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1.
Determination of cefodizime in biological materials by high-performance liquid chromatography 总被引:1,自引:0,他引:1
Cefodizime (THR-221) is a new semi-synthetic cephalosporin. A high-performance liquid chromatographic method has been developed for the determination of cefodizime in biological materials. A plasma or serum sample was deproteinized with methanol and the resulting methanol eluate was concentrated to a volume of 0.5 ml. Urine and bile samples were diluted with buffer and each diluted sample was filtered. Faeces samples were homogenized and the supernate obtained after centrifugation was filtered. Visceral tissue samples were homogenized, the centrifuged supernate was deproteinized with methanol, and the methanol eluate was concentrated to a volume of 0.5 ml. Aliquots of each preparation were chromatographed on a reversed-phase column with an ion-pair chromatographic technique on a high-performance liquid chromatograph equipped with an UV detector set at 264 nm. The detection limits for cefodizime were 0.1 microgram/ml in plasma or serum, 0.3 microgram/ml in bile, and 0.5 microgram/ml in urine, 0.5 microgram/g in faeces and visceral tissue. This precise and sensitive assay for the determination of cefodizime is described, and its stability in several media is reported. 相似文献
2.
Morita Kentato Motoyama Keiichi Kuramoto Ayako Onodera Risako Higashi Taishi 《Journal of inclusion phenomena and macrocyclic chemistry》2021,100(3-4):169-175
Journal of Inclusion Phenomena and Macrocyclic Chemistry - In recent years, functional materials using cyclodextrin (CD)-based polyrotaxanes have attracted considerable attention, and... 相似文献
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Teruyoshi Marunaka 《Journal of heterocyclic chemistry》1981,18(5):1041-1045
The electron impact mass spectra of 1-sulfonyl substituted derivatives of 5-fluorouracil were investigated. The substituents were CH3SO2 (compound I), CH3(CH2)3SO2 (II), C6H5SO2 (III) and p-CH3C6H4SO2 (IV). 相似文献
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Onodera Risako Sakai Aiko Tokuda Azumi Higashi Taishi Motoyama Keiichi 《Journal of inclusion phenomena and macrocyclic chemistry》2022,102(1-2):143-149
Journal of Inclusion Phenomena and Macrocyclic Chemistry - Among gynaecological cancers, ovarian cancer is known to be highly sensitive to chemotherapy. However, it is often detected at an advanced... 相似文献
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Risako Onodera Keiichi Motoyama Hidetoshi Arima 《Journal of inclusion phenomena and macrocyclic chemistry》2011,70(3-4):321-326
Methyl-??-cyclodextrin (M-??-CyD) is widely used as a raft disrupting agent through extraction of cholesterol from lipid rafts which are highly expressed in cell membranes of tumor cells, but it does not have tumor cell-selective action. Meanwhile, the widespread use of folic acid (FA) as a tumor-targeting ligand has been known, because folate receptor (FR) overexpresses in various kinds of epithelial tumor cells. In the present study, in order to obtain more tumor cell-selectivity and antitumor activity of M-??-CyD, we designed folate-appended M-??-CyD (FA-M-??-CyD), and evaluated its physicochemical properties and antitumor activity. The 1H-NMR study demonstrated that FA-M-??-CyD having average degree of substitution of FA (DSF) of 1.0 was prepared. In addition, FA-M-??-CyD (DSF 1.0) was found to be amorphous in a solid state and surface-active. Importantly, FA-M-??-CyD (DSF 1.0) had potent cytotoxicity, compared to M-??-CyD in KB cells, but not in A549 cells. These results suggest that FA-M-??-CyD (DSF 1.0) has the potential as a novel antitumor agent. 相似文献
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J Nishigaki R Tsunoyama H Tsunoyama N Ichikuni S Yamazoe Y Negishi M Ito T Matsuo K Tamao T Tsukuda 《Journal of the American Chemical Society》2012,134(35):14295-14297
A gold cluster, Au(41)(S-Eind)(12), was synthesized by ligating the bulky arenethiol 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacene-4-thiol (Eind-SH) to preformed Au clusters. Extended X-ray absorption fine structure, X-ray photoelectron spectroscopy, and the fragmentation pattern in the mass spectrometry analysis indicated that formation of gold-thiolate oligomers at the interface was suppressed, in sharp contrast to conventional thiolate-protected Au clusters. 相似文献
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The 8-fluoro-4-methyl-1-naphthol forms the intermolecular bifurcated HB, OH?(F, HO) in the crystal. This is quite contrasting to the reported results of the ab initio calculations. On the contrary, the intramolecular hydrogen bond in solution was confirmed by 1H, 13C, and 19F NMR spectra. 相似文献
9.
Tomoko Ishikawa Akino Kawamura Tsuyoshi Sugawa Risako Moridaira Koji Yamamoto Tetsuro Murahashi 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(43):15462-15467
The ligand‐unsupported accommodation of extra metal moieties in a sandwich complex is reported. Although it has been considered that the metal‐capacity of a metal sheet sandwich complex is strictly limited by the size of cyclic unsaturated hydrocarbon ligands, the M?M edge bonds in a metal sheet sandwich complex provide a ligand‐unsupported docking site for extra metal moieties, allowing expansion of metal‐capacity in sandwich complexes. The metal sheet sandwich complex [Pd4(μ4‐C8H8)(μ4‐C9H9)]+, in which the ligand‐based metal capacity is full in terms of the usage of all C=C moieties of the smaller carbocyclic ligand C8H8 in coordination, can accommodate extra M0{P(OPh)3}2 (M=Pd, Pt) moieties without coordinative assistance by either the C9H9 or the C8H8 ligand. 相似文献
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