), a naturally occurring alkaloid, has been used as an anti-inflammatory, anti-fibrotic, and anti-tumor drug. The present study reports...     

Applicability of the Bertrand, Acree, and Burchfield Method of Predicting the Relative Permittivity of Ternary Mixtures

The Bertrand, Acree, and Burchfield (BAB) method has been employed to predict the relative permittivity of the ternary system: N,N-dimethylformamide-2-methoxyethanol-1,2-dimethoxyethane at seven temperatures from –10 to +20°C using reported relative permittivities for the three constituents' binary systems: N,N-dimethylformamide-2-methoxyethanol, 2-methoxyethanol-1, 2-dimethoxyethane, N,N-dimethylformamide-l, 2-dimethoxyethane. The agreement between the predicted and the experimental values is 99 ± 1%.     

Interactions in L-phenylalanine/L-leucine/L-glutamic Acid/L-proline + 2 M aqueous NaCl/2 M NaNO3 systems at different temperatures

Density (ρ) and speed of sound (u) in 2 M aqueous NaCl and 2 M NaNO₃ solutions of amino acids: L-phenylalanine, L-leucine, L-glutamic acid, and L-proline have been measured for several molal concentrations of amino acids at different temperatures. The ρ and u data have been used to calculate the values of isothermal compressibility and internal pressure at different temperatures. The trends of variations of κ _T and P _i with an increase in molal concentration of amino acid and temperature have been discussed in terms of solute-solvent and solute-solute interactions in the systems.     

Effects of concentration and temperature on molar volumes of L-serine, L-isoleucine, and L-glutamine in aqueous NaCl and NaNO3 solutions

Densities of L-serine, L-isoleucine, L-glutamine in 1.5 mol kg^?1 aqueous NaCl, and NaNO₃ solutions have been measured for several molal concentrations of amino acids at temperatures from 298.15 to 323.15 K. The partial molar volumes (? _v ⁰ ) of L-serine, L-isoleucine, and L-glutamine in 1.5 mol kg^?1 aqueous NaCl/NaNO₃ solutions have been computed using density data. The transfer partial molar volumes (Δ_tr? _v ⁰ ) of L-serine, L-isoleucine, and L-glutamine from water to 1.5 mol kg^?1 aqueous NaCl/1.5 mol kg^?1 aqueous NaNO₃ solutions have been determined at 298.15 K. The trends of variation of ? _v ⁰ and Δ_tr? _v ⁰ with change in temperature have been discussed in terms of ion-ion, ion-hydrophilic, and ion-hydrophobic interactions operative in solutions.