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Summary A review is made of the existing theoretical expressions, describing the change of the scattered light intensity and the birefringence by application of an electrical field to a colloid solution.Furthermore, the geometrical functions for disc-shaped particles are calculated in this article for the case of electric light scattering and are. presented graphically. In addition, expressions are derived for the average value of the electrical polarizability () for the case of polydisperse solutions.
With 1 figure and 1 table 相似文献
Zusammenfassung Es wird ein überblick über die existierenden theoretischen Beziehungen gegeben, die die Änderung der Intensität des Streulichtes und der Doppelbrechung von Kolloidsuspensionen im elektrischen Feld beschreiben.Weiterhin sind die geometrischen Funktionen für scheibchenförmige Teilchen in dieser Arbeit für den Fall der elektrooptischen Lichtstreuung berechnet und grafisch dargestellt. Außerdem werden Beziehungen für den Mittelwert der elektrischen Polarisierbarkeit () für den Fall polydisperser Suspensionen abgeleitet.
With 1 figure and 1 table 相似文献
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Kizek R Masarik M Kramer KJ Potesil D Bailey M Howard JA Klejdus B Mikelova R Adam V Trnkova L Jelen F 《Analytical and bioanalytical chemistry》2005,381(6):1167-1178
The electroanalytical determination of avidin in solution, in a carbon paste, and in a transgenic maize extract was performed in acidic medium at a carbon paste electrode (CPE). The oxidative voltammetric signal resulting from the presence of tyrosine and tryptophan in avidin was observed using square-wave voltammetry. The process could be used to determine avidin concentrations up to 3 fM (100 amol in 3 l drop) in solution, 700 fM (174 fmol in 250 l solution) in an avidin-modified electrode, and 174 nM in a maize seed extract. In the case of the avidin-modified CPE, several parameters were studied in order to optimize the measurements, such as electrode accumulation time, composition of the avidin-modified CPE, and the elution time of avidin. In addition, the avidin-modified electrode was used to detect biotin in solution (the detection limit was 7.6 pmol in a 6 l drop) and to detect biotin in a pharmaceutical drug after various solvent extraction procedures. Comparable studies for the detection of biotin were developed using HPLC with diode array detection (HPLC-DAD) and flow injection analysis with electrochemical detection, which allowed biotin to be detected at levels as low as 614 pM and 6.6 nM, respectively. The effects of applied potential, acetonitrile content, and flow rate of the mobile phase on the FIA-ED signal were also studied. 相似文献
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Dr. Tana Koudelakova Dr. Radka Chaloupkova Dr. Jan Brezovsky Dr. Zbynek Prokop Dr. Eva Sebestova Dr. Martin Hesseler Dr. Morteza Khabiri Maryia Plevaka Daryna Kulik Dr. Ivana Kuta Smatanova Dr. Pavlina Rezacova Dr. Rudiger Ettrich Prof. Uwe T. Bornscheuer Prof. Jiri Damborsky 《Angewandte Chemie (International ed. in English)》2013,52(7):1959-1963
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Radka Novotn Zdenk Trvní
ek 《Acta Crystallographica. Section C, Structural Chemistry》2013,69(2):158-161
The asymmetric unit of the title compound, C6H5N3O, consists of discrete molecules of 9‐deazahypoxanthine [systematic name: 3H‐pyrrolo[3,2‐d]pyrimidin‐4(5H)‐one]. The structure displays N—H...O hydrogen bonding, connecting the molecules into centrosymmetric dimers. These dimers are then connected by N—H...N hydrogen bonds into a ladder‐like chain along the c axis. The secondary structure is stabilized by weak noncovalent contacts of the C—H...O and C—H...C types, as well as by π–π stacking interactions, which organize the structure into a zigzag architecture. 相似文献
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Petr Tůma Martin Jaček Blanka Sommerová Pavel Dlouhý Radka Jarošíková Jitka Husáková Veronika Wosková Vladimíra Fejfarová 《Electrophoresis》2022,43(11):1129-1139
Determination of the broad-spectrum antibiotics amoxicilline (AMX) and ceftazidime (CTZ) in blood serum and microdialysates of the subcutaneous tissue of the lower limbs is performed using CE with contactless conductivity detection (C4D). Baseline separation of AMX is achieved in 0.5 M acetic acid as the background electrolyte and separation of CTZ in 3.2 M acetic acid with addition of 13% v/v methanol. The CE-C4D determination is performed in a 25 µm capillary with suppression of the EOF using INST-coating on an effective length of 18 cm and the attained migration time is 4.2 min for AMX and 4.4 min for CTZ. The analysis was performed using 20 µl of serum and 15 µl of microdialysate, treated by the addition of acetonitrile in a ratio of 1/3 v/v and the sample is injected into the capillary using the large volume sample stacking technique. The LOQ attained in the microdialysate is 148 ng/ml for AMX and 339 ng/ml for CTZ, and in serum 143 ng/ml for AMX and 318 ng/ml for CTZ. The CE-C4D method is employed for monitoring the passage of AMX and CTZ from the blood circulatory system into the subcutaneous tissue at the sites of diabetic ulceration in patients suffering from diabetic foot syndrome and also for measuring the pharmacokinetics following intravenous application of bolus antibiotic doses. 相似文献
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Structure‐Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry 下载免费PDF全文
Milon Mondal Nedyalka Radeva Dr. Helene Köster Dr. Ahyoung Park Dr. Constantinos Potamitis Dr. Maria Zervou Prof. Dr. Gerhard Klebe Dr. Anna K. H. Hirsch 《Angewandte Chemie (International ed. in English)》2014,53(12):3259-3263
Structure‐based design (SBD) can be used for the design and/or optimization of new inhibitors for a biological target. Whereas de novo SBD is rarely used, most reports on SBD are dealing with the optimization of an initial hit. Dynamic combinatorial chemistry (DCC) has emerged as a powerful strategy to identify bioactive ligands given that it enables the target to direct the synthesis of its strongest binder. We have designed a library of potential inhibitors (acylhydrazones) generated from five aldehydes and five hydrazides and used DCC to identify the best binder(s). After addition of the aspartic protease endothiapepsin, we characterized the protein‐bound library member(s) by saturation‐transfer difference NMR spectroscopy. Cocrystallization experiments validated the predicted binding mode of the two most potent inhibitors, thus demonstrating that the combination of de novo SBD and DCC constitutes an efficient starting point for hit identification and optimization. 相似文献